Patents by Inventor Sagrario Mochales

Sagrario Mochales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunosuppressant-producing culture
    Patent number: 5202258
    Abstract: Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: April 13, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, Byron H. Arison, George M. Garrity, Edward S. Inamine, Sagrario Mochales, Linda S. Wicker
  • Xanthomegnin, a known compound, is an antiparasitic agent
    Patent number: 5017603
    Abstract: The controlled aerobic fermentation of the fungal organism Fusarium lateritium var. longum produces xanthomegnin. Xanthomegnin has been discovered to have potent parasiticidal, anthelminthic, and insecticidal activity.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: May 21, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Dan A. Ostlind, Sagrario Mochales
  • L-654,040, antibacterial agent
    Patent number: 4963569
    Abstract: L-654,040 of the structure: ##STR1## is a novel antibacterial and isolated from the novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Sara A. Currie, Thomas W. Miller, Eugene L. Dulaney, James P. Springer, Mary E. Valiant, Sagrario Mochales del Val, Sheldon B. Zimmerman
  • Sterol inhibitors of testosterone 5.alpha.-reductase
    Patent number: 4814324
    Abstract: The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5.alpha.-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.
    Type: Grant
    Filed: March 6, 1987
    Date of Patent: March 21, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Robert P. Borris, Richard W. Burg, Otto D. Hensens, Leeyuan Huang, Livia Kelemen, Sagrario Mochales
  • Synergistic combinations of phosphonomycin and bacteriostatic agents
    Patent number: 3935309
    Abstract: Pathogens are controlled by concomitant contact with a phosphonomycin antibiotic and a bacteriostatic chemotherapeutic compound by separate or simultaneous administration. The combined action is especially advantageous in contacting resistant microorganisms and other microorganisms which are oridinarily not controlled by contact with the individual chemotherapeutic agents.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: January 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: David Hendlin, Justo Martinez Mata, Sagrario Mochales Del Val, Edward O. Stapley