Patents by Inventor Sabine Hallenberger

Sabine Hallenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amide compounds as boosters of antivirals
    Patent number: 8664391
    Abstract: The present invention relates to compounds of formula (I) that have CYP450 inhibiting properties and are useful as boosting agents when used with HIV treatments. These compounds are represented by formula including the salts and stereoisomeric forms thereof, wherein R1 is 5-thiazolyl or 3-pyridinyl; R2 is iso-butyl, 2,2-dimethylpropyl; 2-hydroxy-2-methyl-propyl or cyclohexylmethyl; R3 is phenyl optionally substituted with one or more halogens, trifluoromethyl, C1-6-alkyl or C1-6-alkoxy wherein optionally two of said alkoxy groups are be linked to each other to form a 5 or 6-membered ring; heteroaryl; C3-7cycloalkyl optionally substituted with one or more halogens; C1-6alkyl optionally substituted with heteroaryl; —O—CH2— (heteroaryl). As boosting agents they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered, or improve the bioavailability of certain drugs.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: March 4, 2014
    Assignee: Janssen R&D Ireland Ltd
    Inventors: Tim Hugo Maria Jonckers, Wim Bert Griet Schepens, Geerwin Yvonne Paul Haché, Beate Sabine Hallenberger, Jennifer Chiyomi Sasaki, Judith Eva Baumeister, Gerben Albert Van 'T Klooster
  • Amide compounds as boosters of antivirals
    Patent number: 8350048
    Abstract: The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions are also provided.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: January 8, 2013
    Assignee: Janssen R&D Ireland
    Inventors: Tim Hugo Maria Jonckers, Wim Bert Griet Schepens, Geerwin Yvonne Paul Haché, Beate Sabine Hallenberger, Jennifer Chiyomi Sasaki, Judith Eva Baumeister, Gerben Albert Van 'T Klooster
  • AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS
    Publication number: 20110195969
    Abstract: The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions comprising these compounds are also provided.
    Type: Application
    Filed: October 7, 2009
    Publication date: August 11, 2011
    Inventors: Tim Hugo Maria Jonckers, Wim Bert Griet Schepens, Geerwin Yvonne Paul Haché, Beate Sabine Hallenberger, Jennifer Chiyomi Sasaki, Judith Eva Baumeister, Gerben Albert Van ' T Klooster
  • AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS
    Publication number: 20100305073
    Abstract: The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions are also provided.
    Type: Application
    Filed: December 5, 2008
    Publication date: December 2, 2010
    Inventors: Tim Hugo Maria Jonckers, Wim Bert Griet Schepens, Geerwin Yvonne Paul Haché, Beate Sabine Hallenberger, Jennifer Chiyomi Sasaki, Judith Eva Baumeister, Gerben Albert Van 'T Klooster
  • Arylsulfonamides as antiviral agents
    Patent number: 7115612
    Abstract: The present invention relates to novel sulphonamides of the general formula (I) in which the substituents R1, R2, R3, R4 and A and X are as defined in claim 1 and other claims, and also to processes for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: October 3, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Tobias Wunberg, Wolfgang Bender, Peter Eckenberg, Sabine Hallenberger, Kerstin Henninger, Jörg Keldenich, Armin Kern, Siegfried Raddatz, Jürgen Reefschläger, Gunter Schmidt, Holger Zimmermann, Franz Zumpe, Martin Radtke
  • Hetrocyclic aryl sulphonamides
    Patent number: 7115636
    Abstract: The invention relates to novel sulfonamides of general formula (I) where the substituents R1, R2, R3, R4, A and X have the given meanings, pharmaceutical compositions containing them, and a method of using them as antiviral agents, in particular against cytomegaloviruses.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: October 3, 2006
    Assignee: Bayer Healthcare AG
    Inventors: Tobias Wunberg, Wolfgang Bender, Peter Eckenberg, Sabine Hallenberger, Kerstin Henninger, Jörg Keldenich, Armin Kern, Siegfried Raddatz, Jürgen Reefschläger, Gunter Schmidt, Holger Zimmermann, Franz Zumpe, Martin Radtke
  • Hetrocyclic aryl sulphonamides
    Publication number: 20050085549
    Abstract: The invention relates to novel sulfonamides of general formula (I) where the substituents R1, R2, R3, R4, A and X have the given meanings, pharmaceutical compositions containing them, and a method of using them as antiviral agents, in particular against cytomegaloviruses.
    Type: Application
    Filed: July 24, 2002
    Publication date: April 21, 2005
    Inventors: Tobias Wunberg, Wolfgang Bender, Peter Eckenberg, Sabine Hallenberger, Kerstin Henninger, Jorg Keldenich, Armin Kern, Siegfried Raddatz, Jurgen Reefschlager, Gunter Schmidt, Holger Zimmermann, Franz Zumpe, Martin Radtke
  • Pyridazinone
    Publication number: 20050059658
    Abstract: The invention relates to novel compounds, to a method for the production of said compounds and to the use thereof as medicaments, more particularly as antiviral agents, especially against cytomegalovirus.
    Type: Application
    Filed: June 17, 2002
    Publication date: March 17, 2005
    Inventors: Tobias Wunberg, Ulrich Betz, Sabine Hallenberger, Gerald Kleymann, Thomas Lampe, Susanne Nikolic, Jurgen Reefschlager, Franz Zumpe, Marcus Bauser, Wolfgang Bender, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Axel Jensen, Jorg Keldenich, Holger Zimmermann
  • Arylsulfonamides as antiviral agents
    Publication number: 20040176374
    Abstract: The present invention relates to novel sulphonamides of the general formula (I) 1
    Type: Application
    Filed: April 12, 2004
    Publication date: September 9, 2004
    Inventors: Tobias Wunberg, Wolfgang Bender, Peter Eckenberg, Sabine Hallenberger, Kerstin Henninger, Jorg Keldenich, Armin Kern, Siegfried Raddatz, Jurgen Reefschlager, Gunter Schmidt, Holger Zimmermann, Franz Zumpe, Martin Radtke
  • Substituted indole sulfonamides as anitviral agents
    Patent number: 6498183
    Abstract: The present invention relates to novel compounds which are suitable as pharmaceuticals, to processes for their preparation and to their use as pharmaceuticals, in particular as antiviral agents.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: December 24, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Bender, Peter Eckenberg, Siegfried Goldmann, Michael Härter, Sabine Hallenberger, Jürgen Reefschläger, Jörg Trappe, Olaf Weber
  • Naphthyl-substituted and anilide-substituted sulfonamides
    Patent number: 6417181
    Abstract: The present invention relates to new naphthyl- and anilide-substituted sulphonamides of the general formula (I) in which the substituents A, D, E, G, R1, R2, R3, R4 and X have the meanings indicated, and to processes for their preparation and their use as antiviral agents, in particular against cytomegaloviruses.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 9, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Bender, Jürgen Reefschläger, Peter Eckenberg, Siegfried Goldmann, Michael Härter, Sabine Hallenberger, Jörg Trappe, Olaf Weber