Patents by Inventor Sónia MELO

Sónia MELO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • miRNA biogenesis in exosomes for diagnosis and therapy
    Patent number: 11926824
    Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: March 12, 2024
    Assignees: Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Raghu Kalluri, Sónia Melo
  • Use of exosomes for the treatment of disease
    Patent number: 10959952
    Abstract: The present invention provides lipid-based nanoparticles (e.g., liposomes or exosomes) having CD47 on their surface and comprising a therapeutic agent (e.g., a therapeutic protein, an antibody, an inhibitory RNA, and/or a small molecule drug). Furthermore, the present invention provides for use of such lipid-based nanoparticles in therapy.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 30, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raghu Kalluri, Sónia Melo
  • miRNA BIOGENESIS IN EXOSOMES FOR DIAGNOSIS AND THERAPY
    Publication number: 20200255831
    Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
    Type: Application
    Filed: March 23, 2020
    Publication date: August 13, 2020
    Applicants: Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Raghu KALLURI, Sónia MELO
  • ANALYSIS OF GENOMIC DNA, RNA, AND PROTEINS IN EXOSOMES FOR DIAGNOSIS AND THERANOSIS
    Publication number: 20200200755
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Application
    Filed: March 4, 2020
    Publication date: June 25, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Raghu KALLURI, Sónia MELO
  • Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis
    Patent number: 10598665
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: March 24, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raghu Kalluri, Sónia Melo
  • USE OF EXOSOMES FOR THE TREATMENT OF DISEASE
    Publication number: 20190117570
    Abstract: The present invention provides lipid-based nanoparticles (e.g., liposomes or exosomes) having CD47 on their surface and comprising a therapeutic agent (e.g., a therapeutic protein, an antibody, an inhibitory RNA, and/or a small molecule drug). Furthermore, the present invention provides for use of such lipid-based nanoparticles in therapy.
    Type: Application
    Filed: November 28, 2018
    Publication date: April 25, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Raghu KALLURI, Sónia MELO
  • USE OF EXOSOMES FOR THE TREATMENT OF DISEASE
    Publication number: 20180177727
    Abstract: The present invention provides lipid-based nanoparticles (e.g., liposomes or exosomes) having CD47 on their surface and comprising a therapeutic agent (e.g., a therapeutic protein, an antibody, an inhibitory RNA, and/or a small molecule drug). Furthermore, the present invention provides for use of such lipid-based nanoparticles in therapy.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 28, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Raghu KALLURI, Sonia MELO
  • Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis
    Patent number: 9921223
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: March 20, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raghu Kalluri, Sónia Melo
  • ANALYSIS OF GENOMIC DNA, RNA, AND PROTEINS IN EXOSOMES FOR DIAGNOSIS AND THERANOSIS
    Publication number: 20180045728
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Application
    Filed: November 1, 2017
    Publication date: February 15, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Raghu KALLURI, Sónia MELO
  • ANALYSIS OF GENOMIC DNA, RNA, AND PROTEINS IN EXOSOMES FOR DIAGNOSIS AND THERANOSIS
    Publication number: 20170059572
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Application
    Filed: December 4, 2014
    Publication date: March 2, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Raghu KALLURI, Sónia MELO
  • miRNA BIOGENESIS IN EXOSOMES FOR DIAGNOSIS AND THERAPY
    Publication number: 20160024503
    Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicants: Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Raghu KALLURI, Sónia MELO