Abstract: The present invention relates to a Si/Al zeolite catalyst with cubical morphology, having pore diameter in the range of 0.5 to 0.6 ?m, pore volume in the range of 0.2 to 0.3 cc/g, surface area in the range of 500 to 700 m2/g, and SiO2/Al2O3 ratio in the range of 30 to 200. The present invention also relates to a process for its preparation and its application in one step, one pot synthesis of ether.

Abstract: GHB drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least GHB drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the GHB drug entrapped therein for at least about 3 hours.

Abstract: GHB drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least GHB drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the GHB drug entrapped therein for at least about 3 hours.

Abstract: The present invention discloses novel method for synthesizing vegan cholesterol and vitamin D3 from inexpensive crude phytosterol.

Abstract: Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3?-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate ?-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provide. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours.

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours.

Abstract: The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.

Abstract: The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provide. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours.

Abstract: GHB drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least GHB drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the GHB drug entrapped therein for at least about 3 hours.

Abstract: Drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least one drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the drug entrapped therein for at least about 3 hours.

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

Abstract: A network management entity is configured to communicate with one or more network security devices. Each network security device is configured to store in a respective event queue an event for each attempt to access a network accessible destination through the security device. Each event indicates the destination of the attempted access. The management entity periodically collects from the event queues the stored events so that less that all of the events stored in the event queues over a given time period are collected. The management entity determines, based on the collected events, top destinations as the destinations that occur most frequently in the collected events. The management entity determines, based on the collected events, bottom destinations as the destinations that occur least frequently in the collected events. The management entity generates for display indications of the top destinations and generates for display indications of the bottom destinations.

Abstract: A management entity generates for display multiple icons, each icon representing an actor or a resource in a networking environment, and defines a generic security policy by receiving user input in the form of a line drawn between a first icon representing an actor and a second icon representing a resource to control abilities between the actor and the resource. The management entity translates the generic security policy to multiple native security policies each of which is based on a corresponding one of multiple native policy models associated with corresponding ones of multiple security devices, and supply data descriptive of the multiple native security policies to the corresponding ones of the security devices to configure the corresponding ones of the security devices to implement the native security policies.

Abstract: A method is provided in which a development environment sends commands to an on-premises device that are signed by both (a) development environment and by (b) an execution environment (trusted source), and account for versioning. In so doing, the on-premises device that receives the command is able to authenticate both the sending entity, i.e., a production server, and the source of the command files to determine that the command is a valid configuration/upgrade package that may be safely installed and executed.

Abstract: Presented herein are techniques for creating a policy block comprised of a group of lines of rules/statements across configuration files for network devices. An algorithm is provided that determines when multiple policies are to be merged together into one policy. In one embodiment, data is uploaded from a network that includes a plurality of network devices. The data represents policy rules configured on the plurality of network devices. The data representing the policy rules is compared for similarities in order to group together policy rules based on their similarities. Data is stored representing a plurality of clusters, each cluster representing a group of policy rules that have been grouped together. One or more configuration policies are generated to be applied across the plurality of network devices using the data representing each of the plurality of clusters, while maintaining context of policy rule processing.

Abstract: A management entity generates for display multiple icons, each icon representing an actor or a resource in a networking environment, and defines a generic security policy by receiving user input in the form of a line drawn between a first icon representing an actor and a second icon representing a resource to control abilities between the actor and the resource. The management entity translates the generic security policy to multiple native security policies each of which is based on a corresponding one of multiple native policy models associated with corresponding ones of multiple security devices, and supply data descriptive of the multiple native security policies to the corresponding ones of the security devices to configure the corresponding ones of the security devices to implement the native security policies.