Abstract: The present disclosure provides isolated monoclonal antibodies (e.g., humanized and human monoclonal antibodies), or antigen-binding fragments thereof, that specifically bind to human natural killer cell inhibitory receptor group 2A (NKG2A) protein with high affinity and exhibit therapeutically desirable functional properties, such as for the treatment of, for example, cancer. Immunoconjugates, bispecific molecules, and pharmaceutical compositions comprising the anti-NKG2A antibodies of the invention are also provided. Nucleic acid molecules encoding the antibodies, expression vectors, host cells, and methods of treatment of, for example, cancer using the antibodies are further provided. Combination therapy, in which an anti-NKG2A antibody in the present disclosure is co-administered with at least one additional agent such as another antibody (e.g., anti-PD-1, anti-PD-L1, and/or anti-CTLA-4 antibodies), is also provided.

Abstract: Dynamically managing protection groups, including: identifying a protection group of storage resources, the protection group associated with a protection group management schedule that identifies one or more protection group management operations to be performed; detecting a membership change in the protection group; and updating, in dependence upon the change in the protection group, the protection group management schedule.

Abstract: A method for determining a cooperative maneuver for an ego vehicle is provided. The method includes determining a maneuver of the ego vehicle based on traffic information in a target lane, selecting one or more cooperative vehicles to be involved in the maneuver, determining whether the maneuver of the ego vehicle and actions of the one or more cooperative vehicles trigger congestion in the target lane based on simulation of the maneuver and the actions, instructing the ego vehicle to perform the maneuver in response to determining that the maneuver of the ego vehicle and actions of the one or more cooperative vehicles do not trigger congestion, and adjusting a number of cooperative vehicles to be involved in the maneuver in response to determining that the maneuver of the ego vehicle and actions of the one or more cooperative vehicles trigger congestion.

Abstract: An industrial integrated development environment (IDE) is designed to execute on a cloud-platform or a web-based platform. The IDE includes a library of device profiles that render graphical device configuration interfaces for reading and writing values of device parameters. To ensure correct binding of an instance of a device profile invoked on a client device and the corresponding physical device on the plant floor during runtime, the IDE system assigns a unique session identifier to each communication channel between a client-side profile instance and the corresponding physical device.

Abstract: A method of applying a buttress to a surgically cut and stapled site uses an end effector with a buttress applier cartridge assembly to load one or more buttress assemblies to the end effector. The buttress assemblies each include a buttress to support a staple formed therein as well an adhesive for adhering to the end effector. The adhesive of the buttress assemblies can include a pattern to assist in both attachment to the end effector and release from the end effector after cutting and stapling a tissue site. The buttress applier cartridge can include features that accommodate end effectors having various tip configurations, including straight tips and curved or bent tips.

Abstract: Disclosed herein are polysaccharide-elastomer masterbatch compositions and processes for preparing the masterbatch compositions. One method comprises a step of a) mixing i) an aqueous polysaccharide dispersion, or ii) a basic aqueous polysaccharide solution, with a rubber latex solution containing a rubber component to form a mixture. The method further comprises the steps of: b) coagulating the mixture obtained in step a) to produce a coagulated mass; and c) drying the coagulated mass obtained in step b). The masterbatch compositions are useful in preparing rubber-containing articles.

Abstract: A mobile storage device that includes one or more coupling mechanisms. The mobile storage device includes one or more wheels coupled to one or more housings. The mobile storage device can be used on construction sites to help workers move and hold tools, equipment, and other material. The one or more coupling mechanisms are configured to engage with storage units, such as storage units within a modular system.

Abstract: A refuse vehicle includes a chassis, a first energy storage device, a body, an electric power take-off system, and a subsystem coupled to the body and moveable using hydraulic power from the electric power take-off system. The first energy storage device (e.g., a battery) is supported by the chassis and is configured to provide electrical power to a prime mover. Activation of the prime mover selectively drives the refuse vehicle. The body is configured for storing refuse, and is supported by the chassis. The electric power take-off system is positioned on the body and includes an electric motor, a second energy storage device configured to provide electric power to the electric motor, and a hydraulic pump that is drive by the electric motor. The electric motor drives the hydraulic pump to convert the electrical power into hydraulic power.

Abstract: A content addressable memory cell includes a first floating body transistor and a second floating body transistor. The first floating body transistor and the second floating body transistor are electrically connected in series through a common node. The first floating body transistor and the second floating body transistor store complementary data.

Abstract: An adjustable stroke device for a random orbital machine has a housing with a central axis and a wall defining a cavity. At least one counterweight is movably disposed at least partially within the cavity. A mounting assembly is disposed at least partially within the cavity. The mounting assembly has a workpiece attachment mechanism. A stroke adjuster couples the at least one counterweight with the mounting assembly. The stroke adjuster enables the at least one counterweight and mounting assembly to move with respect to one another such that a distance between the at least one counterweight and the mounting assembly may be variably adjusted which, in turn, variably adjust a stroke radius of the workpiece attachment mechanism with respect to the central axis of the housing. The stroke adjuster has an adjuster ring and a cam mechanism secured with the adjuster ring.

Abstract: A copolymer of ethylene and hydrolysable silane includes from 0.1 wt % to 5.0 wt % hydrolysable silane groups and has a Mz(abs)/Mw(abs) of less than or equal to 9.5; a ratio of Mz(abs)/Mw(abs) to polydispersity of less than or equal to 1.5; a polydispersity of 6.6 or greater; a Density×Polydispersity of 6.0 or greater; or an Amorphous Content at Room Temperature×Polydispersity of 360 or greater. Methods for forming a moisture-crosslinkable polymer composition include forming a copolymer of ethylene and hydrolysable silane at a polymerization temperature of greater than or equal to 180° C. to less than or equal to 400° C. at a pressure from 5,000 psi to 50,000 psi; and adding a silanol condensation catalyst to the copolymer of ethylene and hydrolysable silane.

