Abstract: A minimal action, invasive blood constituent device can streamline the process for the self-monitoring of blood-related tests by holding and facilitating the use of some or all of the tools for obtaining and testing a blood sample. The device can include a slider, that when pumped, causes the device to spring-load a lancet and eject a testing strip. The device can include a trigger that, when pressed, activates the lancet by unloading the spring. A strip-lancet apparatus can combine the roles of two disposable products-a testing strip and a lancing needle-into an apparatus that can be configured for piercing the testing site as well as receiving the blood sample. A testing strip apparatus can facilitate the use and/or disposal of testing strips. A lancet apparatus can facilitate the use and/or disposal of lancets.

Abstract: A system which provides closed loop insulin administration is disclosed. The system includes redundant glucose sensors which may be interleaved in order to provide monitoring when one of the glucose sensors is in a settling period. The system may include a disease management unit which includes both a glucose sensor and an insulin pump. A closed loop disease management system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.

Abstract: Various spirometer-inhaler systems and devices are disclosed. The spirometer-inhaler system may estimate physiological parameters of a user based on the user's inhaled and/or exhaled breaths received by the spirometer-inhaler device. The spirometer-inhaler device may comprise one or more flow paths. A first flow path may direct medication from a medicine canister to an opening of the device. A second flow path may direct a user's exhaled breath from the opening of the device to one or more flow measurement devices.

Abstract: A system which provides closed loop insulin administration is disclosed. The system includes redundant glucose sensors which may be interleaved in order to provide monitoring when one of the glucose sensors is in a settling period. The system may include a disease management unit which includes both a glucose sensor and an insulin pump. A closed loop disease management system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.

Abstract: A minimal action, invasive blood constituent device can streamline the process for the self-monitoring of blood-related tests by holding and facilitating the use of some or all of the tools for obtaining and testing a blood sample. The device can include a slider, that when pumped, causes the device to spring-load a lancet and eject a testing strip. The device can include a trigger that, when pressed, activates the lancet by unloading the spring. A strip-lancet apparatus can combine the roles of two disposable products—a testing strip and a lancing needle—into an apparatus that can be configured for piercing the testing site as well as receiving the blood sample. A testing strip apparatus can facilitate the use and/or disposal of testing strips. A lancet apparatus can facilitate the use and/or disposal of lancets.

Abstract: A device may include a base configured to at least partially couple to skin of a patient. A device may include at least one module configured to removably couple to the base, the at least one module can include a first module. The first module can include a medication bladder, a medication pump configured to cause medication to flow from the medication bladder through a cannula configured to be inserted into a tissue site of the patient; and a cannula insertion device configured to insert the cannula into the tissue site of the patient by actuation of a spring released by a triggering component.

Abstract: Systems and methods disclosed herein relate to a disease management device which includes at least one or more medication bladders, configured to store fluid and a medication delivery pump, configured to deliver a fluid from one or more medication bladders to a patient. Each medication bladder has at least a rigid portion and a flexible portion, the flexible portion coupled to the rigid portion to create an at least partially sealed enclosure. The rigid portion includes structures, such as channels, configured to facilitate emptying the medication bladder through an output port. On application of pressure from the pump, the flexible portion is configured to generate a pressure against the structures rigid portion, which facilitates emptying of fluid from the medication bladder through the output port.

Abstract: Various spirometer-inhaler systems and devices are disclosed. The spirometer-inhaler system may estimate physiological parameters of a user based on the user's inhaled and/or exhaled breaths received by the spirometer-inhaler device. The spirometer-inhaler device may comprise one or more flow paths. A first flow path may direct medication from a medicine canister to an opening of the device. A second flow path may direct a user's exhaled breath from the opening of the device to one or more flow measurement devices.

Abstract: The present invention relates to a soluble dimeric fusion protein comprising a first and second polypeptides, wherein the first and second polypeptides each comprises a Dectin-1 receptor polypeptide fused to a human Fc domain via a dimerization linker. Methods of using the soluble dimeric fusion protein for immunizing a subject against a fungal infection, preventing or treating a fungal infection in a subject and detecting a fungal infection in a subject are also provided. In one embodiment, a chimeric molecule comprising the fusion protein and a payload is provided. In one embodiment, the payload is Amphotericin B.

Abstract: An apparatus for facilitating cultivation of plants. The apparatus comprises a top enclosure, a bottom enclosure, a vertical column, a cover, a tray, sensors, environmental actuators, a nutrition container, and a processing device. Further, the top enclosure houses a first component. Further, the bottom enclosure houses a second component. Further, the vertical column is interspersed between the top enclosure and the bottom enclosure is forming an interior space therebetween. Further, the cover is interspersed between the top enclosure and the bottom enclosure, encloses the interior space and allows light to enter from a surrounding of the apparatus into the interior space. Further, the tray holds a plant. Further, the sensors generate sensor data representing variables. Further, the environmental actuators control environmental variables. Further, the nutrition container contains a nutritional medium. Further, the processing device controls the environmental actuators based on the sensor data.

