Abstract: The present invention provides methods for increasing expression of ICOS on an effector T cell comprising contacting said effector T cell with an anti-PD-1 antibody. The present invention also provides methods for decreasing expression of ICOS on a regulatory T cell comprising contacting said regulatory T cell with an anti-PD-1 antibody. The present invention provides methods for increasing sensitivity to an agent directed to ICOS in a human comprising administering to the human an anti-PD1 antibody. The present invention also provides methods of treating cancer in a human in need thereof comprising administering an anti-PD-1 antibody and an anti-ICOS antibody to said human, wherein the anti-PD-1 antibody increases T cell sensitivity to the ICOS antibody.

Abstract: The present invention provides methods for increasing expression of ICOS on an effector T cell comprising contacting said effector T cell with an anti-PD-1 antibody. The present invention also provides methods for decreasing expression of ICOS on a regulatory T cell comprising contacting said regulatory T cell with an anti-PD-1 antibody. The present invention provides methods for increasing sensitivity to an agent directed to ICOS in a human comprising administering to the human an anti-PD1 antibody. The present invention also provides methods of treating cancer in a human in need thereof comprising administering an anti-PD-1 antibody and an anti-ICOS antibody to said human, wherein the anti-PD-1 antibody increases T cell sensitivity to the ICOS antibody.

Abstract: A user device collects data corresponding to a plurality of communication options used by the user device to communicate with a contact. The data includes for each communication option, a time of last successful communication between the user device and the contact via the communication option. The communication options may include voice-mode communication options such as telephone numbers, and data-mode communication options such as e-mail addresses, instant messaging identifications, and social media identifications. In response to a failed attempt to communicate with the contact, the user device presents the plurality of communication options in a presentation through an interface of the user device. The presentation lists each of the plurality of communication options based on a probability of establishing a successful communication with the contact for each of the plurality of communication options.

Abstract: Methods and devices may select a particular radio access technology (RATs) available on a multi-technology wireless communication device to support a user activity based on monitored device usage patterns and power consumption profiles of the various RATs. Various embodiments may enable multi-RAT wireless communication devices to monitor the usage patterns of each service (i.e., wireless communication link) provided by the device, and estimate the power consumption during the user activity based on the power needs of services and the user activity. A multi-RAT wireless communication device may determine whether switching, enabling, or disabling services and/or RATs would reduce power consumption. Thus, the wireless communication device may extend the time that a user can perform a user activity when battery reserves are low by switching to a lower-power RAT and/or disabling power-hungry services.

Abstract: The present application relates to service management at a user equipment (UE). The described aspects include determining whether at least one activated service satisfies a termination condition based on detecting that a service deactivation triggering condition has been met. The described aspects further include determining whether the at least one activated service was activated based on an indication received from an interface unit of the UE based on determining that the at least one activated services satisfies the termination condition. Additionally, the described aspects include terminating operation of the at least one activated service based on determining that the at least one activated service satisfies the termination condition and the at least one service was not activated by the interface unit between the application and the at least one activated service.

Abstract: Methods and devices may select a particular radio access technology (RATs) available on a multi-technology wireless communication device to support a user activity based on monitored device usage patterns and power consumption profiles of the various RATs. Various embodiments may enable multi-RAT wireless communication devices to monitor the usage patterns of each service (i.e., wireless communication link) provided by the device, and estimate the power consumption during the user activity based on the power needs of services and the user activity. A multi-RAT wireless communication device may determine whether switching, enabling, or disabling services and/or RATs would reduce power consumption. Thus, the wireless communication device may extend the time that a user can perform a user activity when battery reserves are low by switching to a lower-power RAT and/or disabling power-hungry services.

Abstract: Systems and methods are described herein for performing thermal mitigation in a mobile communication device having a first subscription and a second subscription. The method includes, but not limited to, determining whether the mobile communication device has reached a first thermal level in which only circuit switching services are available, detecting that the second subscription is out of service in response to determining that the mobile communication device has reached the first thermal level, determining whether a current temperature exceeds, beyond a threshold, a temperature at a time of a previous scan for an available network for the second subscription, and waiting a first period of time before scanning for the available network for the second subscription, in response to determining that the current temperature exceeds, beyond the threshold, the temperature at the time of the previous scan.

Abstract: A user device collects data corresponding to a plurality of communication options used by the user device to communicate with a contact. The data includes for each communication option, a time of last successful communication between the user device and the contact via the communication option. The communication options may include voice-mode communication options such as telephone numbers, and data-mode communication options such as e-mail addresses, instant messaging identifications, and social media identifications. In response to a failed attempt to communicate with the contact, the user device presents the plurality of communication options in a presentation through an interface of the user device. The presentation lists each of the plurality of communication options based on a probability of establishing a successful communication with the contact for each of the plurality of communication options.

Abstract: A method and system for acknowledging multiple frames in a communication network is provided. A receiver detects transmission of frames from a transmitter. The receiver determines a format for an acknowledgment frame comprising multiple bytes, from multiple frame acknowledgment formats for reporting status of reception of the frames by the receiver. The receiver reports the status of reception of the frames by encoding a distance between a number of frames between two successive correctly received frames, between two successive unsuccessfully received frames, between a correctly received frame and a successive unsuccessfully received frame, or between an unsuccessfully received frame and a successive correctly received frame, in the acknowledgment frame. One or more of the frame acknowledgment formats are configured to generate the acknowledgment frame for acknowledging the frames using a decreased number of bytes.

