Patents by Inventor Sadahiro Shimizu

Sadahiro Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enantiomerically pure substituted oxaaza compounds, salts of the same, and processes for the preparation of both
    Patent number: 6423843
    Abstract: This invention provides a method for conveniently obtaining a compound of formula (Ia) which is a production intermediate of antimicrobial compounds, in which a salt of optically active acid of formula (IIIa) is obtained by allowing a compound of formula (I), a ketone compound and an optically active acid to react with one another, converted into its free form and then hydrolyzed. In the formula, R1: hydrogen atom or alkyl, aryl or aralkyl group; R2: hydrogen atom or alkyl, aryl, aralkyl, acyl, alkyloxycarbonyl, aralkyloxycarbonyl or substituted sulfonyl; these may further have substituents.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: July 23, 2002
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Naoki Ohta, Toru Makino, Sadahiro Shimizu
  • Production process of cyclic compound
    Patent number: 6218548
    Abstract: A compound represented by formula (III): wherein n is an integer of 2 to 5; and R11 represents a substituent group represented by formula: wherein Ra, Rb and Rc each represents a phenyl, phenylmethyl or naphthyl group (which may be substituted with at least one substituent group selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a halogen atom and a nitro group), a hydrogen atom, or an alkyl group having 1 to 4 carbon atoms, with the proviso that Ra, Rb and Rc are different from one another, and a salt thereof.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: April 17, 2001
    Assignee: Daiichi Paharmaceutical Co., Ltd.
    Inventors: Toshifumi Akiba, Tutomu Ebata, Tatsuru Saito, Sadahiro Shimizu, Keiichi Hirai, Naoki Ohta, Toshiaki Tojo
  • Production process of cyclic compound
    Patent number: 6013806
    Abstract: This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of formula (I), and also to provide a novel synthetic process for the inexpensive, short-step and industrially advantageous production thereof.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: January 11, 2000
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Toshifumi Akiba, Tutomu Ebata, Tatsuru Saito, Sadahiro Shimizu, Keiichi Hirai, Naoki Ohta, Toshiaki Tojo
  • Production process of cyclic compound
    Patent number: 5856518
    Abstract: This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of folmula (I), and also to provide a novel synthetic process for the inexpensive, short-step and industrially advantageous production thereof.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 5, 1999
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Toshifumi Akiba, Tutomu Ebata, Tatsuru Saito, Sadahiro Shimizu, Keiichi Hirai, Naoki Ohta, Toshiaki Tojo
  • Diamine compound and brain protecting agent containing the same
    Patent number: 5389630
    Abstract: Diamine compounds of formula (I) or an addition salt thereof are provided: ##STR1## These compounds have an excellent cerebral protective action, are very safe, and exhibit a strong action when orally administered, and therefore, medicines containing such compounds are effective for treating disorders caused by cerebral hemorrhage, cerebral infarction, subarachnoid hemorrhage, transient ischemic attack, cerebrovascular disorders and the like, or preventing progress of such disorders.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: February 14, 1995
    Assignee: Kowa Co., Ltd.
    Inventors: Seiichi Sato, Kiyoshi Kawamura, Yoshio Takahashi, Koichiro Watanabe, Sadahiro Shimizu, Tomio Ohta