Patents by Inventor Sándor Sólyom
Sándor Sólyom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20080269202Abstract: Disclosed are novel 2,3-benzodiazepine derivatives and methods of making the same.Type: ApplicationFiled: April 2, 2008Publication date: October 30, 2008Applicant: Teva Pharmaceutical Industries Ltd.Inventors: Emese Csuzdi, Sandor Solyom, Pal Berzsenyi, Ferenc Andrasi, Istvan Sziraki, Katalin Horvath, Zoltan Nagy
-
Publication number: 20070027143Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.Type: ApplicationFiled: February 3, 2004Publication date: February 1, 2007Inventors: Sandor Solyom, Gizella Abraham, Tamas Hamori, Pal Berzsenyl, Fenrec Andrasi, Istvan Kurucz
-
Patent number: 6858605Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.Type: GrantFiled: February 4, 2003Date of Patent: February 22, 2005Assignee: IVAX Drug Research Institute, Ltd.Inventors: Sándor Sólyom, Gizella Ábrahám, Tamás Hámori, Pál Berzsenyi, Ferenc Andrási, István Kurucz
-
Publication number: 20040152694Abstract: The present invention provides compositions and methods for treating inflammatory disorders of the airways by the administration of a therapeutically effective amount of a modulator according to the invention. More specifically, the invention relates to the treatment of airway inflammations including asthma or an asthma-related pathologies.Type: ApplicationFiled: February 4, 2003Publication date: August 5, 2004Inventors: Istvan Kurucz, Sandor Solyom, Viola Csillik nee Perczel
-
Publication number: 20040152693Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.Type: ApplicationFiled: February 4, 2003Publication date: August 5, 2004Inventors: Sandor Solyom, Gizella Abraham, Tamas Hamori, Pal Berzsenyi, Ferenc Andrasi, Istvan Kurucz
-
Patent number: 6600036Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.Type: GrantFiled: November 27, 2001Date of Patent: July 29, 2003Assignee: Schering AktiengesellschaftInventors: Ernese Csuzdi, Tamas Hamori, Gizella Abraham, Sandor Solyom, Istvan Tarnawa, Pal Berzsenyi, Ferenc Andrasi, Istvan Ling, Antal Simay, Melinda Gal, Katalin Horvath, Eszter Szentkuti, Marta Szollosy, Istvan Pallagi
-
Patent number: 6482819Abstract: 2,3-Benzodiazepines of formula (I), their stereoisomers and acid addition salts, wherein the variables have the meaning given in the specification, and pharmaceutical compositions containing them which are suitable for treating conditions associated with muscle spasms, epilepsy as well as acute and chronic forms of neurodegenerative diseases are disclosed.Type: GrantFiled: April 10, 2000Date of Patent: November 19, 2002Assignee: Gyogyszerkutato Intezet Kft.Inventors: Gizella Ábrahám, Emese Csuzdi, Sándor Sólyom, Pál Berzsenyi, István Tarnawa, Ferenc Andrási, István Ling, Tamás Hámori, Katalin Horváth, Imre Moravcsik, István Pallagi, Antal Simay
-
Publication number: 20020052364Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.Type: ApplicationFiled: November 27, 2001Publication date: May 2, 2002Inventors: Ernese Csuzdi, Tamas Hamori, Gizella Abraham, Sandor Solyom, Istvan Tarnawa, Pal Berzsenyl, Ferenc Andrasi, lstvan Ling, Antal Simay, Melinda Gal, Katalin Horvath, Eszter Szentkuti, Marta Szollosy, Istvan Pallagi
-
Patent number: 6323197Abstract: The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean —O—(CH2)n—O—; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member heterocycle which can contain between 1 and 3 nitrogen atoms and/or an oxygen atom and/or one or two carbonyl groups. Owing to their non-competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.Type: GrantFiled: November 5, 1998Date of Patent: November 27, 2001Assignee: Schering AktiengesellschaftInventors: Ernese Csuzdi, Tamas Hámori, Gizella Ábrahám, Sändor Sólyom, István Tarnawa, Pál Berzsenyi, Ferenc Andrási, István Ling, Antal Simay, Melinda Gál, Katalin Horváth, Eszter Szentkuti, Márta Szöllosy, István Pallagi
-
Patent number: 6200970Abstract: A compound of formula I in which X means hydrogen or halogen, Y means —NR3— or —N═, R1 and R2 are the same or different and mean hydrogen, C1-C6 alkyl, nitro, halogen, the group —NR8R9, —O—C1-4 alkyl, —CF3, OH or C1-6 alkanoyloxy, R3 means hydrogen, the group —CO—R10, C1-6 alkyl or C3-7 cycloalkyl, R4 means optionally substituted C1-C6 alkyl, R5 means hydrogen or R4 and R5 together mean oxygen, R6 means C1-4 alkyl, R8 and R9 are the same or different and mean hydrogen, C1-C6 alkyl or —CO—C1-6 alkyl, R10 means hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C6-10 aryl, the group —NR11R12, —O—C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or —O—C3-7 cycloalkyl, R11 and R12 are the same or different and mean hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C6-10 aryl and —C...C...Type: GrantFiled: November 5, 1998Date of Patent: March 13, 2001Assignee: Schering AktiengesellschaftInventors: István Ling, Gizella Ábrahám, Sándor Sólyom, Tamás Hámori, István Tarnawa, Pál Berzsenyi, Ferenc Andrási, Emese Csuzdi, Márta Szöllósy, Antal Simay, István Lagi, Katalin Horváth
-
