Abstract: The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders.

Abstract: Disclosed is a method for determining the cellular or tissue origin of tumor cells. The method entails determining the presence of at least one micro RNA (miRNA) in a sample derived from tumor tissue and based on the said determination establishing a miRNA expression profile and comparing this with pre-established miRNA expression profiles from cells, tissues or tumors. The determination uses short oligonucleotide probes comprising modified affinity-enhancing nucleobases.

Abstract: The present invention relates to functional analysis of miRNAs or other short non-coding RNAs involving the use of two or more sequence distinct miRNAs antagonising oligomeric compounds, which enables the reagent redundancy experiments to reduce the risk of reporting false positive effects of miRNA/ncRNA antagonists.

Abstract: The invention concerns a rotation angle sensor, in particular a steering angle sensor (1) for a steering unit, with a housing (2) comprising an exterior (8), a transmitter (7) arranged in a sensor chamber in the housing (2) to perform rotary movements around a rotation axis, and a stationary receiver interacting with the pick-up sensor (7). It is endeavoured to make such steering angle sensors fit for rough environmental conditions. For this purpose, the sensor chamber is connected to the exterior (8) via at least one free space (16).

Abstract: The present invention relates to novel modified oligomeric compounds and to methods of making and using such compounds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compounds comprising conjugating a metal chelator to those.

Abstract: The invention provides a steering system comprising a controlled element which is movable in a neutral area comprising a neutral position and in areas on opposite sides of the neutral area based on a steering input and a handle for requesting a desired position for the controlled element. The handle is movable between set-points in a centre zone comprising a centre set-point and set-points on opposite sides of the centre zone. Furthermore, a steering unit is arranged to receive set-points from the handle, to determine a corresponding controlled position of the controlled element, and to move the controlled element to said controlled position. In order to prevent or reduce jerks, the steering unit is adapted to vary a speed by which the controlled element is moved to the controlled position. The speed is variable in dependence of the received set-point.

Abstract: The invention provides a method of calibrating a steering system for a vehicle, e.g. an off-highway machinery, to allow automatic steering based on input from a position or tracking system, e.g. based on a Global Positioning System (GPS). At least two records, each comprising a position value and a curvature value are established. The position value represents a position of the steered element, e.g. a position of a steered wheel of the vehicle, and the curvature value could e.g. be expressed as a radius of a curve followed by the vehicle with that position of the steered element. The curvature value is determined by the positioning system during movement of the vehicle. Due to the records, it is easy to calibrate or recalibrate the system and the invention is therefore applicable e.g. in connection with manufacturing of vehicles in small batch numbers, e.g. for one of a kind production or for retrofitting of steering components to existing vehicles.

Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.

Abstract: The present invention provides an anti-oxidant composition comprising a cyclic compound having formula I or a derivative thereof, wherein R1 and R2 are indepednetly selected from —OH, ?O, wherein R3 is a substituent comprising an —OH group; and wherein R4 and R5 are other than H; with the proviso that the compound is other than ascorbic acid.

Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.

Abstract: A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.

Abstract: A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase are derivable from Bacillus species.