Abstract: The present invention relates to a composition for inhibiting HIV activity comprising the extract of Paecilomyces sp. (Tochu-kaso) J300. More particularly, the present invention relates to a composition for inhibiting HIV activity comprising 3-[5-(methoxy-ethyl)-3,6-dioxo-piperazine-2-yl]propionic acid represented by Formula 1 and 4-methyl-2-[(pyrrolidine-2-carbonyl)-2-amino]pentanoic acid represented by Formula 2 that are extracted from Paecilomyces sp. (Tochu-kaso) J300; and to a medical composition and food composition containing the same.

Abstract: The present invention relates to a composition for inhibiting HIV activity comprising the extract of Paecilomyces sp. (Tochu-kaso) J300. More particularly, the present invention relates to a composition for inhibiting HIV activity comprising 3-[5-(methoxy-ethyl)-3,6-dioxo-piperazine-2-yl]propionic acid represented by Formula I and 4-methyl-2-[(pyrolidine-2-carbonyl)-2-amino] pentanoic acid represented by Formula 2 that are extracted from Paecilomyces sp. (Tochu-kaso) J300; and to a medical composition and food composition containing the same.

Abstract: Disclosed herein is a cultivation of Paecilomyces sp. which has various efficacies such as anti-tumor and reinforcement of immunity, but could not be used wide in human because of relatively limited supply. The artificial cultivation of Paecilomyces sp. comprises steps of (a) inoculating a dilution of spores of Paecilomyces sp. diluted with water to a concentration of 10.sup.7 .about.10.sup.8 spores/ml into a larva of 4th.about.5th instar of silkworm at a temperature of 26.about.30.degree. C. and a humidity of about 90% or more; and (b) inducing fruitbodies of Paecilomyces sp. by maintaining of the larvae at a temperature of 15.about.30.degree. C. and a humidity of about 90% or more. In particular, Paecilomyces japonica (KCCM-10117), Paecilomyces sp. J300 (KCCM-10116) and Paecilomyces farinosa (KCCM-10115).