Patents by Inventor Said M. Sebti

Said M. Sebti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (Mono) ethylenediaminenitroplatinum (IV) complexes with ligands of oxides of nitrogen as possible anti-tumor agents
    Patent number: 5849790
    Abstract: The present invention discloses (mono)ethylenediaminenitroplatinum (IV) complexes of with ligands of oxides of nitrogen, and their synthesis, which, in vivo, may be reduced to produce "cisplatin" type platinum(II) antitumor complex and nitric oxide, which also reportedly has anti-tumor activity.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: December 15, 1998
    Assignee: The University of South Florida
    Inventors: Jay W. Palmer, Joseph A. Stanko, Said M. Sebti, Julia R. Burdge
  • Inhibitors of farnesyltransferase
    Patent number: 5834434
    Abstract: Peptidomimetics of the formula C.beta.X where C is cysteine, X is any naturally occuring amino acid, and .beta. is a hydrophobic spacer, most notably 2-phenyl-4-aminobenzoic acid. These compounds are effective inhibitors of p2lras farnesyltrasferase, block Ras-dependent oncogenic signalling and inhibit human tumor growth in vivo in animal models. Pro-drugs made by functionalizing terminal amino and carboxylic acid groups of peptides and peptidomimetics are also disclosed. Such functionalized derivatives demonstrate increased cell uptake. Other structural modifications are also disclosed.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: November 10, 1998
    Assignee: University of Pittsburgh
    Inventors: Said M. Sebti, Andrew Hamilton
  • Fluorescent-labelled bleomycin analogues
    Patent number: 5420228
    Abstract: A fluorescent-labelled bleomycin analog useful as a probe for measuring cellular uptake of bleomycin and bleomycin derivatives, including methods of making and using same. The analog may further be used as a therapeutic agent as well as a diagnostic tool.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: May 30, 1995
    Assignee: University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: John S. Lazo, Jehangir S. Mistry, Jitesh P. Jani, Said M. Sebti