Patents by Inventor Sachio Ishimoto

Sachio Ishimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4169150
    Abstract: Novel 4H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives of the formula ##STR1## wherein at least one of R.sub.1, R.sub.2 and R.sub.3 represent lower alkyl and the remainder hydrogen, R.sub.4 represents hydrogen or lower alkyl, ring A optionally contains at least one substituent selected from halogen, nitro and trifluoromethyl, and ring B optionally contains at least one substituent selected from halogen, nitro, trifluoromethyl, lower alkyl and lower alkoxy; and novel intermediates thereof expressed by the formula ##STR2## wherein Z represents protected amino. Compounds of formula (I) are prepared by subjecting compounds of formula (II) to protective group-elimination and cyclization. The compounds of formula (I) and acid addition salts thereof have useful anti-anxietic, sedative, anti-convulsant, muscle relaxant and hypnotic, and their toxicity is low.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: September 25, 1979
    Assignee: Teijin Limited
    Inventors: Takeshi Hara, Yasutaka Kayama, Kazuhiko Itoh, Toshiro Mori, Hitoshi Fujimori, Tamiko Sunami, Yoshinobu Hashimoto, Sachio Ishimoto
  • Patent number: 4139717
    Abstract: 1,3-Dicarbonyl compounds useful as medicines, agricultural chemicals, perfumes, and their intermediates are prepared by reacting a specific .alpha.,.beta.-unsaturated carbonyl compound with a specific organic copper lithium compound in the presence of an aprotic inert organic solvent, and then reacting the reaction product with an organic carboxylic acid halide or anhydride. In particular, novel 2-acyl-3-substituted cyclopentan-1-ones and 2-acyl-3-substituted cyclohexan-1-ones having important physiological activities are provided.
    Type: Grant
    Filed: January 4, 1977
    Date of Patent: February 13, 1979
    Assignee: Teijin Limited
    Inventors: Seizi Kurozumi, Takeshi Toru, Toshio Tanaka, Shuzi Miura, Makiko Kobayashi, Sachio Ishimoto
  • Patent number: 4138553
    Abstract: Novel substituted hydrazide derivatives of 7-(substituted)amino-3-methylene-cepham-4-carboxylic acids expressed by the formula ##STR1## wherein R.sub.1 represents alkyl containing at least 3 carbon atoms, cycloalkyl, or optionally substituted aryl, and one of R.sub.2 and R.sub.3 represents hydrogen with the other being hydrogen or the same as R.sub.1 ; or R.sub.1 and R.sub.2 form a heterocyclic ring optionally through a hetero atom together with the attached nitrogen and R.sub.3 represents hydrogen atom; and Z.sub.1 represents amino or protected amino; and acid addition salts thereof, which are useful as intermediates for synthesizing cephalosporin antibiotics.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: February 6, 1979
    Assignee: Teijin Limited
    Inventors: Sachio Ishimoto, Hisao Yamaguchi, Yoshinori Kato, Takeo Oba, Kenji Ozawa, Yataro Ichikawa, Koji Nakagawa, Hideki Tsuruta
  • Patent number: 4132726
    Abstract: Novel optically active compounds of 4-protected hydroxy-cyclopent-2-en-1-ones of the formula ##STR1## wherein R is a splittable protective group for an alcoholic hydroxyl group, and a process for preparing the 4-protected hydroxycyclopent-2-en-1-ones by oxidizing monohydroxy-protected derivatives of cyclopent-1-ene-3,5-diol expressed by the following formula ##STR2## wherein R is the same as defined above. Optically active 4-hydroxycyclopent-2-en-1-one which is an optically active isomer of the compound of formula (2); or optically active cyclopent-1-en-3,5-diol (R-isomer) and a novel diacyl derivative of the diol, a novel monoacylmonosilyl-derivative of the diol and a novel monoacylmonotetrahydropyranol-derivative of the diol, which are intermediates for the protective derivative of formula (1). Processes are also provided for preparing the protective derivatives of formula (1) by converting these intermediates by esterification, hydrolysis, enzymatic processes, etc.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: January 2, 1979
    Assignee: Teijin Limited
    Inventors: Seizi Kurozumi, Takeshi Toru, Toshio Tanaka, Shuzi Miura, Makiko Kobayashi, Sachio Ishimoto, Sadakazu Matsubara
  • Patent number: 4059571
    Abstract: Novel immunoglobulin derivatives which are characterized in that in which the interchain disulfide bonds of immunoglobulin are predominantly cleaved, on the average 3 to 5 of the interchain disulfide bonds or the inter- and intra-chain disulfide bonds being cleaved, and so produced sulfur atoms (S-) are S-sulfonated (--S-SO.sub.3). The above immunoglobulin derivatives are prepared by reacting native immunoglobulin withA. a compound capable of forming tetrathionate ion, andB. a compound capable of forming in water, sulfite ion whereby cleaving on the average 3 to 5 inter-chain disulfide bonds, or inter- and intra-chain disulfide bonds, of the native immunoglobulin, and S-sulfonating (S-SO.sub.3) the so formed sulfur atoms. This invention also provides a water-soluble composition for injection containing said immunoglobulin derivative having the titre of anti-diphtheria of at least 1.0 I.U./ml at its concentration of 10.
