Abstract: An ingestible apparatus for collecting samples from a target area of a gastrointestinal (GI) tract of a subject and/or for delivering a health-related substance thereto. An example ingestible apparatus includes a housing defining a sample compartment, a stopper configured to seal an access port, and an actuation assembly connected to the stopper. The actuation assembly is movable between a first working position where the access port is open and a second working position where the access port is sealed with the stopper. The apparatus also includes a dissolvable block configured to prevent the actuation assembly from moving between the first and second working positions until the apparatus is within a target area of the GI tract. The actuation assembly is configured, in the second working position, to apply a linear force at an interface between the stopper and a sealing surface to seal the access port with the stopper.

Abstract: Oral appliances, and systems and methods, which include oral appliances are described herein. An example oral appliance device for treatment of a sleep disorder or condition in a subject can include an upper portion configured to receive at least one maxillary tooth of the subject, and a lower portion configured to receive at least one mandibular tooth of the subject. The upper and lower portions are engageable such that the portions maintain a restricted orientation relative to each other when engaged, and the engaged restricted orientation is configured to maintain the mandible of the subject in a predetermined clinically beneficial orientation relative to the maxilla.

Abstract: Oral appliances, and systems and methods, which include oral appliances are described herein. An example oral appliance device for treatment of a sleep disorder or condition in a subject can include an upper portion configured to receive at least one maxillary tooth of the subject, and a lower portion configured to receive at least one mandibular tooth of the subject. The upper and lower portions are engageable such that the portions maintain a restricted orientation relative to each other when engaged, and the engaged restricted orientation is configured to maintain the mandible of the subject in a predetermined clinically beneficial orientation relative to the maxilla.

Abstract: Provided herein are oral appliances and methods of using oral appliances for treatment of sleep disorders and conditions.