Patents by Inventor Sadafumi Omura
Sadafumi Omura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5474923Abstract: A method for introducing hydroxyl groups into vitamin D compound at the 1.alpha.- and/or 25-positions in the presence of a cyclodextrin compound by the use of a reaction mixture containing a microorganism being capable of hydroxylating vitamin D compound or a enzyme produced from the microorganism, is disclosed.Type: GrantFiled: June 7, 1991Date of Patent: December 12, 1995Assignee: Mercian CorporationInventors: Koji Takeda, Kiyoshi Kimura, Kazuhiko Okamura, Rokuro Okamoto, Joji Sasaki, Takashi Adachi, Sadafumi Omura
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Patent number: 4975370Abstract: Mucor circinelloides f. griseo-cyanus IFO 4563 is cultivated in a medium containing 6-O-methylerythromycin A as a substrate to obtain 14-hydroxy-6-O-methyl-erythromycin A. This compound and its salt have anti-bacterial activity.Type: GrantFiled: April 28, 1987Date of Patent: December 4, 1990Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Joji Sasaki, Kazutoshi Mizoue, Takashi Adachi, Takatoshi Nagate, Shigeo Morimoto, Sadafumi Omura
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Patent number: 4902781Abstract: Tripeptide derivatives of the formula ##STR1## wherein R is a formyl group or a dimethoxymethyl group have antitumor and enzyme inhibition effects.Type: GrantFiled: November 21, 1988Date of Patent: February 20, 1990Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kazutoshi Mizoue, Tadayasu Okazaki, Kazunori Hanada, Sadafumi Omura, Toshiro Amamoto
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Patent number: 4892821Abstract: A method for introducing hydroxyl groups into vitamin D compounds at 1.alpha.- and/or 25-positions by use of a solution containing the mycelium of Actinomycetales being capable of hydroxylating vitamin D compound or the enzyme produced from the mycelium, is disclosed.Type: GrantFiled: July 5, 1988Date of Patent: January 9, 1990Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Sadafumi Omura, Joji Sasaki, Akiko Mikami, Kazutoshi Mizoue
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Patent number: 4680311Abstract: Method for the treatment of systemic mycosis of mammals comprises administering (S)-2-amino-5-hydroxy-4-oxopentanoicacid in a therapeutically effective amount to said mammals suffering from mycosis, typically candidosis.Type: GrantFiled: April 7, 1986Date of Patent: July 14, 1987Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Naoharu Watanabe, Kazuo Numata, Michio Yamagishi, Taku Mizutani, Sadafumi Omura, Hideyo Yamaguchi
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Patent number: 4507232Abstract: This invention is directed to novel peptide derivatives. Said peptide derivatives are useful as a substrate for the activity assay of enzymes of the group EC 3. 4. 22, for example, cathepsin L, cathepsin B and cathepsin H. Said peptide derivatives which contain L-methionine radical are prepared according to the methods conventional in peptide chemistry. As typical examples are mentioned D-leucyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate, .beta.-alanyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate and succinyl-L-tyrosyl-L-methionine-p-nitroanilide.Type: GrantFiled: December 16, 1983Date of Patent: March 26, 1985Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masaharu Tamai, Takashi Adachi, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura, Nobuhiko Katunuma
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Patent number: 4496717Abstract: Novel erythromycin B derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each hydrogen or methyl, and the pharmaceutically acceptable acid addition salts thereof are disclosed. They exhibit excellent in vivo antibacterial activity against Gram-positive bacteria.Type: GrantFiled: November 24, 1982Date of Patent: January 29, 1985Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Takashi Adachi, Shigeo Morimoto, Yoko Takahashi, Yoshiaki Watanabe, Sadafumi Omura
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Patent number: 4476298Abstract: Novel erythromycin A derivatives of the formula ##STR1## wherein R is hydrogen or methyl, and the pharmaceutically acceptable acid addition salts thereof are disclosed. They exhibit excellent antibacterial activity against erythromycin resistant bacteria, Gram-positive bacteria and Mycoplasma species.Type: GrantFiled: November 24, 1982Date of Patent: October 9, 1984Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Shigeo Morimoto, Yoko Takahashi, Yoshiaki Watanabe, Sadafumi Omura
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Patent number: 4474800Abstract: An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, benzyl or cycloalkyl having 5 to 6 carbon atoms, R.sup.2 is alkyl having 3 to 4 carbon atoms, R.sup.3 is hydrogen, benzyloxycarbonyl, acetyl or benzoyl, and n is an integer of 2 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.Type: GrantFiled: May 13, 1980Date of Patent: October 2, 1984Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masaharu Tamai, Shigeo Morimoto, Takashi Adachi, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
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Patent number: 4418075Abstract: An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen or alkali metal, R.sup.2 is isobutyl, R.sup.3 is hydrogen or benzyloxycarbonyl, and n is an integer of 5 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.Type: GrantFiled: November 10, 1981Date of Patent: November 29, 1983Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masaharu Tamai, Shigeo Morimoto, Takashi Adachi, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
