Patents by Inventor Saadyah Averick

Saadyah Averick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11999848
    Abstract: This patent document discloses a modified polymer having increased hydrophilicity and a method of preparing the same. A polyarylene ether ketone polymer having a plurality of repeating units, wherein one or more units of the plurality of repeating units contains a hydrophilic N-substituted imine, which is derived from a ketone in the one or more units.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: June 4, 2024
    Assignee: Allegheny Singer Research Institute
    Inventors: Saadyah Averick, Boyle Cheng, Andrew Kassick, Michael Oh
  • Publication number: 20230126276
    Abstract: This disclosure describes fentanyl haptens, a fentanyl hapten-carrier conjugate, methods of making the fentanyl hapten-carrier conjugate, and methods of using the fentanyl hapten-carrier conjugate including, for example, as a prophylactic vaccine to counteract toxicity from exposure to fentanyl, fentanyl derivatives, and fentanyl analogs. In some embodiments, the fentanyl hapten-carrier conjugate or a composition including the fentanyl hapten-carrier conjugate may be used in an anti-opioid vaccine.
    Type: Application
    Filed: March 12, 2021
    Publication date: April 27, 2023
    Inventors: Marco Pravetoni, Saadyah Averick, Scott Runyon
  • Publication number: 20230037593
    Abstract: A poroelastic biomaterial including a polyaryletherketone (PAEK) matrix polymer and a plurality of tortuous channels extending from one surface to another surface of the biomaterial is disclosed. Advantageously, the poroelastic biomaterial can have a porosity from about 5% to about 40% and high mechanical properties. The poroelastic biomaterials can be fabricated into orthopedic implant devices and can be used as a tissue scaffolds.
    Type: Application
    Filed: July 26, 2022
    Publication date: February 9, 2023
    Inventors: Tim HSU, Minren LIN, Saadyah AVERICK, Boyle C. CHENG
  • Patent number: 11525209
    Abstract: This patent document discloses a method of fabricating an electrically conductive fiber coated with polythiophene and a carbon material. The low-cost method is amenable to modifications to suit the practical needs in various applications.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: December 13, 2022
    Assignees: The Board of Regents for Oklahoma State University, Allegheny Singer Research Institute
    Inventors: Toby Larue Nelson, Saadyah Averick, Santosh Adhikari
  • Patent number: 11344241
    Abstract: This document discloses an electrically conductive fiber coated with polythiophene and a carbon material. Also disclosed is an article of manufacture incorporating the conductive fiber.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 31, 2022
    Assignee: Allegheny Singer Research Institute
    Inventors: Saadyah Averick, Donald M. Whiting, Bertram Richter, Boyle Cheng, Toby Larue Nelson
  • Publication number: 20220152017
    Abstract: Polymer conjugates comprising a hydrophobic biodegradable polymer covalently attached to a mu opioid receptor (MOR) antagonist are described. Biodegradable covalent nanoparticles comprising the hydrophobic biodegradable polymer covalently attached to a MOR antagonist are provided as a vehicle for the sustained delivery of the MOR antagonist. The described MOR antagonist delivery system may be used to more effectively prevent or overcome the toxic effects of synthetic opioids.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 19, 2022
    Inventors: Saadyah Averick, Andrew Kassick
  • Publication number: 20210222003
    Abstract: This patent document discloses a modified polymer having increased hydrophilicity and a method of preparing the same. A polyarylene ether ketone polymer having a plurality of repeating units, wherein one or more units of the plurality of repeating units contains a hydrophilic N-substituted imine, which is derived from a ketone in the one or more units.
