Patents by Inventor Sachet Shukla

Sachet Shukla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SHARED NEOANTIGENS
    Publication number: 20200368337
    Abstract: Disclosed herein in one aspect is a pharmaceutical composition comprising a plurality of neoantigenic peptides and a pharmaceutically acceptable carrier, each neoantigenic peptide comprising a tumor-specific neoepitope capable of binding to an HLA protein in a subject, each tumor-specific neoepitope comprising a tumor-specific mutation present in a tumor, wherein (a) the composition comprises neoantigenic peptides comprising tumor-specific mutations present in at least 1% of subjects in a population of subjects suffering from cancer; (b) the composition comprises neoantigenic peptides comprising tumor-specific neoepitopes which bind to HLA proteins present in at least 5% of subjects in the population; and (c) the composition comprises at least one neoantigenic peptide capable of eliciting an immune response against a tumor present in at least 5% of the subjects in the population of subjects suffering from cancer.
    Type: Application
    Filed: April 27, 2020
    Publication date: November 26, 2020
    Inventors: Edward F. Fritsch, Nir Hacohen, Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Pavan Bachireddy, Jing Sun
  • COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE AND RESISTANCE TO CTLA4 BLOCKADE IN MELANOMA USING A GENE EXPRESSION SIGNATURE
    Publication number: 20190300967
    Abstract: The present invention relates to compositions and methods for predicting response and resistance to CTA4 blockade in melanoma.
    Type: Application
    Filed: October 13, 2017
    Publication date: October 3, 2019
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Pavan Bachireddy, Sachet A. Shukla, Catherine J. Wu
  • Methods and compositions for elucidating protein expression profiles in cells
    Publication number: 20060134629
    Abstract: The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.
    Type: Application
    Filed: September 12, 2003
    Publication date: June 22, 2006
    Inventors: Charles Link, Tatiana Seregina, Nicholas Vahanian, James Higginbotham, William Ramsey, Bradley Powers, Sachet Shukla, Won Young, Teresa Dicolandrea, Mario Mautino
  • Methods and compositions for elucidating relative protein expression levels in cells
    Patent number: 6897020
    Abstract: The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: May 24, 2005
    Assignee: NewLink Genetics Inc.
    Inventors: Charles J. Link, Tatiana Seregina, Nicholas N. Vahanian, James N. Higginbotham, W. Jay Ramsey, Bradley J. Powers, Sachet A. Shukla, Won Bin Young
  • Methods and compositions for elucidating relative protein expression levels in cells
    Patent number: 6753142
    Abstract: The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: June 22, 2004
    Assignee: NewLink Genetics Inc.
    Inventors: Charles J. Link, Tatiana Seregina, Nicholas N. Vahanian, James N. Higginbotham, W. Jay Ramsey, Bradley J. Powers, Sachet A. Shukla, Won Bin Young