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Patent number: 4393228Abstract: The epoxysuccinic acid derivatives of this invention are prepared by esterification of an epoxysuccinic acid or a halide thereof, by partial hydrolysis of an epoxysuccinic acid diester, by amidation of an epoxysuccinic acid monoester, or by hydrolysis of an epoxysuccinic acid amide monoester. These epoxysuccinic acid derivatives have excellent thiol protease inhibitory activity and anti-inflammatory activity without the acceleration of vascular permeability.Type: GrantFiled: February 22, 1978Date of Patent: July 12, 1983Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Jiro Sawada, Kazunori Hanada, Masaharu Tamai, Shigeo Morimoto, Sadafumi Omura
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Patent number: 4382889Abstract: An epoxysuccinic acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R.sup.2 is alkyl having 3-4 carbon atoms or benzyl, R.sup.3 is hydrogen or methyl, and R.sup.4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl, cycloalkyl having 3-6 carbon atoms or a group of the formula ##STR2## wherein R.sup.5 is hydrogen, alkyl having 1-4 carbon atoms or said alkyl substituted with hydroxy, methylmercapto, phenyl, hydroxyphenyl, indolyl, an optionally protected carboxy, an optionally protected amino or an optionally protected guanidino, and R.sup.6 is hydroxy, alkalimetaloxy, alkoxy having 1-2 carbon atoms, benzyloxy, amino or dimethylamino, or R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.Type: GrantFiled: December 30, 1981Date of Patent: May 10, 1983Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masahuru Tamai, Takashi Adachi, Shigeo Morimoto, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
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Patent number: 4366311Abstract: A novel compound of the formula ##STR1## and the salts thereof, derived from dianemycin, are useful as antiprotozoal and antibacterial agents.Type: GrantFiled: September 18, 1981Date of Patent: December 28, 1982Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Taku Mizutani, Michio Yamagishi, Kazutoshi Mizoue, Akira Kawashima, Sadafumi Omura, Noboru Otake, Haruo Seto
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Patent number: 4359583Abstract: The novel antibiotics represented by the formula ##STR1## wherein either (a) R.sup.1 is hydroxy and R.sup.2 is hydrogen, or (b) R.sup.1 is methoxy and R.sup.2 is hydroxy, and the salt thereof, are produced by the cultivation of the organism Streptomyces hygroscopicus TM-531 under aerobic conditions. They are separated from coproduced Antibiotic TM-531 as disclosed in U.S. Pat. No. 4,269,971 and from each other by chromatography on silica gel.Type: GrantFiled: September 15, 1981Date of Patent: November 16, 1982Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Taku Mizutani, Michio Yamagishi, Kazutoshi Mizoue, Akira Kawashima, Sadafumi Omura, Noboru Otake, Haruo Seto
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Patent number: 4333879Abstract: An epoxysuccinic acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R.sup.2 is alkyl having 3-4 carbon atoms or benzyl, R.sup.3 is hydrogen or methyl, and R.sup.4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl or cycloalkyl having 3-6 carbon atoms or R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.Type: GrantFiled: January 3, 1980Date of Patent: June 8, 1982Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masaharu Tamai, Takashi Adachi, Shigeo Morimoto, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
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Patent number: 4331803Abstract: Novel erythromycin compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or methyl, and a pharmaceutically acceptable salt thereof are disclosed. They exhibit excellent antibacterial activity against Gram-positive bacteria, acid stability and in vivo activity.Type: GrantFiled: May 19, 1981Date of Patent: May 25, 1982Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yoshiaki Watanabe, Shigeo Morimoto, Sadafumi Omura
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Patent number: 4269971Abstract: Antibiotic TM-531 having the formula: ##STR1## TM-531 is effective against gram-positive bacteria, plant pathogenic microorganisms and protozoa.Type: GrantFiled: December 31, 1979Date of Patent: May 26, 1981Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Michio Yamagishi, Akira Kawashima, Taku Mizutani, Hiroshi Hara, Kazutoshi Mizoue, Sadafumi Omura, Haruo Seto, Noboru Otake
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Patent number: 4199515Abstract: Novel lonomycin derivatives, prepared by reacting lonomycin or its salt with an alkali or an alkali metal borohydride, show antibacterial, antiviral and antiprotozoal activity, and have decreased toxicity as compared with lonomycin.Type: GrantFiled: March 9, 1979Date of Patent: April 22, 1980Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Michio Yamagishi, Kazutoshi Mizoue, Taku Mizutani, Hiroshi Hara, Sadafumi Omura, Haruo Seto, Noboru Otake
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Patent number: 4197292Abstract: Novel oligosaccharide substances, TAI-A and TAI-B, possessing a strong inhibitory activity to amylase and invertase are obtained by inoculating a seed of the strain of Streptomyces calvus TM-521 into aqueous nutrient medium, cultivating this with shaking or by a submerged culture method with aeration, and separating the produced amylase inhibitors TAI-A and TAI-B from the cultured broth.Type: GrantFiled: February 2, 1979Date of Patent: April 8, 1980Assignee: Taisho Pharmaceutical Co.Inventors: Kunio Kangouri, Shinjuro Namiki, Takatoshi Nagate, Kazuhiko Sugita, Sadafumi Omura
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Patent number: 3950514Abstract: A new polyether group antibiotic, TM-481, having the estimated empirical formula C.sub.42-45 H.sub.71-75 O.sub.14-15 Na and possessing an antibacterial activity against pathogenic microorganisms, particularly Gram-positive bacteria is obtained by culturing a TM-481 producing microorganism of the Streptomyces ribosidificus group in a nutrient medium therefor.Type: GrantFiled: September 4, 1974Date of Patent: April 13, 1976Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Jiro Sawada, Sadafumi Omura, Michinori Shibata, Sadao Machida