Abstract: The present disclosure generally relates to systems and methods for determining and/or monitoring a sleep stage and/or a sleep quality metric for an individual using one or more sensors, and methods of treating medical conditions related thereto (e.g., obstructive sleep apnea).

Abstract: The present disclosure generally relates to systems and methods for detecting and/or monitoring respiratory events (e.g., apnea and hypopneas) experienced by a subject during sleep and/or for generating a sleep quality metric for an individual, using one or more implanted or external sensors, as well as methods of treating medical conditions related thereto, such as obstructive sleep apnea.

Abstract: An electrode lead includes an elongate lead body and a nerve cuff. The nerve cuff may include a cuff body, with a front layer and a rear layer, affixed to the distal end of the lead body and a plurality of electrically conductive members located between the front and rear layers. Each of the electrically conductive member defines a front side, a rear side and an outer perimeter and may include a plurality of holes that extend from the front side to the rear side and that are located around the outer perimeter. The cuff body front layer includes a plurality of windows that are respectively aligned with and located inwardly of the outer perimeters of the electrically conductive members, and a plurality of window frames that extend from the windows to the outer perimeters of the electrically conductive members. The cuff body also includes a plurality of anchors that respectively extend through the electrically conductive member holes and connect the window frames to the cuff body rear layer.

Abstract: The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

Abstract: A stimulation system configured to be implanted in a patient includes an implantable pulse generator (IPG) and an implantable lead system. The IPG includes a processor, a memory device, a power supply, and an inertial sensing unit configured to measure one or more physiological indicators of the patient. The implantable lead system includes at least one electrical lead coupled to the power supply and at least one electrode at a distal end of the electrical lead. The memory device includes instructions that cause the IPG to receive the physiological indicators within an initial range; increase the initial range to an enlarged range in response to the physiological indicators crossing a threshold maximum value or a threshold minimum value of the initial range; receive the physiological signals within the enlarged range, analyze the physiological indicators, and deliver stimulation to the patient through the electrode in response to the physiological indicators.

Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

Abstract: The disclosure provides systems and methods for treating obstructive sleep apnea using a sensor (e.g., an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope), wherein the sensor is configured to detect chest and/or abdominal movement by a subject (e.g., a human subject) during the inspiration and expiration stages of a respiratory cycle and to generate positional and/or velocity data based on the detected movement. Positional and/or velocity data generated by the sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

Abstract: A method for providing stimulation of living tissue may include generating electrical pulses onto multiple output channels to a plurality of electrodes each corresponding to one of the multiple output channels. The method may also include disconnecting the plurality of electrodes from recording amplifiers during a stimulation. Additionally, the method may include shorting, after each stimulation before recording is resumed, inputs of the recording amplifiers to ground to suppress ringing in the recording system.

Abstract: The present disclosure generally relates to systems and methods for monitoring and/or the sleep stage of an individual using one or more sensors, and methods of treating medical conditions related thereto (e.g., obstructive sleep apnea).

Abstract: The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

Abstract: The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

Abstract: The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

Abstract: A method for providing stimulation of living tissue may include generating electrical pulses onto multiple output channels to a plurality of electrodes each corresponding to one of the multiple output channels. The method may also include disconnecting the plurality of electrodes from recording amplifiers during a stimulation. Additionally, the method may include shorting, after each stimulation before recording is resumed, inputs of the recording amplifiers to ground to suppress ringing in the recording system.