Patents by Inventor Sadao Manabe

Sadao Manabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for prophylaxis of influenza using vaccine for intranasal administration
    Patent number: 9603919
    Abstract: The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 28, 2017
    Assignees: JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES, THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY, TOKO YAKUHIN KOGYO KABUSHIKI KAISHA
    Inventors: Hideki Hasegawa, Sadao Manabe, Takeshi Tanimoto, Takashi Miyazaki, Taizou Kamishita
  • METHOD FOR PROPHYLAXIS OF INFLUENZA USING VACCINE FOR INTRANASAL ADMINISTRATION
    Publication number: 20120082697
    Abstract: The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.
    Type: Application
    Filed: March 31, 2010
    Publication date: April 5, 2012
    Applicants: JAPAN AS REPRESENTED BY THE DIRECTOR GENERAL OF NATL. INST. OF INFECT DISEASES, TOKO YAKUHIN KOGYO KABUSHIKI KAISHA, The Research Foundaton for Microbial Diseases of Osaka University
    Inventors: Hideki Hasegawa, Sadao Manabe, Takeshi Tanimoto, Takashi Miyazaki, Taizou Kamishita
  • Process for expressing the hepatitis B virus antigen using a Saccharomyces cerevisiae transformant
    Patent number: 5693497
    Abstract: There is disclosed an antigen comprising an amino acid sequence of the suce antigen of a hepatitis B virus. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for hepatitis B.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: December 2, 1997
    Assignee: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Akihisa Takamizawa, Hiroyuki Fujita, Sadao Manabe, Masahiko Kato, Juichiro Osame, Iwao Yoshida, Takeo Konobe, Keisuke Takaku
  • Recombinant Marek's disease virus and vaccine
    Patent number: 5650153
    Abstract: There is provided a recombinant Marek's disease virus comprising the genomic DNA of an attenuated Marek's disease virus and a foreign gene from another source. The present recombinant virus can advantageously be used as an active ingredient for a multifunctional live vaccine, exhibiting not only the antigenicity and immunogenicity of the Marek's disease virus but also the properties ascribed to the foreign gene. Since the suitable host cell for the recombinant virus of the present invention is an avian cell which is available in a large quantity and not expensive, the recombinant virus of the present invention can be produced efficiently at low cost on a commercial scale.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: July 22, 1997
    Assignee: The Research Foundation for Microbial Diseases
    Inventors: Toyokazu Ishikawa, Sadao Manabe, Chisato Mori, Akihisa Takamizawa, Iwao Yoshida, Juichiro Osame, Keisuke Takaku, Konosuke Fukai
  • A DNA coding for a Flavivirus antigen
    Patent number: 5486473
    Abstract: There is disclosed a DNA which codes for an antigen comprising at least part of an amino acid sequence of the antigen of a flavivirus, which part contains at least one epitope of the flavivirus antigen. The present DNA can be used for producing the antigen easily and safely at low cost by means of recombinant DNA technique. The antigen produced using the present DNA can be used as an effective vaccine and diagnostic for Japanese encephalitis.
    Type: Grant
    Filed: February 9, 1994
    Date of Patent: January 23, 1996
    Assignee: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Hiroyuki Fujita, Iwao Yoshida, Mitsuo Takagi, Sadao Manabe, Konosuke Fukai
  • Flavivirus antigen
    Patent number: 4810492
    Abstract: There is disclosed an antigen comprising at least part of an amino acid sence of the antigen of a flavivirus, which part contains at least one of epitopes of the flavivirus antigen. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for Japanese encephalitis.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: March 7, 1989
    Assignee: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Hiroyuki Fujita, Iwao Yoshida, Mitsuo Takagi, Sadao Manabe, Konosuke Fukai