Patents by Inventor Saet-Byeol CHOI

Saet-Byeol CHOI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing of endothelial cells by transformation (transdifferentiation) of adult fibroblast, and use thereof
    Patent number: 10561688
    Abstract: The present invention relates to a method of preparing vascular endothelial cells by transforming (transdifferentiating) adult fibroblasts and a composition, which includes vascular endothelial cells prepared according to the method, for preventing and treating ischemic diseases, the method including a step of transducing adult fibroblasts with a gene. In particular, the present invention confirms that five factors, Foxo1, Er71, Klf2, Tal1, and Lmo2, induce transdifferentiation of adult fibroblasts into induced vascular endothelial cells. Furthermore, the present invention confirms that three factors, Er71, Klf2, and Tal1 induce transdifferentiation of human adult fibroblasts into induced vascular endothelial cells. The resultant induced endothelial cells enable lower limb salvaging by angiogenesis in lower limb ischemic animal models, showing that the induced endothelial cells can be effectively used for prevention or treatment of ischemic diseases.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: February 18, 2020
    Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Hyo-Soo Kim, Jung-Kyu Han, Sung-Hwan Chang, Hyun-Ju Cho, Saet-Byeol Choi, Youngchul Shin
  • METHOD FOR PREPARING OF ENDOTHELIAL CELLS BY TRANSFORMATION (TRANSDIFFERENTIATION) OF ADULT FIBROBLAST, AND USE THEREOF
    Publication number: 20160250263
    Abstract: The present invention relates to a method of preparing vascular endothelial cells by transforming (transdifferentiating) adult fibroblasts and a composition, which includes vascular endothelial cells prepared according to the method, for preventing and treating ischemic diseases, the method including a step of transducing adult fibroblasts with a gene. In particular, the present invention confirms that five factors, Foxo1, Er71, Klf2, Tal1, and Lmo2, induce transdifferentiation of adult fibroblasts into induced vascular endothelial cells. Furthermore, the present invention confirms that three factors, Er71, Klf2, and Tal1 induce transdifferentiation of human adult fibroblasts into induced vascular endothelial cells. The resultant induced endothelial cells enable lower limb salvaging by angiogenesis in lower limb ischemic animal models, showing that the induced endothelial cells can be effectively used for prevention or treatment of ischemic diseases.
    Type: Application
    Filed: May 13, 2016
    Publication date: September 1, 2016
    Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Hyo-Soo KIM, Jung-Kyu HAN, Sung-Hwan CHANG, Hyun-Ju CHO, Saet-Byeol CHOI, Youngchul SHIN