Patents by Inventor S. R. Fletcher

S. R. Fletcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzodiazepine derivatives
    Patent number: 5302591
    Abstract: Compounds of formula (I), and salts and prodrugs thereof ##STR1## R.sup.1 is H, certain optionally substituted alkyl or C.sub.3-7 cycloalkyl;R.sup.2 represents (CH.sub.2).sub.m -tetrazolyl, (CH.sub.2).sub.m -imidazolyl, CONR.sup.6 R.sup.7, CONHSO.sub.2 R.sup.9, SO.sub.2 NHCOR.sup.9, SOC.sub.1-4 alkyl, SO.sub.2 NHR.sup.10, 5-hydroxy-4-pyrone, (CH.sub.2).sub.n CO.sub.2 H, ##STR2## or a group ##STR3## wherein X is O, S or NR.sup.11 ; one of Z and Y is C.dbd.O and the other is O, S or NR.sup.12 ;R.sup.3 represents H or C.sub.1-6 alkyl;R.sup.4 represents 2-, 3- or 4-pyridyl;R.sup.5 represents C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; andx is 0, 1, 2 or 3;are CCK and/or gastrin receptor antagonists useful in therapy.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: April 12, 1994
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: S. R. Fletcher, V. G. Matassa