Abstract: The present invention relates to methods for detecting a target in a sample using mutated nanobodies, wherein an amino acid present in the loop of the FR1 region of framework of the nanobodies is mutated to cysteine.

Abstract: A method for generating vapour bubbles in an object comprises introducing a composition into the object, the composition comprising carbon-based nano- or microparticles that can couple with a photon wave of electromagnetic radiation. The method also comprises irradiating said object using electromagnetic radiation. The irradiation thereby is adapted for using a set of carbon-based nano- or microparticles for subsequently forming first vapour bubbles and at least second vapour bubbles using the same carbon-based nano- or microparticles.

Abstract: The present invention relates to a cutaneous device (2) for the storage and release of molecules, in particular therapeutic molecules, comprising: —a support (6), —a matrix (8) configured to store and release the molecules as a function of the temperature, and —an electro-resistive layer, disposed between the support and the matrix, intended to be subjected to a voltage and comprising at least one thin microporous and/or nanoporous metal layer. The present invention also relates to a transcutaneous delivery device and the corresponding methods of manufacture and use.

Abstract: A method for generating vapour bubbles in an object comprises introducing a composition into the object, the composition comprising carbon-based nano- or microparticles that can couple with a photon wave of electromagnetic radiation. The method also comprises irradiating said object using electromagnetic radiation. The irradiation thereby is adapted for using a set of carbon-based nano- or microparticles for subsequently forming first vapour bubbles and at least second vapour bubbles using the same carbon-based nano- or microparticles.

Abstract: The invention substantially relates to an imaging system for the chemical, biological or biochemical analysis of a sample (10), comprising a device (40) for holding the sample (10), a device (20) for optical detection, a lighting device (30), liable to emit a monochromatic light beam, and a wide aperture objective (f1), It is substantially characterized in that the objective (f1) is configured for, downstream of the sample (10): focusing the excitation light beam reflected at a point (C) located in the focal plane (FF) of said objective (f1), and transforming the retransmitted or scattered light beam into a quasi-parallel beam, and in that the system further comprises a device (70) for selectively blocking the collected light beam by said objective (f1).

Abstract: Molecules of a coupling layer composition in a semiconductor device are bidimensionally polymerized in order to provide enhanced moisture blocking effect, particularly when the coupling layer is formed on a porous layer, such as a porous dielectric layer. The deposition of the coupling layer on the underlying structure and/or the cross-polymerization of the coupling layer composition and/or a final metallization can be photo-activated, especially, but not only, using an ultraviolet light.

Abstract: The invention substantially relates to an imaging system for the chemical, biological or biochemical analysis of a sample (10), comprising a device (40) for holding the sample (10), a device (20) for optical detection, a lighting device (30), liable to emit a monochromatic light beam, and a wide aperture objective (f1), It is substantially characterized in that the objective (f1) is configured for, downstream of the sample (10): focusing the excitation light beam reflected at a point (C) located in the focal plane (FF) of said objective (f1), and transforming the retransmitted or scattered light beam into a quasi-parallel beam, and in that the system further comprises a device (70) for selectively blocking the collected light beam by said objective (f1).

Abstract: The Invention relates to a method for producing a solid support coated by a metal Layer to which an SiOx layer provided with a uniform and stable thickness is applied, wherein said solid support makes it possible to determine the pretense of a compound on the surface thereof by means of Surface Plasmon Resonance (?SPR ?).

Abstract: A method of detecting substances or reactions of substances in a sample, comprising: (i) providing a layer (CS) based on hydrogenated or unhydrogenated amorphous silicon with attached probes, (ii) bringing the layer (CS) in contact with the sample that may contain the substances that bind specifically to or reacts specifically with the probes, under appropriate conditions for the substances to bind to or react with the probes; (iii) optionally removing non-specifically bound or non-specifically reactive substances; and (iv) detecting the presence or amount of the specifically bound or reactive substances in the sample by surface plasmon resonance (SPR) and/or fluorescence, is described.

Abstract: One subject of the present invention is a transparent solid support coated with at least one layer of metal and with at least one layer of transparent conductive oxide (TCO), especially tin-doped indium oxide (ITO) in order to form a solid support that can be used at the same time or independently for detection by SPR and by an electrochemical method. The invention comprises a process for producing such supports, especially by cathode sputtering using a device comprising a radiofrequency (RF) generator, this device also being included in the invention. Another subject of the invention is a kit and a method for detection or identification of an organic or mineral compound by surface plasmon resonance (SPR) and/or electrochemical plasmon resonance comprising or using such supports.

Abstract: Molecules of a coupling layer composition in a semiconductor device are bidimensionally polymerized in order to provide enhanced moisture blocking effect, particularly when the coupling layer is formed on a porous layer, such as a porous dielectric layer. The deposition of the coupling layer on the underlying structure and/or the cross-polymerization of the coupling layer composition and/or a final metallization can be photo-activated, especially, but not only, using an ultraviolet light.

Abstract: The Invention relates to a method for producing a solid support coated by a metal Layer to which an SiOx layer provided with a uniform and stable thickness is applied, wherein said solid support makes it possible to determine the pretense of a compound on the surface thereof by means of Surface Plasmon Resonance (?SPR ?).

Abstract: An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement. The plurality of electrodes are substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component. The insulator is disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.

Abstract: An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement. The plurality of electrodes are substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component. The insulator is disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.