Patents by Inventor Sadettin Seyit OZTURK

Sadettin Seyit OZTURK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCEMENT OF RECOMBINANT PROTEIN EXPRESSION WITH COPPER
    Publication number: 20170067013
    Abstract: The present invention provides a novel use of copper (cupric ion) for improved cell expression of recombinant proteins, particularly coagulation proteins such as recombinant Factor VIII, B Domain Deleted recombinant Factor VIII, recombinant Factor IX and rFVII or rFVIIa. The use of such cell culture supplement results in higher productivity and robustness of the manufacturing process. This invention results in improvements in cell expression and product stability.
    Type: Application
    Filed: March 3, 2015
    Publication date: March 9, 2017
    Applicant: Advantech Bioscience Farmacêutical LTDA
    Inventors: Sadettin Seyit OZTURK, Matthew Veron CAPLE
  • ENHANCEMENT OF RECOMBINANT PROTEIN EXPRESSION USING A MEMBRANE-BASED CELL RETENTION SYSTEM
    Publication number: 20170009269
    Abstract: The invention disclosed herein provides a novel use of an external membrane-based cell retention system in conjunction with perfusion cell culture for improved cell expression of recombinant proteins, particularly coagulation proteins such as rFVIII, B-Domain Deleted rFVIII, rFIX or rFVII/rFVIIa. The use of such a system at high cell density results in a more homogeneous cell culture due to mechanical forces induced during the operation of the retention system, such as the cell circulation induced by pumping through the fibers.
    Type: Application
    Filed: February 12, 2015
    Publication date: January 12, 2017
    Inventor: Sadettin Seyit OZTURK