Abstract: Novel cephalosporin derivatives of formula (II): ##STR1## wherein R.sup.2 is hydrogen, methyl, or fluoromethyl; R.sup.3 is hydrogen, methyl or carboxyl; R.sup.4 is hydrogen or methyl; A is methylene or propenylene; Q is nitrogen or CH, and pharmaceutically acceptable salts, solvates, hydrates and esters thereof, a process for their preparation and an antimicrobial composition containing them.

Abstract: Herein disclosed are novel cephem compounds represented by the following general formula (I), and novel antimicrobial, and especially anti-MRSA, agents which contain as an active ingredient at least one of the novel cephem compounds and the physiologically acceptable salts thereof.

Abstract: A method of separating chemical components in a simulated-moving-bed type continuous separator comprising a series of plural packed beds filled with adsorbent for selectively adsorbing a specific component in a crude solution, in which the packed beds are divided into three zones, and the functions assigned to the respective packed beds are successively shifted to the downstream side of the flow by the quantity of one bed by means of switching means such as a channel switching control valve comprising a stationary disc and a rotary disc rotatable thereon, thereby extracting a product solution containing a high percentage of the specific component.

Abstract: A flexible dumbbell comprises a cylindrical body of elastic material such as rubber formed in predetermined length and diameter suitable for various kinds of physical exercises or running, and a flexible core element of predetermined weight suitable for a user's physique contained within the cylindrical body to provide radial resiliency of the dumbbell. The cylindrical body is closed in an appropriate manner at the opposite ends thereof to retain the core element in place.

Abstract: Antibacterial 7-substituted aminoacetamido oxadethiacephalosporins of the formula: ##STR1## [wherein R is substituted amino, substituted phenyl, or 5- or 6-membered hetero ring; Ar is aryl; Y is hydrogen or methoxy; Het is 5- or 6-membered aromatic hetero ring; and Z is hydroxy or carboxy protecting group] preparable e.g. by acylation of 7.alpha.-methoxy-7.beta.-amino-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives, are highly active against gram-positive and gram-negative bacteria, especially those resistant to other cephalosporins and penicillins.

Abstract: Antibacterial haloarylmalonamido-1-dethia-1-oxacephalosporins of the following formula: ##STR1## wherein Ar is ##STR2## (in which Hal and Hal' each is halogen and RO is hydroxy or protected hydroxy);COA and COB each is carboxy or protected carboxy including a pharmaceutically acceptable salt group;and Het is 1-lower alkyl-5-tetrazolyl, 1,3,4-thiadiazol-2-yl or 5-lower alkyl-1,3,4-thiadiazol-2-yl,a pharmaceutical or veterinary composition comprising the said haloarylmalonamido-1-dethia-1-oxacephalosporin and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering an effective amount of the said antibacterial compound.