    Type: Application
    Filed: February 5, 2019
    Publication date: July 22, 2021
    Inventors: Saadyah Averick, Boyle Cheng, Andrew Kassick, Michael Oh
  • Patent number: 11066366
    Abstract: Various fentanyl derivatives are described. The derivatives exhibit high binding affinity to opioid receptors, but also have decreased blood brain permeability as compared to standard fentanyl. This, the resulting derivatives can be less addictive than standard fentanyl. Methods of making such derivatives are also disclosed in this document.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 20, 2021
    Assignee: Allegheny-Singer Research Institute
    Inventors: Saadyah Averick, Ahmed Badr, Shaohua Li, Keith LeJeune
  • Patent number: 10982266
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 20, 2021
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • Publication number: 20200291570
    Abstract: This patent document discloses a method of fabricating an electrically conductive fiber coated with polythiophene and a carbon material. The low-cost method is amenable to modifications to suit the practical needs in various applications.
    Type: Application
    Filed: September 13, 2018
    Publication date: September 17, 2020
    Inventors: Toby Larue Nelson, Saadyah Averick, Santosh Adhikari
  • Publication number: 20200281497
    Abstract: This document discloses an electrically conductive fiber coated with polythiophene and a carbon material. Also disclosed is an article of manufacture incorporating the conductive fiber.
    Type: Application
    Filed: September 13, 2018
    Publication date: September 10, 2020
    Inventors: Saadyah Averick, Donald M. Whiting, Bertram Richter, Boyle Cheng, Toby Larue Nelson
  • Publication number: 20180273475
    Abstract: Various fentanyl derivatives are described. The derivatives exhibit high binding affinity to opioid receptors, but also have decreased blood brain permeability as compared to standard fentanyl. This, the resulting derivatives can be less addictive than standard fentanyl. Methods of making such derivatives are also disclosed in this document.
    Type: Application
    Filed: September 6, 2016
    Publication date: September 27, 2018
    Inventors: Saadyah Averick, Ahmed Badr, Shaohua Li, Keith LeJeune
  • Publication number: 20180142288
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 24, 2018
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • Patent number: 9790305
    Abstract: The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 17, 2017
    Assignee: Franklin and Marshall College
    Inventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
  • Patent number: 9765169
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: September 19, 2017
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Subha Ranjan Das, Saadyah Averick, Sourav K. Dey, Krzysztof Matyjaszewski
  • Publication number: 20170158836
    Abstract: A three-dimensionally ordered macroporous hydrogel for immobilizing a selected bioresponsive molecule and method of making are disclosed. The three-dimensionally ordered macroporous hydrogel comprises a crosslinked polymer that has a system of interconnected pores. The interconnected pores have a uniform pore size in the range of 50 to 5000 nm, and a plurality of first pore functional groups. The plurality of first pore functional groups is selected to immobilize a selected bioresponsive molecule. Examples of bioresponsive molecules include an enzyme; a molecule for: a protein scaffold, solid phase synthesis, nucleic acid synthesis, polypeptide synthesis, analyte detection, adsorption of analytes and measuring analyte concentrations, organic synthesis, and degradation of biologically active agents in wastewater. A method includes forming a colloidal crystal template, polymerizing a hydrogel within the pores of the colloidal crystal template, and selectively removing the colloidal crystal template.
    Type: Application
    Filed: November 25, 2014
    Publication date: June 8, 2017
    Inventors: Krzysztof Matyjaszewski, Saadyah Averick, Hongkun He
  • Publication number: 20170152336
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Application
    Filed: April 17, 2014
    Publication date: June 1, 2017
    Inventors: SUBHA RANJAN DAS, SAADYAH AVERICK, SOURAV K. DEY, Krzysztof Matyjaszewski
  • Patent number: 9650404
    Abstract: The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: May 16, 2017
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Krishnaswami Raja, Alejandra Alonso, Probal Banerjee, Sukanta Dolai, Christopher Corbo, Saadyah Averick, Amit Mogha, Shawon Debnath
  • Publication number: 20160251467
    Abstract: The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 1, 2016
    Applicant: FRANKLIN AND MARSHALL COLLEGE
    Inventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
  • Publication number: 20160075810
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Application
    Filed: April 17, 2014
    Publication date: March 17, 2016
    Inventors: SUBHA RANJAN DAS, SAADYAH AVERICK, SOURAV K. DEY, Krzysztof Matyjaszewski