Abstract: A method and system for acknowledging multiple frames in a communication network is provided. A receiver detects transmission of frames from a transmitter. The receiver determines a format for an acknowledgment frame comprising multiple bytes, from multiple frame acknowledgment formats for reporting status of reception of the frames by the receiver. The receiver reports the status of reception of the frames by encoding a distance between a number of frames between two successive correctly received frames, between two successive unsuccessfully received frames, between a correctly received frame and a successive unsuccessfully received frame, or between an unsuccessfully received frame and a successive correctly received frame, in the acknowledgment frame. One or more of the frame acknowledgment formats are configured to generate the acknowledgment frame for acknowledging the frames using a decreased number of bytes.

Abstract: An integrated diagnosis and prognosis system that collects vehicle information over the life of a vehicle and its development. The system provides the collected vehicle information to supplier management, product development management, service/dealership management, customer relations departments and production facilities, which use the information to take certain action for existing vehicles, fleets of vehicles or future vehicles to improve vehicle reliability and quality.

Abstract: A system and method for enhancing vehicle diagnostic and prognostic algorithms and improving vehicle maintenance practices. The method includes collecting data from vehicle components, sub-systems and systems, and storing the collected data in a database. The collected and stored data can be from multiple sources for similar vehicles or similar components and can include various types of trouble codes and labor codes as well as other information, such as operational data and physics of failure data, which are fused together. The method generates classes for different vehicle components, sub-systems and systems, and builds feature extractors for each class using data mining techniques of the data stored in the database. The method also generates classifiers that classify the features for each class. The feature extractors and feature classifiers are used to determine when a fault condition has occurred for a vehicle component, sub-system or system.

Abstract: A method for temporal trend detection employing non-parametric techniques. A set of discrete data is provided and a rank is assigned to the data based on both sensitivity and severity of the data. The method statistically ranks the ranked data by categorizing the data in bins defined by an average positional ranking that identifies the severity of the data for each sensitivity category provided by a bin. The method then clusters the statistically ranked data that has been categorized by average positional ranking so as to detect changes in the data. Clustering the statistically ranked data can include using a multi-nominal hypothesis testing procedure. The method then identifies trends in the data based on the detected changes.

Abstract: A system and method for enhancing vehicle diagnostic and prognostic algorithms and improving vehicle maintenance practices. The method includes collecting data from vehicle components, sub-systems and systems, and storing the collected data in a database. The collected and stored data can be from multiple sources for similar vehicles or similar components and can include various types of trouble codes and labor codes as well as other information, such as operational data and physics of failure data, which are fused together. The method generates classes for different vehicle components, sub-systems and systems, and builds feature extractors for each class using data mining techniques of the data stored in the database. The method also generates classifiers that classify the features for each class. The feature extractors and feature classifiers are used to determine when a fault condition has occurred for a vehicle component, sub-system or system.

Abstract: An integrated diagnosis and prognosis system that collects vehicle information over the life of a vehicle and its development. The system provides the collected vehicle information to supplier management, product development management, service/dealership management, customer relations departments and production facilities, which use the information to take certain action for existing vehicles, fleets of vehicles or future vehicles to improve vehicle reliability and quality.

Abstract: A piezo-noise microscope for use in examining a sample of piezoelectric material is provided. The piezo-noise microscope improves on existing atomic force microscope (AFM) techniques by generating piezoresponse noise signals which are useful for determining the long-term polarization stability of piezoelectric materials, and in particular ferroelectric materials, without the need to make repeated observations over extended periods of time. A method for detecting piezo-response noise in a sample of piezoelectric material using a piezo-noise microscope, and a method for detecting the stability of polarization in regions of a sample of piezoelectric material, are also provided.

Abstract: A scanning AC hall microscope and a method which measures the domain pattern of magnetic materials, such as magnetic storage media, by measuring the oscillatory motion of a domain boundary under the influence of an external applied AC magnetic field, which allows a differentiation between domains which are immobile and domains which are mobile.

Abstract: A method for reducing imprint in a ferroelectric device which includes the steps of: applying a signal having a bipolar pulse shape for a predetermined time to the ferroelectric device; and decreasing the signal amplitude gradually in predetermined intervals of time and amplitude. Preferably, the bipolar shape signal is a sinusoidal wave, a square wave, or a sawtooth wave and the ferroelectric device is a capacitor of a memory cell in a computer. Also provided is an apparatus for reducing imprint in a ferroelectric device.

Abstract: A method for reducing imprint in a ferroelectric device which includes the steps of: applying a signal having a bipolar pulse shape for a predetermined time to the ferroelectric device; and decreasing the signal amplitude gradually in predetermined intervals of time and amplitude. Preferably, the bipolar shape signal is a sinusoidal wave, a square wave, or a sawtooth wave and the ferroelectric device is a capacitor or a memory cell in a computer. Also provided is an apparatus for reducing imprint in a ferroelectric device.

Abstract: The present invention is directed, inter alia, to a switch comprising: (A) a superconducting material whose field cooled and zero field cooled ac permittivities differ from each other, and whose field cooled and zero field cooled ac susceptibilities differ from each other, in a range of temperature below the superconducting transition temperature of the material; (B) means for applying a static magnetic field to said material; (C) means for controllably applying to said material an oscillating magnetic field of a magnitude effective to convert said material from a state exhibiting filed cooled permittivity to a state exhibiting zero field cooled permittivity; and (D) means for applying to said material a heat pulse effective to convert said material from a state exhibiting zero field cooled permittivity to a state exhibiting field cooled permittivity, said switch operating between a superconducting zero field cooled state and a superconducting field cooled state.