Abstract: A patch preparation having a backing layer and a drug layer laminated on the backing layer; wherein the drug layer contains an adhesive containing at least one compound selected from the group consisting of fentanyl and pharmaceutically acceptable salts thereof, polyisobutylene, and a silicon-containing polymer; and a mass ratio of the polyisobutylene and the silicon-containing polymer in the adhesive is 20:1 to 7:3.

Abstract: A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.

Abstract: A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.

Abstract: A pressure-sensitive adhesive base which contains the liquid organic ingredient and which, despite this, has moderate pressure-sensitive adhesion properties (tackiness and cohesive force) and causes no bleeding. It hardly injures the keratin of the skin and is inhibited from irritating the skin. The pressure-sensitive adhesive base comprises the following ingredients (A) to (C): (A) a copolymer comprising units of a monomer containing a carboxy group and units of a (meth) acrylic ester; (B) one or more, liquid or semisolid organic compounds which are compatible with the copolymer of the ingredient (A); and (C) at least one member selected among polyvalent-metal oxides and polyvalent-metal hydroxides, the total content of the ingredient (C) being 0.001-5 mass % based on the whole pressure-sensitive adhesive base. The adhesive base contains substantially no water.

Abstract: A patch preparation having a backing layer and a drug layer laminated on the backing layer; wherein the drug layer contains an adhesive containing at least one compound selected from the group consisting of fentanyl and pharmaceutically acceptable salts thereof, polyisobutylene, and a silicon-containing polymer; and a mass ratio of the polyisobutylene and the silicon-containing polymer in the adhesive is 20:1 to 7:3.

Abstract: A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.

Abstract: A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.

Abstract: An object of the present invention is to provide a patch-containing packaging pouch which enables stable storage of a patch containing bisoprolol in a pressure-sensitive adhesive layer. A packaged desiccant 1 of the present invention has a packaging pouch 8 composed of a pair of laminated package members 7a and 7b arranged in mutual opposition, and a patch 10 housed in the space within this packaging pouch 8. Patch 10 is provided with a support 12 and a pressure-sensitive adhesive layer 14 laminated substantially over the entire surface of one side of this support 12. In addition, the pressure-sensitive adhesive layer is composed of a pressure-sensitive adhesive composition containing a pressure-sensitive adhesive and bisoprolol or pharmaceutically acceptable salt thereof. Moreover, a packaged desiccant 20 is housed within packaging pouch 8. The relative humidity within packaging pouch 8 is maintained at 25% or less in a patch-containing packaging pouch 1 having this constitution.

Abstract: The patch-containing pouch 100 of the present invention is a pouch 1 housing in its interior a patch 2 which has a pressure-sensitive adhesive layer 22 laminated on at least one side of a support 21 and has a release film 23 attached to the pressure-sensitive adhesive layer 22, wherein the pressure-sensitive adhesive layer 22 contains a drug represented by general formula (1) or a pharmaceutically acceptable salt thereof, and at least a portion of the inner surface 31a or 31b of the pouch 1 in contact with the patch 2 is made of polyacrylonitrile. [where R represents 2-isopropoxyethoxymethyl, carbamoylmethyl or 2-methoxyethyl.

Abstract: An adhesive patch which includes a pressure-sensitive adhesive layer comprising a composition which comprises: bisoprolol and/or a pharmaceutically acceptable salt thereof; and an acrylic polymer obtained by copolymerizing a (meth)acrylic ester with a carboxylated (meth)acrylic acid. The adhesive patch is stable and excellent in penetration through the skin.

Abstract: The present invention is a pressure sensitive adhesive comprising: an ingredient (A) which is a copolymer of a carboxyl group-containing monomer and (meth)acrylic ester; and an ingredient (B) which is a copolymer of a pyrrolidone group-containing monomer and (meth)acrylic ester, wherein the ingredient (A) is crosslinked by at least one crosslinking agent selected from the group consisting of a metal chelate compound, a metal oxide and a metal hydroxide, and the blending ratio of the ingredient (A) is 70 to 90 weight % based on the total amount of the ingredient (A) and ingredient (B).