    Type: Grant
    Filed: March 4, 1975
    Date of Patent: November 22, 1977
    Assignee: Teijin Limited
    Inventors: Katsuhiko Tomibe, Yasuhiko Masuho, Kimihiko Matsuzawa, Sachio Ishimoto, Kazuo Satake, Tsuneo Watanabe
  • Patent number: 4039563
    Abstract: A process for preparing cyclopent-2-en-1-one derivatives of the formula ##STR1## wherein R.sub.1 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group, andR.sub.2 is a hydrogen atom or a substituent which is not substantially brominated under the treating conditions, which comprises treating a cyclopentanone derivative of the formula ##STR2## wherein R.sub.1 and R.sub.2 are the same as defined above, with pyridinium hydrobromide perbromide.
    Type: Grant
    Filed: April 28, 1975
    Date of Patent: August 2, 1977
    Assignee: Teijin Limited
    Inventors: Toshio Tanaka, Seizi Kurozumi, Takeshi Toru, Shuji Miura, Makiko Kobayashi, Sachio Ishimoto
  • Patent number: 4022891
    Abstract: Novel 1.alpha., 24-dihydroxycholecalciferol and derivatives thereof which are useful with reduced side-effects for the treatment of abnormal metabolism of calcium and phosphorus caused by liver failure, renal failure, gastrointestinal tract failure and parathyroid failure, and related bone diseases. Preparation of the novel 1.alpha., 24-dihydroxycholecalciferol and their derivatives starts from 1.alpha., 24-dihydroxycholesterol prepared by reacting 1.alpha., 2.alpha.-epoxy-24-keto-cholesta-4,6-dien-3-one with an alkali metal and a proton donor in the presence of liquid ammonia or a liquid amine. Reaction of the 1.alpha., 24-dihydroxycholesterol with an allylic brominating agent, followed by contacting with a dehydrobrominating agent, affords 1.alpha.,3.beta., 24-trihydroxycholesta-5,7-diene derivative, which can then be converted to 1.alpha., 24-dihydroxycholocalciferol by ultraviolet irradiation in a organic solvent, followed by isomerization. Processes are also provided for separating 1.alpha.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: May 10, 1977
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Yoshinobu Hashimoto, Hiroyuki Kawashima, Sachio Ishimoto, Nobuo Ikekawa, Masuo Morisaki
  • Patent number: 4009196
    Abstract: 1,3-Dicarbonyl compounds useful as medicines, agricultural chemicals, perfumes, and their intermediates are prepared by reacting a specific .alpha.,.beta.-unsaturated carbonyl compound with a specific organic copper lithium compound in the presence of an aprotic inert organic solvent, and then reacting the reaction product with an organic carboxylic acid halide or anhydride. In particular, novel 2-acyl-3-substituted cyclopentan-1-ones and 2-acyl-3-substituted cyclohexan-1-ones having important physiological activities are provided.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: February 22, 1977
    Assignee: Teijin Limited
    Inventors: Seizi Kurozumi, Takeshi Toru, Toshio Tanaka, Shuzi Miura, Makiko Kobayashi, Sachio Ishimoto
  • Patent number: 4008125
    Abstract: New optically active cyclopentene-diol and the mono- or diacyl esters thereof and a process for converting a diacyl ester of cyclopent-1-en-3,5-diol to its monoacyl ester and/or its diol which comprises subjecting a diacyl ester of cyclopent-1-en-3,5-diol containing at least one of the optically active or inactive diacyl ester of trans-cyclopent-1-en-3,5-diol (trans-isomer) and diacyl esters of cis-cyclopent-1-en-3,5-diol (cis-isomer), to the action of a microorganism or enzyme having at least a selectivity in its rates of hydrolyzing the acyloxy group (R) configuration and the acyloxy group (S) configuration of said diacyl ester. These new compounds are valuable as starting materials for the preparation of prostaglandin or its analogues.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: February 15, 1977
    Assignee: Teijin Limited
    Inventors: Seizi Kurozumi, Takeshi Toru, Toshio Tanaka, Shuzi Miura, Makiko Kobayashi, Sadakazu Matsubara, Sachio Ishimoto
  • Patent number: 4001308
    Abstract: A process for the preparation of 1,4-diacetoxycyclopent-2-ene, which comprises contacting a solution of 1,4-dibromocyclopent-2-ene in an inert organic solvent which is slightly soluble or insoluble in water, with an aqueous solution or suspension of at least one metal salt of acetic acid which is at least partially water-soluble, in the presence of a cationic surface-active compound.
    Type: Grant
    Filed: December 13, 1974
    Date of Patent: January 4, 1977
    Assignee: Teijin Limited
    Inventors: Seizi Kurozumi, Takeshi Toru, Toshio Tanaka, Shuzi Miura, Makiko Kobayashi, Sachio Ishimoto
  • Patent number: 3936478
    Abstract: A process for the preparation of desmosterol of which the hydroxyl group at the 3-position is protected, or bis-form derivatives thereof in high purity and with high yields, which comprises reacting 24-hydroxycholesterol of which the hydroxyl group at the 3-position is protected, or bis-form derivatives thereof, withA. phosphorus pentoxide or acid potassium sulfate, orB. phosphorus oxychloride, thionyl chloride, or sulfonyl chlorides, in the presence of tertiary amine.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: February 3, 1976
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Sachio Ishimoto