Abstract: A disease management system including a medication delivery pump configured to deliver a medication from a medication pouch to a patient. The medication delivery pump may include one or more plungers configured to interrupt a flow path of medication from a medication reservoir to a patient, one or more muscle wires, and one or more disc shaped springs. The one or more muscle wires and disc shaped springs may be configured to move the one or more plungers to interrupt and uninterrupt the flow path of medication towards a patient from a medication pouch.

Abstract: The invention relates to a method of increasing the number of ?2,3,-?2,6-disialylgalactose N-glycans on a glycoprotein by incubating an ?2,3-sialylated glycoprotein with an ?2,6-sialyltransferase and a sialic acid source. Also provided is a recombinant glycoprotein comprising at least one ?2,3,-?2,6-disialylgalactose N-glycan. In a particular embodiment, the recombinant glycoprotein is alpha-1 antitrypsin (AAT).

Abstract: The invention relates to serum-free cell culture medium, wherein the medium either contains maltose as the sole carbohydrate source, or contains maltose and at least one other saccharide as carbohydrate sources. In a preferred embodiment, the additional saccharide is a monosaccharide, preferably glucose, and the medium comprises DMEM-F12. In a preferred embodiment the cells to be cultured may be CHO or HEK293 cells. Also disclosed are methods of growing and/or culturing a cell using the cell culture medium as described herein, methods of increasing protein yield using the cell culture medium as described herein, and kits thereof.

Abstract: Various spirometer-inhaler systems and devices are disclosed. The spirometer-inhaler system may estimate physiological parameters of a user based on the user's inhaled and/or exhaled breaths received by the spirometer-inhaler device. The spirometer-inhaler device may comprise one or more flow paths. A first flow path may direct medication from a medicine canister to an opening of the device. A second flow path may direct a user's exhaled breath from the opening of the device to one or more flow measurement devices.

Abstract: The disease management system can determine a measurement of one or more physiological parameters and can determine a disease event based on the one or more measurements. Furthermore, the disease management system can determine a pose of an individual using a pose sensor. Based on an identification of a disease event and a determination that the pose of the individual corresponds to a first pose, the disease management system can cause at least one of an audible, visual, or vibratory alarm. Based on an identification of a disease event and a determination that the pose of the individual does not correspond to the first pose, the disease management system can cause administration of a medication to the individual.

Abstract: A system and method for providing search results is disclosed. One embodiment includes first presenting an image containing a product to a user and providing the user with a user interface for selecting the image, or a portion of the image associated with the product, from among several images. Search results are generated by searching for at least one characteristic based on one tag applied to the image or portion of the image in a database associated with a brand or designer identified in a second tag. In another embodiment, a user is provided with an upload interface to upload and tag an image so that the image is tagged for use in generating and providing search results to an independent user.

Abstract: A minimal action, invasive blood constituent device can streamline the process for the self-monitoring of blood-related tests by holding and facilitating the use of some or all of the tools for obtaining and testing a blood sample. The device can include a slider, that when pumped, causes the device to spring-load a lancet and eject a testing strip. The device can include a trigger that, when pressed, activates the lancet by unloading the spring. A strip-lancet apparatus can combine the roles of two disposable products—a testing strip and a lancing needle—into an apparatus that can be configured for piercing the testing site as well as receiving the blood sample. A testing strip apparatus can facilitate the use and/or disposal of testing strips. A lancet apparatus can facilitate the use and/or disposal of lancets.

Abstract: A system which provides closed loop insulin administration is disclosed. The system includes redundant glucose sensors which may be interleaved in order to provide monitoring when one of the glucose sensors is in a settling period. The system may include a disease management unit which includes both a glucose sensor and an insulin pump. A closed loop disease management system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.

Abstract: The invention relates to serum-free cell culture medium, wherein the medium either contains maltose as the sole carbohydrate source, or contains maltose and at least one other saccharide as carbohydrate sources. In a preferred embodiment, the additional saccharide is a monosaccharide, preferably glucose, and the medium comprises DMEM-F12. In a preferred embodiment the cells to be cultured may be CHO or HEK293 cells. Also disclosed are methods of growing and/or culturing a cell using the cell culture medium as described herein, methods of increasing protein yield using the cell culture medium as described herein, and kits thereof.

Abstract: A system for measuring presence and/or amount of a target antibody in a sample comprising a nanoparticle adapted to quench fluorescence emission, an Fc binding protein immobilized or absorbed on the nanoparticle, and a fluorescing antibody adapted for binding to the Fc binding protein and having a lower binding affinity to the Fc binding protein than the target antibody. According to further embodiments of the present invention, methods of measuring presence and/or amount of a target antibody in a sample are also provided. The methods comprise mixing the sample with the components of the system and measuring the change in fluorescent intensity as compared to the total fluorescent intensity before the mixing.