Patent number: 5807851Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.Type: GrantFiled: April 4, 1997Date of Patent: September 15, 1998Assignee: Egis Gyogyszergyar Rt.Inventors: Istvan Ling, Gizella Abraham, Pal Berzsenyi, Istvan Tarnawa, Sandor Solyom, Ferenc Andrasi, Tamas Hamori, Emese Csuzdi, Katalin Horvath, Melinda Gal, Imre Moravcsik, Marta Szollosy
-
Patent number: 5756495Abstract: New 3-substituted 3H-2,3-benzodiazepine derivatives of general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and n have the meanings indicated in the description, their production as well as their use as pharmaceutical agents are described.Type: GrantFiled: January 31, 1997Date of Patent: May 26, 1998Assignee: Schering AktiengesellschaftInventors: Tamas Hamori, Istvan Tarnawa, Sandor Solyom, Pal Berzsenyi, Erzsebet Birkas, Ferenc Andrasi, Istvan Ling, Tibor Hasko, Gabor Kapus, Emese Csuzdl, Marta Szollosy, Franciska Erdo, Antal Simay, Gabor Zolyomi
-
Patent number: 4668437Abstract: The invention relates to new pregnene derivatives of the general formula (I), ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;R.sup.2 stands for a hydrogen atom or a C.sub.2-4 alkanoyl group;R.sup.3 stands for a hydrogen atom, a hydroxyl group or a C.sub.2-4 alkanoyloxy group;A represents a ring of the general formula (1) ##STR2## or a ring of the general formula (2), ##STR3## wherein R.sup.4 means a hydrogen atom or a methyl group;R.sup.5 stands for a hydroxyl group, a C.sub.2-4 alkanoyloxy group or a C.sub.1-3 alkoxy group;R.sup.6 means a hydroxyl group, a C.sub.2-4 alkanoyloxy group, a C.sub.1-3 alkoxy group, an oxo group or a C.sub.2-3 alkylenedithio group;the dotted line optionally represents one or more additional valence bonds, with the proviso that, when the dotted line between C.sub.9 and C.sub.11 represents an additional valence bond, then R.sup.Type: GrantFiled: September 11, 1985Date of Patent: May 26, 1987Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Sandor Solyom, Lajos Toldy, Katalin Szilagyi nee Farago
-
Patent number: 4342754Abstract: New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed.The new compounds have antimineral corticoide effects and have the following formula (I), ##STR1## wherein R.sub.1 is a C.sub.1-3 alkyl or a C.sub.2-4 alkenyl group, andZ is a group of the formulae (II) to (VI), ##STR2## wherein R.sub.2 is methyl or ethyl,R.sub.3 is hydrogen or methylR.sub.4 is hydrogen, a C.sub.1-3 alkyl group, a di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl group, a C.sub.2-4 alkylcarbonyl group, a C.sub.2-4 alkoxycarbonyl group or a C.sub.3-6 carboxyalkylcarbonyl group, andthe dotted lines may represent additional valence bonds, with the proviso that if Z is a group of the formula (VI), a double bond exists between the carbon atoms in positions 4 and 5 or 5 and 6, andif R.sub.4 is a di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl group or a C.sub.3-6 carboxyalkylcarbonyl group, the compounds may also be formed as their salts.Type: GrantFiled: March 11, 1981Date of Patent: August 3, 1982Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Sandor Solyom, Katalin Szilagyi nee Farago, Lajos Toldi, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente
-
Patent number: 4328221Abstract: Compounds of the formula (I) having aldosterone-antagonizing activity are disclosed ##STR1## wherein R.sub.3 and R.sub.4 are each C.sub.1 to C.sub.3 alkyl; andZ is one of the following groups ##STR2## wherein R.sub.1 is hydrogen or methyl;R.sub.6 is hydrogen, C.sub.1 to C.sub.3 alkylthio or C.sub.2 to C.sub.4 acylthio; andX is oxo, hydroximino, C.sub.1 to C.sub.3 alkoxyimino, carboxy-alkoxyimino wherein the alkoxy has 2 to 4 carbon atoms or a salt-converted carboxy-alkoxy-imino wherein the alkoxy has 2 to 4 carbon atoms.Type: GrantFiled: December 24, 1980Date of Patent: May 4, 1982Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Katalin Szilagyi nee Farago, Sandor Solyom, Lajos Toldy, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente
-
Patent number: 4218446Abstract: Diuretic pharmaceutically active steroid-spiro-oxazolidinone compounds of the formula (I), ##STR1## wherein R.sup.1 is hydrogen or methyl,R.sup.2 is C.sub.1-4 alkyl,R.sup.3 is hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkenyl,Z.sup.1 and Z.sup.2 each are hydrogen or together form a second valence bond, or Z.sup.1 is hydrogen and Z.sup.2 is R.sup.4 --S--,Z.sup.3 and Z.sup.4 each are hydrogen or together form a second valence bond, or Z.sup.3 is hydrogen and Z.sup.4 is R.sup.4 --S--, with at least one of the pairs Z.sup.1 -Z.sup.2 and Z.sup.3 -Z.sup.4 representing hydrogen and an R.sup.4 --S-- group, andR.sup.4 is hydrogen or alkyl, alkenyl, aralkyl or acyl with up to 7 carbon atoms, provided that when Z.sup.1 and Z.sup.2 together form a valence bond, or Z.sup.1 represents a hydrogen atom and Z.sup.2 and R.sup.4 --S-- group then R.sup.1 is methyl.Type: GrantFiled: March 29, 1979Date of Patent: August 19, 1980Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Sandor Solyom, Lajos Toldy, Katalin Szilagyi nee Farago, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente