Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.

Abstract: A cutting tool includes a substrate and a coating film that is disposed on the substrate, wherein the coating film includes a first layer composed of metal tungsten and hexagonal ditungsten carbide, and the first layer has an elastic deformation rate of 43.0 or more and 58.0 or less.

Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.

Abstract: The present invention provides a novel compound having an excellent ?-lactamase inhibitory effect. The present invention provides: a compound which has an excellent ?-lactamase inhibitory effect, and is represented by formula (1a), (1b) or (11); or a pharmaceutically acceptable salt thereof. This compound provides a prophylactic or therapeutic agent effective for bacterial infections when used in combination with ?-lactam-based drugs or used as a single agent. The present invention also provides a prophylactic or therapeutic agent effective for treating various diseases, by being used in combination with ?-lactam-based drugs.

Abstract: A surface-coated cutting tool includes a substrate and a coating film that coats the substrate, wherein the coating film includes a WC1-x layer composed of a compound represented by WC1-x, where x is more than or equal to 0.54 and less than or equal to 0.58, and the compound represented by WC1-x includes a hexagonal crystal structure.

Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.

Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.

Abstract: A surface-coated cutting tool includes a substrate and a coating film that coats the substrate, wherein the coating film includes a WC1-x layer composed of a compound represented by WC1-x, where x is more than or equal to 0.54 and less than or equal to 0.58, the compound represented by WC1-x includes a hexagonal crystal structure, and a ratio 1(110)/1(011) of an X-ray diffraction intensity of a (110) plane to an X-ray diffraction intensity of a (011) plane in the WC1-x layer is more than or equal to 0.1 and less than or equal to 0.4.

Abstract: A surface-coated cutting tool includes a substrate and a coating film that coats the substrate, wherein the coating film includes a WC1-x layer composed of a compound represented by WC1-x, where x is more than or equal to 0.54 and less than or equal to 0.58, the compound represented by WC1-x includes a hexagonal crystal structure, and a maximum point of a peak exists in a range of 31.2 to 31.4 eV in a spectrum diagram of a 4f orbital of a tungsten element obtained when measuring the WC1-x layer by an X-ray photoelectron spectroscopy analysis method.

Abstract: A surface-coated cutting tool includes a substrate and a coating film that coats the substrate, wherein the coating film includes a WC1-x layer composed of a compound represented by WC1-x, where x is more than or equal to 0.54 and less than or equal to 0.58, and the compound represented by WC1-x includes a hexagonal crystal structure.

Abstract: Provided is a surface-coated cutting tool combining superior heat resistance, superior wear resistance, and superior lubricity with high adhesion between a substrate and a coating. A surface-coated cutting tool of the present invention includes a substrate and a coating formed on the substrate, and the coating is characterized in that the coating is formed by physical vapor deposition and includes one or more layers, that at least one of the one or more layers is a first coating layer, that the first coating layer contains aluminum and nitrogen, has a thermal effusivity of 2,000 to 5,000J·sec?1/2·m?2·K?1, and has a thickness of 0.2 to 5?m, that the first coating layer includes an amorphous region and a crystalline region in order from the substrate side, that the amorphous region is amorphous and has a thickness of 0.01 to 2?m, and that the crystalline region has a crystal structure including a hexagonal structure.

Abstract: Provided is a surface-coated cutting tool combining superior heat resistance, superior wear resistance, and superior lubricity. A surface-coated cutting tool of the present invention includes a substrate and a coating formed on the substrate, and the coating is characterized in that the coating is formed by physical vapor deposition and includes one or more layers, that at least one of the one or more layers is a first coating layer, and that the first coating layer contains aluminum and nitrogen, has a thermal effusivity of 2,000 to 5,000 J·sec?1/2·m?2·K?1, has a thickness of 0.2 to 5 ?m, and has a crystal structure including a hexagonal structure.

Abstract: A surface-coated cutting tool of the present invention includes a substrate and a coated layer formed on the substrate, and the coated layer is a physical-vapor-deposition layer having a thickness of 10 ?m or more. A surface region having a thickness of 1 ?m from a surface of the coated layer includes a first region whose integrated residual stress is a compressive stress and a second region whose integrated residual stress is a tensile stress, and the integrated residual stress of the surface region falls within the range of ?1.5 to 1.5 GPa in any region included in the surface region.

Abstract: Provided is a surface-coated cutting tool combining superior heat resistance, superior wear resistance, and superior lubricity. A surface-coated cutting tool of the present invention includes a substrate and a coating formed on the substrate, and the coating is characterized in that the coating is formed by physical vapor deposition and includes one or more layers, that at least one of the one or more layers is a first coating layer, and that the first coating layer contains aluminum and nitrogen, has a thermal effusivity of 2,000 to 5,000 J·sec?1/2·m?2·K?1, has a thickness of 0.2 to 5 ?m, and has a crystal structure including a hexagonal structure.

Abstract: Provided is a surface-coated cutting tool combining superior heat resistance, superior wear resistance, and superior lubricity with high adhesion between a substrate and a coating. A surface-coated cutting tool of the present invention includes a substrate and a coating formed on the substrate, and the coating is characterized in that the coating is formed by physical vapor deposition and includes one or more layers, that at least one of the one or more layers is a first coating layer, that the first coating layer contains aluminum and nitrogen, has a thermal effusivity of 2,000 to 5,000 J·sec?1·m?1·K?1, and has a thickness of 0.2 to 5 ?m, that the first coating layer includes an amorphous region and a crystalline region in order from the substrate side, that the amorphous region is amorphous and has a thickness of 0.01 to 2 ?m, and that the crystalline region has a crystal structure including a hexagonal structure.

Abstract: A surface-coated cutting tool according to the present invention includes a base material and a coating film formed on the base material. The coating film includes one or more hard layer and one or more oxygen-rich hard layer. The hard layer is crystalline in its entirety or crystalline with a part thereof being amorphous. The oxygen-rich hard layer and the hard layer are stacked and the oxygen-rich hard layer is amorphous in a region of interface with the hard layer.

Abstract: A surface-coated cutting tool of the present invention includes a substrate and a coated layer formed on the substrate, and the coated layer is a physical-vapor-deposition layer having a thickness of 10 ?m or more. A surface region having a thickness of 1 ?m from a surface of the coated layer includes a first region whose integrated residual stress is a compressive stress and a second region whose integrated residual stress is a tensile stress, and the integrated residual stress of the surface region falls within the range of ?1.5 to 1.5 GPa in any region included in the surface region.

Abstract: A surface-coated cutting tool according to the present invention includes a base material and a coating film formed on the base material. The coating film includes one or more hard layer and one or more oxygen-rich hard layer. The hard layer is crystalline in its entirety or crystalline with a part thereof being amorphous. The oxygen-rich hard layer and the hard layer are stacked and the oxygen-rich hard layer is amorphous in a region of interface with the hard layer.