Patents by Inventor Sagi Raz

Sagi Raz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11717652
    Abstract: The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by \ operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: August 8, 2023
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Ronan Keating, Shahaf Marmur, Or Inbar, Eamon Brady, Gerry McCaffrey, Reed Williston, Sagi Raz
  • Patent number: 11660426
    Abstract: The disclosure relates to devices and methods for the treatment of edema that uses an impeller with a balloon that may be mounted on the impeller housing. The invention provides devices and methods for treatment of edema that use an indwelling catheter with an impeller to lower pressure at an outlet of a lymphatic duct and a balloon on the impeller to guide and to restrict blood flow. The balloon restricts return flow from the jugular and guides that flow into the impeller cage. By funneling the flow into the impeller cage, a rate of flow down the vessel may be increased, resulting in a lateral pressure decrease effecting the lymphatic outlet. Because the lymphatic outlet is subject to a pressure decrease, fluids in the lymphatic system drain to the outlet and into the circulatory system.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: May 30, 2023
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Ronan Keating, Shahaf Marmur, Or Inbar, Eamon Brady, Gerry McCaffrey, Reed Williston, Sagi Raz
  • Publication number: 20220280762
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 8, 2022
    Inventors: Yaacov Nitzan, Sagi Raz, Shani Chen, Or Inbar
  • Publication number: 20220280761
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 8, 2022
    Inventors: Yaacov Nitzan, Sagi Raz, Shani Chen, Or Inbar
  • Patent number: 11357959
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 14, 2022
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Sagi Raz, Shani Chen, Or Inbar
  • Publication number: 20220104827
    Abstract: This disclosure relates to a catheter system that for precisely positioning fluid flow restrictors within a blood vessel. In particular, this disclosure provides a catheter system that includes a sheath with a first fluid flow restrictor mounted thereto, and a catheter that is slidably disposed within the sheath and has a second fluid flow restrictor mounted thereto. Inside a blood vessel, the sheath and the catheter are separately slidable, thereby allowing the first and second fluid flow restrictors to be positioned at precise locations within the blood vessel.
    Type: Application
    Filed: October 1, 2021
    Publication date: April 7, 2022
    Inventors: Ronan Keating, Or Inbar, Ilan Grunberg, Sagi Raz, Gerry Mccaffrey, Eamon Brady
  • Publication number: 20220104828
    Abstract: This disclosure relates to a catheter with a fluid flow restrictor (e.g., a balloon) that includes a flow path. The catheter is useful for creating, and maintaining, an area of reduced pressure within a blood vessel for removing excess fluid from a patient's body. In particular, the catheter is dimensioned for insertion into a blood vessel and includes a fluid flow restrictor that, when deployed, partially occludes the blood vessel. Pressure is reduced within the blood vessel downstream of the occlusion. The flow path allows some blood to flow past the restrictor, which prevents the blood vessel from stretching due to excessive pressure buildup, thereby allowing the area of reduced pressure to be maintained for extended periods of time.
    Type: Application
    Filed: October 1, 2021
    Publication date: April 7, 2022
    Inventors: Ronan Keating, Or Inbar, Ilan Grunberg, Sagi Raz, Gerry Mccaffrey, Eamon Brady
  • Publication number: 20210378677
    Abstract: The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and/or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.
    Type: Application
    Filed: June 8, 2021
    Publication date: December 9, 2021
    Inventors: Ronan Keating, Eamon Brady, Gerry McCaffrey, Sagi Raz, Or Inbar, Ann Marie Cannon
  • Publication number: 20210378678
    Abstract: The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and/or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.
    Type: Application
    Filed: June 8, 2021
    Publication date: December 9, 2021
    Inventors: Ronan Keating, Eamon Brady, Gerry McCaffrey, Sagi Raz, Or Inbar
  • Publication number: 20210379329
    Abstract: The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and/or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.
    Type: Application
    Filed: June 8, 2021
    Publication date: December 9, 2021
    Inventors: Ronan Keating, Eamon Brady, Gerry McCaffrey, Sagi Raz, Or Inbar
  • Publication number: 20210378676
    Abstract: The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and/or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.
    Type: Application
    Filed: June 8, 2021
    Publication date: December 9, 2021
    Inventors: Ronan Keating, Eamon Brady, Gerry McCaffrey, Sagi Raz, Or Inbar
  • Publication number: 20210121678
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct such as the thoracic duct or the lymphatic duct. A catheter system can include a catheter shaft configured to be at least partially implantable within a patient's vein, a flexible membrane attached to the catheter shaft, the flexible membrane being a collapsible, tube-like member having a lumen extending therethrough, and a single selectively deployable restriction member formed over a portion of the flexible membrane at substantially a midpoint between a proximal end of the flexible membrane and a distal end of the flexible membrane, the restriction member being configured to control a size of the lumen so as to direct a controlled volume of fluid from an upstream side of the restriction member to a downstream side the restriction member.
    Type: Application
    Filed: January 5, 2021
    Publication date: April 29, 2021
    Inventors: Yaacov Nitzan, Menashe Yacoby, Sagi Raz, Shani Chen, Or Inbar
  • Patent number: 10960189
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: March 30, 2021
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Sagi Raz, Shani Chen, Or Inbar
  • Publication number: 20210077247
    Abstract: A multi-component stent-graft system (10) comprises first, second, and third generally tubular stent-grafts (20, 22, 24), which are configured to assume radially-expanded states. The first stent-graft (20) is shaped so as to define a first lateral opening (34) when in its radially-expanded state. The second stent-graft (22) is shaped so as to define a second lateral opening (44) when in its radially-expanded state. The first and second stent-grafts (20, 22) are configured such that the second stent-graft (22) forms a blood-impervious seal with the first stent-graft (20) around the first lateral opening (34) when the second stent-graft (22) is disposed therethrough, and the first and the second stent-grafts (20, 22) are in their radially-expanded states.
    Type: Application
    Filed: December 1, 2020
    Publication date: March 18, 2021
    Applicant: ENDOSPAN LTD.
    Inventors: Alon SHALEV, Sagi RAZ, Rafi BENARY
  • Patent number: 10912873
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct such as the thoracic duct or the lymphatic duct. A catheter system can include a catheter shaft configured to be at least partially implantable within a patient's vein, a flexible membrane attached to the catheter shaft, the flexible membrane being a collapsible, tube-like member having a lumen extending therethrough, and a single selectively deployable restriction member formed over a portion of the flexible membrane at substantially a midpoint between a proximal end of the flexible membrane and a distal end of the flexible membrane, the restriction member being configured to control a size of the lumen so as to direct a controlled volume of fluid from an upstream side of the restriction member to a downstream side the restriction member.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: February 9, 2021
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Menashe Yacoby, Sagi Raz, Shani Chen, Or Inbar
  • Patent number: 10888413
    Abstract: A multi-component stent-graft system is provided, which includes a first stent-graft, which is configured to assume radially-expanded and radially-compressed states; and a second stent-graft, which is configured to assume radially-expanded and radially-compressed states. A delivery tool includes an outer tube, in which the first and the second stent-grafts are initially positioned at respective axial sites within the outer tube, in their radially-compressed states without being fixed to each other. Other embodiments are also described.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: January 12, 2021
    Assignee: ENDOSPAN LTD.
    Inventors: Alon Shalev, Sagi Raz, Rafi Benary
  • Publication number: 20200397963
    Abstract: The disclosure provides an intravascular catheter with a purge system that excludes biological fluids and may also include devices such as impellers that can be delivered over, and operated over, a guidewire. Catheters may include treatment devices suited to the treatment of edema and in which the guidewire aids in positioning the device while the purge system facilitates reliable operation.
    Type: Application
    Filed: February 12, 2019
    Publication date: December 24, 2020
    Inventors: Yaacov Nitzan, Sagi Raz
  • Publication number: 20190183630
    Abstract: A multi-component stent-graft system is provided, which includes a first stent-graft, which is configured to assume radially-expanded and radially-compressed states; and a second stent-graft, which is configured to assume radially-expanded and radially-compressed states. A delivery tool includes an outer tube, in which the first and the second stent-grafts are initially positioned at respective axial sites within the outer tube, in their radially-compressed states without being fixed to each other. Other embodiments are also described.
    Type: Application
    Filed: December 21, 2018
    Publication date: June 20, 2019
    Applicant: ENDOSPAN LTD.
    Inventors: Alon SHALEV, Sagi RAZ, Rafi BENARY
  • Patent number: 10226604
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 12, 2019
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Sagi Raz, Shani Chen, Or Inbar
  • Patent number: 10226605
    Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 12, 2019
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Sagi Raz, Shani Chen, Or Inbar