Patents by Inventor Sabine Lohmann

Sabine Lohmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180346964
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Application
    Filed: July 23, 2018
    Publication date: December 6, 2018
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Patent number: 10059980
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: August 28, 2018
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Publication number: 20150353992
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Application
    Filed: January 22, 2014
    Publication date: December 10, 2015
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Patent number: 8507201
    Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: August 13, 2013
    Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems, Inc.
    Inventors: Franklin R Cockerill, III, Robin Patel, Lynne M Sloan, Sabine Lohmann, Ulrike Salat
  • Publication number: 20100227322
    Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.
    Type: Application
    Filed: November 17, 2009
    Publication date: September 9, 2010
    Inventors: Franklin R. Cockerill, III, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
  • Publication number: 20100221715
    Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.
    Type: Application
    Filed: November 17, 2009
    Publication date: September 2, 2010
    Inventors: Franklin R. Cockerill, III, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
  • Patent number: 7691571
    Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: April 6, 2010
    Assignees: Mayo Foundation for Medical Education and Research, Roche Molecular Systems, Inc.
    Inventors: Franklin R. Cockerill, III, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
  • Publication number: 20040265853
    Abstract: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further provided by the invention.
    Type: Application
    Filed: January 9, 2004
    Publication date: December 30, 2004
    Inventors: Franklin R. Cockerill, Robin Patel, Lynne M. Sloan, Sabine Lohmann, Ulrike Salat
  • Patent number: 6503720
    Abstract: Methods are provided for quantifying the concentration of a nucleic acid in a nucleic acid sample. The methods include contacting the nucleic acid sample with an amplifying agent, amplifying at least one predetermined locus of the nucleic acid by subjecting the sample to a number of amplification, generating an amplification curve or array, calculating the first, second or n th order derivative of the amplification curve or array, determining a maximum, minimum, or zero value of the derivative, and using the maximum, minimum, or zero value to calculate the initial concentration of the nucleic acid in the nucleic acid sample.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: January 7, 2003
    Assignees: Roche Diagnostics GmbH, University of Utah Research Foundation
    Inventors: Carl T. Wittwer, Martin Gutekunst, Sabine Lohmann
  • Publication number: 20020028452
    Abstract: Methods are provided for quantifying the concentration of a nucleic acid in a nucleic acid sample. The methods include contacting the nucleic acid sample with an amplifying agent, amplifying at least one predetermined locus of the nucleic acid by subjecting the sample to a number of amplification, generating an amplification curve or array, calculating the first, second or n th order derivative of the amplification curve or array, determining a maximum, minimum, or zero value of the derivative, and using the maximum, minimum, or zero value to calculate the initial concentration of the nucleic acid in the nucleic acid sample.
    Type: Application
    Filed: February 20, 2001
    Publication date: March 7, 2002
    Inventors: Carl T. Wittwer, Martin Gutekunst, Sabine Lohmann
  • Patent number: 6303305
    Abstract: The invention provides a new method for the quantification of a nucleic acid, wherein in a first step, the nucleic acid is amplified by an amplifying agent. Subsequently, first, second or n th order derivatives is calculated. The obtained value can then be used to calculate the initial concentration of the analyte.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: October 16, 2001
    Assignees: Roche Diagnostics, GmbH, University of Utah Research Foundation
    Inventors: Carl T. Wittwer, Martin Gutekunst, Sabine Lohmann