Patents by Inventor Sabrina Esposito

Sabrina Esposito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the industrial-scale purification of gamma globulins from human plasma for industrial applications
    Patent number: 8933204
    Abstract: The invention relates to a novel, industrial-scale process for the purification of gamma-immunoglobulins (IgG) starting from plasma or fractions thereof. The method involves two chromatographic steps, i.e. a cation exchange capture chromatography, and then a polishing anion exchange chromatography, ensuring a highly purified end product, which contains no aggregates, and high yields. The process also involves a virus inactivation step by means of a solvent/detergent treatment to inactivate the viruses with a lipid envelope, and a virus removal step by nanofiltering to ensure the removal of the non-enveloped viruses.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: January 13, 2015
    Assignee: Kedrion S.p.A.
    Inventors: Claudia Nardini, Andrea Morelli, Claudio Farina, Sabrina Esposito, Alessandra Lazzarotti, Arianna Petrucci
  • NEW PROCESS FOR THE INDUSTRIAL-SCALE PURIFICATION OF GAMMA GLOBULINS FROM HUMAN PLASMA FOR INDUSTRIAL APPLICATIONS
    Publication number: 20120316323
    Abstract: The invention relates to a novel, industrial-scale process for the purification of gamma-immunoglobulins (IgG) starting from plasma or fractions thereof. The method involves two chromatographic steps, i.e. a cation exchange capture chromatography, and then a polishing anion exchange chromatography, ensuring a highly purified end product, which contains no aggregates, and high yields. The process also involves a virus inactivation step by means of a solvent/detergent treatment to inactivate the viruses with a lipid envelope, and a virus removal step by nanofiltering to ensure the removal of the non-enveloped viruses.
    Type: Application
    Filed: December 28, 2010
    Publication date: December 13, 2012
    Inventors: Claudia Nardini, Andrea Morelli, Claudio Farina, Sabrina Esposito, Alessandra Lazzarotti, Arianna Petrucci