Patents by Inventor Sachin Bhuta

Sachin Bhuta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing silodosin
    Patent number: 9938239
    Abstract: The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step, in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center, R1 is a protecting group, and R2 is cyano or carbamoyl, are separated.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 10, 2018
    Assignee: Sandoz AG
    Inventors: Parven Kumar Luthra, Sachin Bhuta, Chandrakant Abhinay, N. Chaven Dattatraya, D. Metkar Shashikant
  • Method For Preparing Silodosin
    Publication number: 20160176818
    Abstract: The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step, in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center, R1 is a protecting group, and R2 is cyano or carbamoyl, are separated.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 23, 2016
    Applicant: Sandoz AG
    Inventors: Parven Kumar Luthra, Sachin Bhuta, Chandrakant Abhinay, N. Chaven Dattatraya, D. Metkar Shashikant
  • Purification of posaconazole and of posaconazole intermediates
    Patent number: 9206146
    Abstract: The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or Cl, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HCl comprised in a second suitable solvent to obtain the HCl salt of the compound of formula (I).
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: December 8, 2015
    Assignee: SANDOZ AG
    Inventors: Martin Langner, Dominic De Souza, Abhinay C. Pise, Sachin Bhuta
  • Preparation of posaconazole intermediates
    Patent number: 9073904
    Abstract: The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1 and Y2 are independently F or Cl, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: July 7, 2015
    Assignee: SANDOZ AG
    Inventors: Dominic De Souza, Shreerang V. Joshi, Sachin Bhuta, Abhinay C. Pise, Dattatraya N. Chavan, Shashikant D. Metkar
  • METHOD FOR PREPARING SILODOSIN
    Publication number: 20150038727
    Abstract: The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step, in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center, R1 is a protecting group, and R2 is cyano or carbamoyl, are separated.
    Type: Application
    Filed: October 19, 2012
    Publication date: February 5, 2015
    Applicant: SANDOZ AG
    Inventors: Parven Kumar Luthra, Sachin Bhuta, Chandrakant Pise Abhinay, N. Chavan Dattatraya, D. Metkar Shashikant
  • PURIFICATION OF POSACONAZOLE AND OF POSACONAZOLE INTERMEDIATES
    Publication number: 20130211086
    Abstract: The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or Cl, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HCl comprised in a second suitable solvent to obtain the HCl salt of the compound of formula (I).
    Type: Application
    Filed: May 18, 2011
    Publication date: August 15, 2013
    Applicant: SANDOZ AG
    Inventors: Martin Langner, Dominic De Souza, Abhinay C. Pise, Sachin Bhuta
  • PREPARATION OF POSACONAZOLE INTERMEDIATES
    Publication number: 20130203994
    Abstract: The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1 and Y2 are independently F or Cl, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.
    Type: Application
    Filed: May 18, 2011
    Publication date: August 8, 2013
    Applicant: SANDOZ AG
    Inventors: Dominic De Souza, Shreerang V. Joshi, Sachin Bhuta, Abhinay C. Pise, Dattatraya N. Chavan, Shashikant D. Metkar
  • Process for the preparation of indoline derivatives and their intermediates thereof
    Patent number: 8471039
    Abstract: Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: June 25, 2013
    Assignee: Sandoz AG
    Inventors: Shreerang Joshi, Sachin Bhuta, Sanjay Talukdar, Sudhir Sawant, Deepak Venkataraman, Abhinay Pise, Shashikant Metkar, Dattatraya Chavan, Parven Kumar Luthra
  • PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20120253038
    Abstract: Efficient processes for the synthesis of pharmaceutically useful compounds such as (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate (Formula IX) using cyanomethoxybenzyl halides of Formula III, where X=Halogens e.g., Cl, F, Br, I; G=Any electron donating or electron withdrawing substituent.
    Type: Application
    Filed: April 9, 2010
    Publication date: October 4, 2012
    Applicant: SANDOZ AG
    Inventors: Shreerang Joshi, Sachin Bhuta, Sanjay Talukdar, Sudhir Sawant, Deepak Venkatraman
  • PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF
    Publication number: 20120165548
    Abstract: Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.
    Type: Application
    Filed: September 13, 2010
    Publication date: June 28, 2012
    Applicant: SANDOZ AG
    Inventors: Shreerang Joshi, Sachin Bhuta, Sanjay Talukdar, Sudhir Sawant, Deepak Venkataraman, Abhinay Pise, Shashikant Metkar, Dattatraya Chavan, Parven Kumar Luthra
  • PROCESS FOR THE PREPARATION OF S-CLOPIDOGREL
    Publication number: 20110190502
    Abstract: A process for the preparation of (S)-Clopidogrel free base or a pharmaceutically acceptable salt thereof by the racemization of the undesired (R)-Clopidogrel in the presence of a suitable base followed by resolution with camphor sulfonate salt and further treatment with an inorganic acid to yield the title compound.
    Type: Application
    Filed: October 23, 2009
    Publication date: August 4, 2011
    Applicant: SANDOZ AG
    Inventors: Shreerang Joshi, Sachin Bhuta, Raji Nair, Sanjukumar Salunke