Patents by Inventor Sabrina Dallavalle

Sabrina Dallavalle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retinoid derivatives with antitumor activity
    Patent number: 11819484
    Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: November 21, 2023
    Assignee: BIOGEM S.C. A R.L.
    Inventors: Claudio Pisano, Sabrina Dallavalle, Raffaella Cincinelli, Lucio Merlini
  • PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE
    Publication number: 20220281835
    Abstract: Phenol derivatives of general formula (I) and (II), wherein meanings of the substituents are indicated in the description, their pharmaceutically acceptable salts, together with the processes for their preparation, their use as antimicrobial, antibacterial, bactericide agents and the corresponding pharmaceutical compositions are disclosed.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 8, 2022
    Inventors: Sabrina DALLAVALLE, Claudio PISANO, Massimiliano FLORIO, Claudio CAMPONESCHI
  • Retinoid derivatives with antitumor activity
    Patent number: 11364216
    Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
    Type: Grant
    Filed: October 24, 2020
    Date of Patent: June 21, 2022
    Assignee: BIOGEM S.C. A R.L.
    Inventors: Claudio Pisano, Sabrina Dallavalle, Raffaella Cincinelli, Lucio Merlini
  • RETINOID DERIVATIVES WITH ANTITUMOR ACTIVITY
    Publication number: 20220168252
    Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
    Type: Application
    Filed: December 6, 2021
    Publication date: June 2, 2022
    Inventors: Claudio PISANO, Sabrina DALLAVALLE, Raffaella CINCINELLI, Lucio MERLINI
  • RETINOID DERIVATIVES WITH ANTITUMOR ACTIVITY
    Publication number: 20210052530
    Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
    Type: Application
    Filed: October 24, 2020
    Publication date: February 25, 2021
    Inventors: Claudio PISANO, Sabrina DALLAVALLE, Raffaella CINCINELLI, Lucio MERLINI
  • Retinoid derivatives with antitumor activity
    Patent number: 10905668
    Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: February 2, 2021
    Assignee: BIOGEM S.C. A R.L.
    Inventors: Claudio Pisano, Sabrina Dallavalle, Raffaella Cincinelli, Lucio Merlini
  • RETINOID DERIVATIVES WITH ANTITUMOR ACTIVITY
    Publication number: 20200009091
    Abstract: The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 9, 2020
    Inventors: Claudio PISANO, Sabrina DALLAVALLE, Raffaella CINCINELLI, Lucio MERLINI
  • 4-oxo-N-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer
    Patent number: 10093621
    Abstract: The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein: X is —COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO— wherein R2 is straight or branched C1-C10 alkyl, for use as antitumoral agents.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: October 9, 2018
    Assignee: FONDAZIONE IRCCS INSTITUTO NAZIONALE DEI TUMORI
    Inventors: Maria Grazia Daidone, Valentina Appierto, Paola Tiberio, Sabrina Dallavalle, Loana Musso, Elisa Niccolini
  • 4-OXO-N-(4-HYDROXYPHENYL)RETINAMIDE DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
    Publication number: 20170253560
    Abstract: The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein: X is —COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO— wherein R2 is straight or branched C1-C10 alkyl, for use as antitumoral agents.
    Type: Application
    Filed: September 16, 2015
    Publication date: September 7, 2017
    Inventors: Maria Grazia DAIDONE, Valentina APPIERTO, Paola TIBERIO, Sabrina DALLAVALLE, Loana MUSSO, Elisa NICCOLINI
  • Retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties
    Patent number: 8530517
    Abstract: The present invention relates to new retinoid derivatives of formula I and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumors, metastatic cancer, diabetic retinopathy, psoriasis, chronic inflammatory diseases or atherosclerosis.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 10, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Walter Cabri, Giuseppe Giannini, Gianfranco Battistuzzi, Domenico Alloatti, Claudio Pisano, Sabrina Dallavalle, Tiziana Brunetti
  • Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities
    Patent number: 8101793
    Abstract: Are described compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: January 24, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Lucio Merlini, Sabrina Dallavalle, Sergio Penco, Giuseppe Giannini, Claudio Pisano, Loredana Vesci
  • RETINOID DERIVATIVES ENDOWED WITH CYTOTOXIC AND/OR ANTIANGIOGENIC PROPERTIES
    Publication number: 20110312965
    Abstract: The present invention relates to new retinoid derivatives of formula I and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumours, metastatic cancer, diabetic retinopathy, psoriasis, chronic inflammatory diseases or atherosclerosis.
    Type: Application
    Filed: December 21, 2009
    Publication date: December 22, 2011
    Inventors: Walter Cabri, Giuseppe Giannini, Gianfranco Battistuzzi, Domenico Alloatti, Claudio Pisano, Sabrina Dallavalle, Tiziana Brunetti
  • Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives
    Patent number: 7728039
    Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumor, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumors.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 1, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Franco Zunino, Sabrina Dallavalle, Lucio Merlini, Sergio Penco
  • Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents
    Patent number: 7705012
    Abstract: Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: April 27, 2010
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Instituto Nazionale per lo Studio e la Cura Dei Tumori
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Ornella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists
    Patent number: 7589099
    Abstract: Compounds of Formula (I) are described: in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: September 15, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Ming Hong, Sabrina Dallavalle, Lucio Merlini, Maria Ornella Tinti, Franco Zunino
  • Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives
    Publication number: 20080319082
    Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumour, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumours.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 25, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Franco Zunino, Sabrina Dallavalle, Lucio Merlini, Sergio Penco
  • Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities
    Patent number: 7449495
    Abstract: Described and claimed are compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: November 11, 2008
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Sabrina Dallavalle, Lucio Merlini, Claudio Pisano, Loredana Vesci, Giuseppe Giannini, Sergio Penco
  • 7-imino derivatives of camptothecin having antitumor activity
    Patent number: 7351714
    Abstract: Camptothecin derivatives of camptothecin of formula (I) wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: April 1, 2008
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Istituto Nazionale per Lo Studio E La Cura Dei Tumori
    Inventors: Sabrina Dallavalle, Sergio Penco, Claudio Pisano, Franco Zunino
  • Camptothecins Conjugated in Position 7 to Cyclic Peptides as Cytostatic Agents
    Publication number: 20080033003
    Abstract: Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Application
    Filed: May 4, 2005
    Publication date: February 7, 2008
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Omella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities
    Publication number: 20080021088
    Abstract: Described and claimed are compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 24, 2008
    Inventors: Sabrina Dallavalle, Lucio Merlini, Claudio Pisano, Loredana Vesci, Giuseppe Giannini, Sergio Penco