Patents by Inventor Sabine Lahja Flitsch

Sabine Lahja Flitsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Sialylating a Protein
    Publication number: 20220251619
    Abstract: The invention relates to a method of increasing the number of ?2,3,-?2,6-disialylgalactose N-glycans on a glycoprotein by incubating an ?2,3-sialylated glycoprotein with an ?2,6-sialyltransferase and a sialic acid source. Also provided is a recombinant glycoprotein comprising at least one ?2,3,-?2,6-disialylgalactose N-glycan. In a particular embodiment, the recombinant glycoprotein is alpha-1 antitrypsin (AAT).
    Type: Application
    Filed: March 23, 2020
    Publication date: August 11, 2022
    Inventors: Sern Farh Matthew Choo, Terry Nguyen-Khuong, Edward George Pallister, Say Kong Ng, Sabine Lahja Flitsch
  • Modified peptide derivatives and methods of use thereof
    Patent number: 7223795
    Abstract: The present invention relates to a compound of formula I wherein (i) when a and c are double bonds, R2 is absent, b is a single bond, R1 is or (ii) when a and c are single bonds, b is a double bond, and R1 is H, R2 is wherein the substituents are as defined in the specification.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: May 29, 2007
    Assignee: Cyclacel Limited
    Inventors: Malcolm Douglas Walkinshaw, Paul Taylor, Nicholas John Turner, Sabine Lahja Flitsch
  • Modified peptide derivatives and methods of use thereof
    Publication number: 20040077829
    Abstract: The present invention relates to a compound of formula I 1
    Type: Application
    Filed: June 12, 2003
    Publication date: April 22, 2004
    Inventors: Malcolm Douglas Walkinshaw, Paul Taylor, Nicholas John Turner, Sabine Lahja Flitsch
  • Solid phase organic synthesis
    Patent number: 6492136
    Abstract: A method of synthesis of a material corresponding to the general formula: R3—X—H characterized in that it comprises a material corresponding to the following general formula: being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R″), C(O)O, S, C(O)N(H) or C(O)N(R″), R″ being a non-interfering group; and Support represents a solid support.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: December 10, 2002
    Assignee: Genzyme Limited
    Inventors: Sabine Lahja Flitsch, Nicholas John Turner
  • Mutant mono-oxygenase cytochrome P450cam
    Patent number: 6117661
    Abstract: A mutant of the mono-oxygenase cytochrome P450cam in which the cysteine residue at position 334 is removed.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: September 12, 2000
    Assignee: BG plc
    Inventors: Luet-Lok Wong, Sabine Lahja Flitsch, Darren Paul Nickerson, Alwyn James Hart
  • Mutant mono-oxygenase cytochrome P-450 .sub.cam
    Patent number: 6100074
    Abstract: A mutant of the mono-oxygenase cytochrome P-450.sub.cam in which the tyrosine residue at position 96 and/or the cysteine residue at positon 334 is replaced by the residue of any amino acid except phenylalanine.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: August 8, 2000
    Assignee: BG plc
    Inventors: Sabine Lahja Flitsch, Darren Paul Nickerson, Luet-Lok Wong