Patents by Inventor Sachdev Sidhu

Sachdev Sidhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10214570
    Abstract: The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: February 26, 2019
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Sachdev Sidhu, Linda Beatty, Andreas Ernst
  • Publication number: 20190040144
    Abstract: The present disclosure is directed to novel FZD5-binding agents and methods and uses thereof for treating a disease or disorder associated with aberrant expression or activity of Frizzled protein.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 7, 2019
    Inventors: Guohua Pan, Jason Moffat, Sachdev Sidhu, Stephane Angers, Zachary Steinhart, Xiaowei Wang
  • Publication number: 20190010196
    Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
    Type: Application
    Filed: January 31, 2017
    Publication date: January 10, 2019
    Inventors: Daniel Durocher, Sachdev Sidhu, Wei Zhang, Frank Sicheri, Marella Canny
  • Patent number: 10081669
    Abstract: The present invention addresses a need for improved treatments for Filovirus infections.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: September 25, 2018
    Assignees: Albert Einstein College of Medicine, Inc., The Governing Council of the University of Toronto, The United States of America as Represented by the Secretary of the Army
    Inventors: Jonathan R. Lai, Jayne F. Koelhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Jr., Samantha Zak
  • Patent number: 10077304
    Abstract: This invention provides monoclonal antibodies that recognize one or more Frizzled receptors. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: September 18, 2018
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Sachdev Sidhu, Amandeep Gakhal, Guohua Pan, Jason Moffat, Melanie Robitaille, Stephane Angers
  • Publication number: 20180251532
    Abstract: Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death.
    Type: Application
    Filed: August 25, 2016
    Publication date: September 6, 2018
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Evripidis Gavathiotis, Jonathan R. Lai, Sachdev Sidhu
  • Publication number: 20170321205
    Abstract: The invention provides ubiquitin variants that specifically bind to SCF E3 ligases, and use of these variants to modulate the activity of SCF E3 ligases.
    Type: Application
    Filed: February 17, 2017
    Publication date: November 9, 2017
    Inventors: Maryna GORELIK, Sachdev SIDHU
  • Publication number: 20170275341
    Abstract: The invention provides ubiquitin variants that specifically bind to HECT E3 ligases, and methods of using these variants to modulate the activity of HECT E3 ligases.
    Type: Application
    Filed: February 17, 2017
    Publication date: September 28, 2017
    Inventors: Wei ZHANG, Sachdev SIDHU
  • Publication number: 20170204166
    Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.
    Type: Application
    Filed: August 6, 2015
    Publication date: July 20, 2017
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND
    Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
  • Publication number: 20170184608
    Abstract: There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.
    Type: Application
    Filed: November 7, 2016
    Publication date: June 29, 2017
    Inventors: Sachdev Sidhu, Jason Moffat, Helena Persson, Nish Patel, Saravanan Sundararajan, Amandeep Gakhal, Wei Ye, Jelena Tomic, Megan Elizabeth Mclaughlin
  • Publication number: 20170088606
    Abstract: The present invention addresses a need for improved treatments for Filovirus infections.
    Type: Application
    Filed: May 23, 2016
    Publication date: March 30, 2017
    Applicant: Albert Einstein College of Medicine, Inc.
    Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, JR., Samantha Zak
  • Publication number: 20160194394
    Abstract: This invention provides monoclonal antibodies that recognize one or more Frizzled receptors. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
    Type: Application
    Filed: August 14, 2014
    Publication date: July 7, 2016
    Inventors: Sachdev Sidhu, Amandeep Gakhal, Guohua Pan, Jason Moffat, Melanie Robitaille, Stephane Angers
  • Patent number: 9346875
    Abstract: The present invention addresses a need for improved treatments for filovirus infections.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: May 24, 2016
    Assignees: Albert Einstein College of Medicine, Inc., The Governing Council of the University of Toronto, The United States of America as Represented by the Secretary of the Army
    Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Jr., Samantha Zak
  • Publication number: 20140356354
    Abstract: The present invention addresses a need for improved treatments for filovirus infections.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, University of Toronto, Government of the United States
    Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, JR., Samantha Zak
  • Publication number: 20140242095
    Abstract: The invention relates to modulating the SIRP?—CD47 interaction in order to treat hematological cancer and compounds therefor. In particular, there is also provided SIRP? antibodies and antibody fragments, preferably used for treating hematological cancer.
    Type: Application
    Filed: October 19, 2012
    Publication date: August 28, 2014
    Applicant: University Health Network
    Inventors: Jean C. Y. Wang, Jayne S. Danska, John Dick, Sachdev Sidhu, Maruti Uppalapati
  • Publication number: 20130244883
    Abstract: There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.
    Type: Application
    Filed: September 27, 2012
    Publication date: September 19, 2013
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Sachdev Sidhu, Jason Moffat, Helena Persson, Nish Patel, Saravanan Sundararajan, Amandeep Gakhal, Wei Ye
  • Publication number: 20130225436
    Abstract: The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
    Type: Application
    Filed: June 8, 2011
    Publication date: August 29, 2013
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Sachdev Sidhu, Linda Beatty, Andreas Ernst
  • Patent number: 7785903
    Abstract: The invention provides polypeptides comprising a variant heavy chain variable framework domain (VFR). In some embodiments, the amino acids defining the VFR form a loop of an antigen binding pocket. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR. The polypeptide may optionally comprise one or more complementary determining regions (CDRs) of antibody variable domains. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR and one or more variant CDRs. Libraries of polypeptides that include a plurality of different antibody variable domains generated by creating diversity in a VFR, and optionally, one or more CDRs are provided and may be used as a source for identifying novel antigen binding polypeptides that can be used therapeutically or as reagents. The invention also provides fusion polypeptides, compositions, and methods for generating and using the polypeptides and libraries.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: August 31, 2010
    Assignee: Genentech, Inc.
    Inventors: Christopher J. Bond, Sachdev Sidhu
  • Publication number: 20090023602
    Abstract: The invention provides variant CDRs comprising highly restricted amino acid sequence diversity. These polypeptides provide a flexible and simple source of sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
    Type: Application
    Filed: January 16, 2008
    Publication date: January 22, 2009
    Applicant: Genentech, Inc.
    Inventors: Frederic Fellouse, Sachdev Sidhu
  • Publication number: 20070292936
    Abstract: The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.
    Type: Application
    Filed: May 8, 2007
    Publication date: December 20, 2007
    Applicant: Genentech, Inc.
    Inventors: Pierre Barthelemy, Sachdev Sidhu