Patents by Inventor Søren Bregenholt Frederiksen

Søren Bregenholt Frederiksen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-Rhesus D Recombinant Polyclonal Antibody and Methods of Manufacture
    Publication number: 20120322690
    Abstract: The invention relates to a method for manufacturing an anti-RhD recombinant polyclonal antibody composition (anti-RhD rpAb). The method comprises obtaining a collection of cells transfected with a library of anti-RhD antibody expression vectors, wherein each cell in the collection is capable of expressing from a VH and VL comprising nucleic acid segment, one member of the library, which encodes a distinct member of anti-RhD recombinant polyclonal antibody composition and is located at the same site in the genome of individual cells in said collection. The cells are cultured under suitable conditions for expression of the recombinant polyclonal antibody, which is obtained from the cells or culture supernatant. Nucleic acid segments encoding the anti-RhD rpAb are introduced into the cells by transfection with a library of vectors for site-specific integration.
    Type: Application
    Filed: June 11, 2012
    Publication date: December 20, 2012
    Applicant: Symphogen A/S
    Inventors: Søren Kofoed RASMUSSEN, Anne Bondgaard Tolstrup, Søren Bregenholt Frederiksen, John Haurum
  • Anti-rhesus D recombinant polyclonal antibody
    Patent number: 8198415
    Abstract: The invention relates to a method for manufacturing an anti-RhD recombinant polyclonal antibody composition (anti-RhD rpAb). The method comprises obtaining a collection of cells transfected with a library of anti-RhD antibody expression vectors, wherein each cell in the collection is capable of expressing from a VH and VL comprising nucleic acid segment, one member of the library, which encodes a distinct member of anti-RhD recombinant polyclonal antibody composition and which is located at the same site in the genome of individual cells in said collection. The cells are cultured under suitable conditions for expression of the recombinant polyclonal antibody, which is obtained from the cells or culture supernatant. The nucleic acid segments encoding the anti-RhD rpAb is introduced into the cells by transfection with a library of vectors for site-specific integration.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: June 12, 2012
    Assignee: Symphogen A/S
    Inventors: Søren Kofoed Rasmussen, Anne Bondgaard Tolstrup, Søren Bregenholt Frederiksen, John Haurum