Patents by Inventor Sabrina Funke

Sabrina Funke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high throughput screening
    Patent number: 9862971
    Abstract: The invention relates to the pseudotyping of retroviral vectors with heterologous envelope proteins derived from the Paramyxoviridae family, genus Morbillivirus, and various uses of the resulting vector particles. The present invention is based on the unexpected and surprising finding that the incorporation of morbillivirus F and H proteins having truncated cytoplasmic tails into lentiviral vector particles, and the complex interaction of these two proteins during cellular fusion, allows for a superior and more effective transduction of cells. Moreover, these pseudotyped vector particles allow the targeted gene transfer into a given cell type of interest by modifying a mutated and truncated H protein with a single-chain antibody or ligand directed against a cell surface marker of the target cell.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: January 9, 2018
    Assignee: BUNDESREPUBLIK DEUTSCHLAND, LETZTVERTRETEN DURCH DEN PRASIDENTEN DES PAUL-EHRLICH-INSTITUTS
    Inventors: Christian Buchholz, Sabrina Funke, Klaus Cichutek, Roberto Cattaneo
  • PSEUDOTYPING OF RETROVIRAL VECTORS, METHODS FOR PRODUCTION AND USE THEREOF FOR TARGETED GENE TRANSFER AND HIGH THROUGHPUT SCREENING
    Publication number: 20100189690
    Abstract: The invention relates to the pseudotyping of retroviral vectors with heterologous envelope proteins derived from the Paramyxoviridae family, genus Morbillivirus, and various uses of the resulting vector particles. The present invention is based on the unexpected and surprising finding that the incorporation of morbillivirus F and H proteins having truncated cytoplasmic tails into lentiviral vector particles, and the complex interaction of these two proteins during cellular fusion, allows for a superior and more effective transduction of cells. Moreover, these pseudotyped vector particles allow the targeted gene transfer into a given cell type of interest by modifying a mutated and truncated H protein with a single-chain antibody or ligand directed against a cell surface marker of the target cell.
    Type: Application
    Filed: September 26, 2007
    Publication date: July 29, 2010
    Applicant: Bundesrepublik Deutschland, letztvertreten durch d en Prasidenten des Paul-Ehrich-Instituts
    Inventors: Christian Buchholz, Sabrina Funke, Klaus Cichutek, Roberto Cattaneo