Abstract: A TPN solution to be prepared before using which comprises two separate infusions of an amino acid-infusion and a saccharide-infusion wherein both of said infusions contain no sulfite ion, either one of said infusions contains a water-soluble vitamin B, a pH of the infusion containing a water-soluble vitamin B is acidic and a pH of the TPN solution prepared by mixing both infusions is neutral. According to the TPN solution of the present invention, a water-soluble vitamin B can be stably preserved in a TPN solution for a long term though it has been recognized that the water-soluble vitamin B could not be contained in a TPN solution. The present invention enables to practically use a TPN solution previously containing a water-soluble vitamin B.

Abstract: A preparation comprising a fat emulsion of fat microparticles wherein said emulsion contains a stabilizer consisting essentially of a fatty acid, a basic amino acid and a saccharide is provided. In the preparation comprising a fat emulsion of fat microparticles of the present invention, said microparticles having a mean particle diameter of at most 100 nm are stable, and so the microparticles remain in blood without being uptaken by liver. Therefore in case of administering a pharmaceutical preparation prepared by using the above-mentioned preparation of the present invention, the pharmacological activity may be expressed at a desired site. Thus the preparation is extremely useful as a drug carrier for drug delivery system.

Abstract: A parenteral alimentation solution having excellent nutritional properties with preventing problems such as browning which comprises three components of a reducing sugar, amino acids and electrolytes in a specific composition and a specific amount.

Abstract: A pharmaceutical composition is prepared by the steps of dispersing a phospholipid uniformly in water to give an aqueous phospholipid dispersion, adding a medicament to the aqueous dispersion, freezing the thus-obtained aqueous dispersion, thereby entrapping the medicament in the lipid spherules, and then thawing the frozen dispersion to give an aqueous suspension of the medicament entrapped in the lipid spherules having a diameter of less than 5.0 .mu.. The pharmaceutical composition prepared above is used as a controlled release pharmaceutical preparation.