Abstract: Recent advances in the understanding of macrophage biology has revealed that tumor-associated macrophages are very heterogeneous and that several distinct subsets coexist in the tumor microenvironment. These subsets differ not only in terms of expression profile and origin but also in their pro- or anti-tumoral function. Here, the inventors describe a macrophage subset in mouse models of metastatic melanoma that express CD 163. Specific depletion of the CD 163 expressing cells in an anti-PD-1 checkpoint inhibitor resistant melanoma model using cytotoxic lipid nanoparticles conjugated to ?CD163 mAh results in a massive infiltration of CD4+ and activated CD8+ T-cells. Moreover the inventors show that tumors quickly relapsed with combined treatment with anti-PDI antibodies.

Abstract: A system and a method of sampling an event signal using multiple clocking signals each provided in a separate candidate clock domain each of which also receives points in time from a master clock. From each candidate clock domain, clocked by the individual clocking signals, pairs of a received point in time and event signal value are fed to a master clock domain. In the master clock domain, the values of the event signal may be determined over time as a function of master clock time. This may be used for synchronizing operation in the master clock domain of e.g. packet time stamping with an overall time defined by the event signal. Using multiple clocking signals for the sampling, a much more precise sampling of the event signal is facilitated.

Abstract: The present invention relates to agents comprising a binding moiety with binding specificity for SRCR domain 1 of the CD163 receptor, for use in medicine. The invention also relates to methods, uses, kits and compositions comprising such agents.

Abstract: A system and a method of sampling an event signal using multiple clocking signals each provided in a separate candidate clock domain each of which also receives points in time from a master clock. From each candidate clock domain, clocked by the individual clocking signals, pairs of a received point in time and event signal value are fed to a master clock domain. In the master clock domain, the values of the event signal may be determined over time as a function of master clock time. This may be used for synchronizing operation in the master clock domain of e.g. packet time stamping with an overall time defined by the event signal. Using multiple clocking signals for the sampling, a much more precise sampling of the event signal is facilitated.

Abstract: A method and apparatus adapted to prevent Head-Of-Line blocking by forwarding dummy packets to queues which have not received data for a predetermined period of time. This prevention of HOL may be on an input where data is forwarded to each of a number of FIFOs or an output where data is de-queued from FIFOs. The dummy packets may be provided with a time stamp derived from a recently queued or de-queued packet.

Abstract: The present invention relates to a medical injection device (1) for use in combination with a medicament filled cartridge (2), the injection device being provided with a spring-assisted injecting mechanism where energy released from the spring moves a plunger (3) of a held cartridge (2). Sensor circuitry is adapted to detect speed related data during injection so at to detect an abnormal speed condition, such as a needle blocking condition, a priming condition or an air purge condition. The invention also relates to a medical injection device comprising sensor circuitry and user communicating means to provide a recommended needle retraction waiting period which is dependent on the speed of injection.

Abstract: An apparatus and a method for receiving and forwarding packets, where the packets are received by a number of adapters and fed to a common storage in addresses allocated by a controller. The controller is adapted to forward to the adapters requests and at the same time log which addresses have been allocated to each adapter. As a response to the request, the individual adapter forwards predetermined data to predetermined addresses in the storage so that the controller is able to update the available or the used addresses in the storage.

Abstract: A method and apparatus adapted to prevent Head-Of-Line blocking by forwarding dummy packets to queues which have not received data for a predetermined period of time. This prevention of HOL may be on an input where data is forwarded to each of a number of FIFOs or an output where data is de-queued from FIFOs. The dummy packets may be provided with a time stamp derived from a recently queued or de-queued packet.

Abstract: The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent is a glucocorticoid-antibody conjugate. The invention also relates to methods, uses, kits and compositions comprising such agents.

Abstract: The present invention relates to agents comprising a binding moiety with binding specificity for SRCR domain 1 of the CD163 receptor, for use in medicine. The invention also relates to methods, uses, kits and compositions comprising such agents.

Abstract: The present invention relates to a medical injection device (1) for use in combination with a medicament filled cartridge (2), the injection device being provided with a spring-assisted injecting mechanism where energy released from the spring moves a plunger (3) of a held cartridge (2). Sensor circuitry is adapted to detect speed related data during injection so at to detect an abnormal speed condition, such as a needle blocking condition, a priming condition or an air purge condition. The invention also relates to a medical injection device comprising sensor circuitry and user communicating means to provide a recommended needle retraction waiting period which is dependent on the speed of injection.

Abstract: A system and method for program counter and data tracing in a multi-issue processor is disclosed. Instructions are traced in program sequence order. In one embodiment instructions are traced in graduation order from a reorder buffer. The tracing mechanism of the present invention enables increased visibility into the hardware and software state of the processor core.