Patents by Inventor Saeed R. Khan

Saeed R. Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boronic acid aryl analogs
    Patent number: 8304579
    Abstract: The present invention relates to novel boronic acid aryl derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic acid aryl derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: November 6, 2012
    Assignee: Johns Hopkins University
    Inventor: Saeed R. Khan
  • Boronic Acid Aryl Analogs
    Publication number: 20110105431
    Abstract: The present invention relates to novel boronic acid aryl derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic acid aryl derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Application
    Filed: November 5, 2010
    Publication date: May 5, 2011
    Inventor: Saeed R. Khan
  • Boronic acid aryl analogs
    Patent number: 7829742
    Abstract: The present invention relates to novel boronic acid aryl derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic acid aryl derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: November 9, 2010
    Assignee: Johns Hopkins University
    Inventor: Saeed R. Khan
  • Design and synthesis of renal dipeptidase inhibitors
    Patent number: 7785564
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: August 31, 2010
    Assignee: The Johns Hopkins University
    Inventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults
  • SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS
    Publication number: 20100113491
    Abstract: A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 ?M.
    Type: Application
    Filed: May 26, 2009
    Publication date: May 6, 2010
    Inventors: Saeed R. Khan, Gurulingappa Hallur, Manuel Hidalgo, Antonio Jimeno
  • Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (BPU) sulfur analogs
    Patent number: 7595326
    Abstract: A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 ?M.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: September 29, 2009
    Assignee: Champions Biotechnology, Inc.
    Inventors: Saeed R. Khan, Gurulinsappa Hallur, Manuel Hidalgo, Antonio Jimeno
  • Novel Boronic Chalcone Derivatives and Uses Thereof
    Publication number: 20090227542
    Abstract: The present invention relates to novel boronic chalcone derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic chalcone derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Application
    Filed: March 12, 2009
    Publication date: September 10, 2009
    Inventor: Saeed R. Khan
  • SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS
    Publication number: 20090099218
    Abstract: This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.
    Type: Application
    Filed: September 16, 2008
    Publication date: April 16, 2009
    Inventors: Saeed R. Khan, Gurulingappa Hallur, Manuel Hidalgo, Antonio Jimeno
  • Boronic chalcone derivatives and uses thereof
    Patent number: 7514579
    Abstract: The present invention relates to novel boronic chalcone derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic chalcone derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: April 7, 2009
    Assignees: Johns Hopkins University, Johns Hopkins Technology Transfer
    Inventor: Saeed R. Khan
  • Boronic Acid Aryl Analogs
    Publication number: 20080171723
    Abstract: The present invention relates to novel boronic acid aryl derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic acid aryl derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Application
    Filed: December 21, 2004
    Publication date: July 17, 2008
    Applicant: John Hopkins University, Johns Hopkins Technology Transfer
    Inventor: Saeed R. Khan
  • Design and synthesis of renal dipeptidase inhibitors
    Patent number: 6927212
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: August 9, 2005
    Assignee: The Johns Hopkins University
    Inventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults
  • Design and synthesis of renal dipeptidase inhibitors
    Publication number: 20040091422
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Application
    Filed: July 28, 2003
    Publication date: May 13, 2004
    Applicant: The Johns Hopkins University
    Inventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults