Patents by Inventor Sagrario M. Del Val

Sagrario M. Del Val has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotic agent
    Patent number: 5091413
    Abstract: An antibiotic agent produced by the cultivation of Dictyochaeta simplex is described. The compound has broad antifungal activity and antipneumocystis activity.
    Type: Grant
    Filed: February 13, 1990
    Date of Patent: February 25, 1992
    Assignee: Merck & Co., Inc.
    Inventors: George M. Garrity, Sagrario M. Del Val, Mary Nallin, Dennis M. Schmatz, Jack L. Smith, Frank L. VanMiddlesworth, Kenneth E. Wilson, Marcia M. Zweerink
  • Novel HMG-CoA synthase inhibitors
    Patent number: 5064856
    Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: November 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: George M. Garrity, Robert Giacobbe, Michael D. Greenspan, Otto D. Hensens, Henry Joshua, Maria T. D. Matas, Isabel Martin, James A. Milligan, Sagrario M. del Val, Walter Rozdilsky, Janet C. Onishi, Jerrold M. Liesch
  • Drug for treating manic depression
    Patent number: 4981980
    Abstract: Fermentation of a nutrient medium by a Hypomycetes fungus of the genus Memnoniella or Stachybotrys yields a product with a major component of structural formula I: ##STR1## which is an inositol monophosphate phosphatase inhibitor and thereby useful in the treatment of manic depression.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: January 1, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Giocobbe, Leeyuan Huang, Yu L. Kong, Yiu-Kuen T. Lam, Sagrario M. Del Val, Carol F. Wichmann, Deborah L. Zink
  • Process for antifungal fermentation product
    Patent number: 4968608
    Abstract: An antifungal agent produced by cultivation of Zalerion arboricola is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
    Type: Grant
    Filed: October 7, 1987
    Date of Patent: November 6, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Giacobbe, Sagrario M. Del Val, Richard L. Monaghan, Robert E. Schwartz
  • Process for producing L-654,040, antibacterial agent
    Patent number: 4960698
    Abstract: L-654,040 of the structure: ##STR1## is a novel antibacterial and isolated from the novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: October 2, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Sara A. Currie, Thomas W. Miller, Eugene L. Dulaney, James P. Springer, Mary E. Valiant, Sagrario M. del Val, Sheldon B. Zimmerman
  • Culture of Streptoverticillium synroense for producing an antibacterial
    Patent number: 4956294
    Abstract: The novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC under Accession No.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: September 11, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Sara A. Currie, Thomas W. Miller, Eugene L. Dulaney, James P. Springer, Mary E. Valiant, Sheldon B. Zimmerman, Sagrario M. Del Val
  • Antifungal agent
    Patent number: 4952604
    Abstract: Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: August 28, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Otto D. Hensens, Jerrold M. Liesch, James A. Milligan, Sagrario M. Del Val, Robert E. Schwartz, Carol Wichmann
  • Antifungal fermentation product
    Patent number: 4931352
    Abstract: An antifungal agent produced by cultivation of a yet unidentified microorganism is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
    Type: Grant
    Filed: June 7, 1989
    Date of Patent: June 5, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Fromtling, Robert A. Giacobbe, Jerrold M. Liesch, Sagrario M. Del Val, Robert E. Schwartz, Carol F. Wichmann
  • Process for the manufacture of an antifungal antihypercholesterolemic .beta .
    Patent number: 4828992
    Abstract: The process for the manufacture of the compound of the general structural formula ##STR1## which is a 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitor and useful as an antihypercholesterolemic agent for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, and which is an antifungal agent is disclosed.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: May 9, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Sagrario M. Del Val, Maria I. M. Fernandez, Richard L. Monaghan
  • Process for the preparation of difficidin and derivative antibacterials
    Patent number: 4681846
    Abstract: Process for the preparation of difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: May 6, 1985
    Date of Patent: July 21, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth E. Wilson, Richard L. Monaghan, Cheryl DeRiso, Sheldon B. Zimmerman, Otto D. Hensens, James E. Flor, Sagrario M. Del Val, Maria I. M. Fernandez
  • Difficidin and derivative antibacterials
    Patent number: 4545991
    Abstract: Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: October 8, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, Kenneth E. Wilson, Richard L. Monaghan, Sagrario M. Del Val, Maria I. M. Fernandez, Otto D. Hensens, James E. Flor, Cheryl Deriso