Patents by Inventor Sahar Javanmard

Sahar Javanmard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inactivators of O6-alkylguanine-DNA alkyltransferase
    Patent number: 8188055
    Abstract: Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X1, X2, R1, and R2 are as described herein. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells and inactivating AGT in a tumor cell. The methods comprise, inter alia, administering a compound or pharmaceutically acceptable salt of formula (I).
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: May 29, 2012
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Penn State Research Foundation
    Inventors: Robert C. Moschel, Matthew Karl Moschel, legal representative, Anthony E. Pegg, Sahar Javanmard, Natalia Loktionova, Gary Pauly
  • INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
    Publication number: 20100204172
    Abstract: Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X1, X2, R1, and R2 are as described herein. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells and inactivating AGT in a tumor cell. The methods comprise, inter alia, administering a compound or pharmaceutically acceptable salt of formula (I).
    Type: Application
    Filed: March 12, 2008
    Publication date: August 12, 2010
    Applicants: Department of Health and Human Services, The Penn State Research Foundation
    Inventors: Robert C. Moschel, Anthony E. Pegg, Sahar Javanmard, Natalia Loktionova, Gary Pauly