Patents by Inventor Sabine Lohmann
Sabine Lohmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11155852Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.Type: GrantFiled: July 23, 2018Date of Patent: October 26, 2021Assignee: Roche Molecular Systems, Inc.Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
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Publication number: 20180346964Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.Type: ApplicationFiled: July 23, 2018Publication date: December 6, 2018Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
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Patent number: 10059980Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.Type: GrantFiled: January 22, 2014Date of Patent: August 28, 2018Assignee: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
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Publication number: 20150353992Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.Type: ApplicationFiled: January 22, 2014Publication date: December 10, 2015Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
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Patent number: 8507201Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.Type: GrantFiled: November 17, 2009Date of Patent: August 13, 2013Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems, Inc.Inventors: Franklin R Cockerill, III, Robin Patel, Lynne M Sloan, Sabine Lohmann, Ulrike Salat
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Publication number: 20100227322Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.Type: ApplicationFiled: November 17, 2009Publication date: September 9, 2010Inventors: Franklin R. Cockerill, III, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
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Publication number: 20100221715Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.Type: ApplicationFiled: November 17, 2009Publication date: September 2, 2010Inventors: Franklin R. Cockerill, III, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
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Patent number: 7691571Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.Type: GrantFiled: January 9, 2004Date of Patent: April 6, 2010Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems, Inc.Inventors: Franklin R. Cockerill, III, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
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Publication number: 20040265853Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.Type: ApplicationFiled: January 9, 2004Publication date: December 30, 2004Inventors: Franklin R. Cockerill, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
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Patent number: 6503720Abstract: Methods are provided for quantifying the concentration of a nucleic acid in a nucleic acid sample. The methods include contacting the nucleic acid sample with an amplifying agent, amplifying at least one predetermined locus of the nucleic acid by subjecting the sample to a number of amplification, generating an amplification curve or array, calculating the first, second or n th order derivative of the amplification curve or array, determining a maximum, minimum, or zero value of the derivative, and using the maximum, minimum, or zero value to calculate the initial concentration of the nucleic acid in the nucleic acid sample.Type: GrantFiled: February 20, 2001Date of Patent: January 7, 2003Assignees: Roche Diagnostics GmbH, University of Utah Research FoundationInventors: Carl T. Wittwer, Martin Gutekunst, Sabine Lohmann
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Publication number: 20020028452Abstract: Methods are provided for quantifying the concentration of a nucleic acid in a nucleic acid sample. The methods include contacting the nucleic acid sample with an amplifying agent, amplifying at least one predetermined locus of the nucleic acid by subjecting the sample to a number of amplification, generating an amplification curve or array, calculating the first, second or n th order derivative of the amplification curve or array, determining a maximum, minimum, or zero value of the derivative, and using the maximum, minimum, or zero value to calculate the initial concentration of the nucleic acid in the nucleic acid sample.Type: ApplicationFiled: February 20, 2001Publication date: March 7, 2002Inventors: Carl T. Wittwer, Martin Gutekunst, Sabine Lohmann
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Patent number: 6303305Abstract: The invention provides a new method for the quantification of a nucleic acid, wherein in a first step, the nucleic acid is amplified by an amplifying agent. Subsequently, first, second or n th order derivatives is calculated. The obtained value can then be used to calculate the initial concentration of the analyte.Type: GrantFiled: March 30, 1999Date of Patent: October 16, 2001Assignees: Roche Diagnostics, GmbH, University of Utah Research FoundationInventors: Carl T. Wittwer, Martin Gutekunst, Sabine Lohmann