Abstract: A contactor includes a housing and first and second fixed contacts coupling to the housing having mating ends received in the cavity of the housing and terminating ends outside of the housing. A movable contact is movable within the cavity between a mated position and an unmated position that engages the mating end of the second fixed contact in the mated position and is separated from the second fixed contact in the unmated position. A flexible busbar is coupled to the first mating end and coupled to the movable contact. The flexible busbar electrically connects the first fixed contact and the movable contact in both the mated position and the unmated position. A coil assembly in the cavity operates to move the movable contact between the unmated position and the mating position.

Abstract: An example receiver device to be wirelessly charged in motion includes a power receiver to receive a power beam to charge a power supply and a modulating reflector. The modulating reflector is to reflect a portion of the power beam as a reflected signal, modulate the reflected signal, and vary a direction of the reflected signal to scan an area for an example power beam transmitter device. The power beam transmitter device is to track motion of the receiver device based on modulation of the reflected signal and to cooperate with other power beam transmitter devices to prioritize distribution of power among a plurality of receiver devices. An example system for wireless charging of devices in motion includes a plurality of power beam transmitter devices to coordinate transmission of power beams to a receiver device based on the motion of the receiver device.

Abstract: A routing system for implementing a service and topology exchange protocol (STEP) includes a primary STEP server configured to maintain a STEP repository and a plurality of routers, with each router including a STEP client in communication with the primary STEP server. The STEP client of each router is configured to transmit, using STEP, STEP documents containing service and topology state information for at least one route or service available through the router to the primary STEP server for storage in the STEP repository. The primary STEP server is configured to transmit to the STEP client of each router, using STEP, service and topology state information from the STEP repository for at least one other router based on configured relationships between routers. Each router is configured to make routing decisions based at least in part on the service and topology state information from the at least one other router.

Abstract: A method of waterflood management for reservoir(s) having production hydrocarbon-containing well(s) including injector well(s). A reservoir model has model parameters in a mathematical relationship relating a water injection rate to a total production rate of the production well including at least one of a hydrocarbon production rate and water production rate. A solver implements automatic differentiation utilizing training data regarding the reservoir including operational data that includes recent sensor and/or historical data for the water injection rate and the hydrocarbon production rate, and constraints for the model parameters. The solver solves the reservoir model to identify values or value distributions for the model parameters to provide a trained reservoir model. The trained reservoir model uses water injection schedule(s) for the injector well to generate predictions for the total production rate.

Abstract: Processes for producing ethylene-based polymers and oligomers from ethanol include the steps of contacting the ethanol and a catalyst to produce a reaction mixture containing ethylene, wherein a first portion of the ethanol is derived from a biomass and a second portion of the ethanol is derived from a plastic, a mixed solid waste stream, or a combination thereof, separating at least a portion of the ethylene from the reaction mixture, and contacting ethylene with a suitable polymerization or oligomerization catalyst composition to produce the ethylene polymer or ethylene oligomers. A related process for producing ethylene-based polymers and oligomers uses a first ethylene feed derived from ethanol and a second ethylene feed derived from a plastic, a mixed solid waste stream, or a combination thereof.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for distributed processing in a vehicle networking system. A node in the vehicle networking system receives sets of processed sensor data from multiple nodes in the vehicle networking system. Each set of processed sensor data is generated using a first portion of a data processing algorithm on sensor data captured by different sets of sensors of the vehicle networking system. The node performs a second portion of the data processing algorithm based on the sets of processed sensor data received from multiple nodes, yielding a set of processed aggregated sensor data. The node may use the set of processed aggregated sensor data to provide a computer managed feature and/or transmit the set of processed aggregated sensor data to other nodes in the vehicle networking system.

Abstract: The present disclosure generally relates to using voice interaction to access call functionality of a companion device. In an example process, a user utterance is received. Based on the user utterance and contextual information, the process causes a server to determine a user intent corresponding to the user utterance. The contextual information is based on a signal received from the companion device. In accordance with the user intent corresponding to an actionable intent of answering the incoming call, a command is received. Based on the command, instructions are provided to the companion device, which cause the companion device to answer the incoming call and provide audio data of the answered incoming call. Audio is outputted according to the audio data of the answered incoming call.

Abstract: A process for building a high-performance liquid flow-through plate is provided and includes providing a substrate formed of metal matrix composite (MMC) material, metallizing a surface of the substrate to reform the surface into a metallized surface, placing a braze foil on the metallized surface and executing a high-temperature and high-pressure bake whereby material of the braze foil diffuses into the metallized surface.

Abstract: Methods and apparatus are described for labeling biological particles using acoustophoresis. In a washing stage, two adjacent substreams are passed through a region having a gradient in acoustic energy density, leading to particles being driven from one substream to the other. Washed bioparticles flowing in a medium are accumulated at a trapping site by an acoustic energy barrier while the medium passes by. Accumulated particles are discharged in batches and mixed with labeling particles. The mixture is incubated in a chamber, producing labeled biological particles, which are washed in another washing stage. Processing operations are automated e.g. on a microfluidics platform. Diagnostic and therapeutic applications are disclosed, covering a range of particle types and a range of labeling types. Exemplary biological particles include cells, antibodies, or fragments thereof.