Patents by Inventor Sadik Kassim

Sadik Kassim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS RELATING TO GENETICALLY ENGINEERED CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20230414755
    Abstract: The disclosure is directed to methods and compositions relating to genetically engineered cells expressing chimeric antigen receptors, where the cells are mobilized lymphocytes.
    Type: Application
    Filed: November 12, 2021
    Publication date: December 28, 2023
    Applicant: VOR BIOPHARMA INC.
    Inventors: Sadik Kassim, Julian Scherer, Giacomo Canesin, Tirtha Chakraborty
  • CHIMERIC ANTIGEN RECEPTORS FOR TREATMENT OF CANCER
    Publication number: 20230372484
    Abstract: Provided are chimeric antigen receptors (CARs) with binding specificity for CD33. Nucleic acids, vectors, host cells, populations of cells expressing the CARs, and pharmaceutical compositions relating to the CARs are also disclosed, and methods including the treatment of CD33-related diseases, in particular, leukemias such as acute myeloid leukemia (AML).
    Type: Application
    Filed: September 14, 2021
    Publication date: November 23, 2023
    Applicant: VOR BIOPHARMA INC.
    Inventors: Sadik Kassim, Julian Scherer
  • SINGLE DOMAIN ANTIBODIES AGAINST CD33
    Publication number: 20230365675
    Abstract: The present disclosure includes antibodies that specifically CD33, as well as methods of making and using such antibodies.
    Type: Application
    Filed: September 14, 2021
    Publication date: November 16, 2023
    Applicant: VOR BIOPHARMA INC.
    Inventors: Sadik Kassim, Julian Scherer
  • CHIMERIC ANTIGEN RECEPTOR EXPRESSION SYSTEMS
    Publication number: 20230364137
    Abstract: Aspects of this disclosure provide nucleic acid constructs A nucleic acid construct, comprising a first expression cassette comprising a nucleic acid encoding a tetracycline-responsive transactivator under the control of a cell type-specific promoter; and a second expression cassette comprising a nucleic acid encoding a transgene, for example, a chimeric antigen receptor (CAR), under the control of a tetracycline-responsive promoter.
    Type: Application
    Filed: September 30, 2021
    Publication date: November 16, 2023
    Applicant: VOR BIOPHARMA INC.
    Inventors: Sadik Kassim, Tirtha Chakraborty, Julian Scherer
  • METHODS OF TREATMENT USING DECITABINE AND A CD123-TARGETED THERAPY
    Publication number: 20200222462
    Abstract: The present disclosure relates generally to methods treatment of hematological cancers, such as blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), or Myelodysplastic Syndrome (MDS), comprising a combination of decitabine and a CD123-targeted therapy. In particular, the disclosed methods involve pretreatment of a patient with decitabine prior to administration of a CD123-targeted therapy.
    Type: Application
    Filed: November 27, 2019
    Publication date: July 16, 2020
    Applicants: Mustang Bio, Inc., City of Hope
    Inventors: Pam Cohen, Sadik Kassim, Ekta Patel, Elizabeth Budde, Stephen J. Forman
  • CHIMERIC ANTIGEN RECEPTOR THERAPY CHARACTERIZATION ASSAYS AND USES THEREOF
    Publication number: 20200061113
    Abstract: In vitro CART characterization assays and methods of using them are disclosed.
    Type: Application
    Filed: April 11, 2019
    Publication date: February 27, 2020
    Inventors: Sadik Kassim, Qiong Xue
  • MANUFACTURING METHODS FOR CELL-BASED THERAPEUTIC COMPOSITIONS
    Publication number: 20190328781
    Abstract: The present disclosure relates generally to methods for preparing cell-based therapeutic compositions for treating hematological cancers. In particular, the disclosure relates to depleting CD56+ cells from cell-based therapeutics used to treat hematological cancers.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 31, 2019
    Applicant: Mustang Bio, Inc.
    Inventors: Sadik Kassim, Kenny Choi