Patents by Inventor Saima Mahmood Malhi

Saima Mahmood Malhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of c-FOS and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel anti-epileptic compound HHL-6
    Patent number: 9272998
    Abstract: The present invention evaluated the anti-epileptogenic effect of tryptamine derivative HHL-6 and its effects on the expression of BDNF and c-Fos. HHL-6 possesses potent anticonvulsant and anti-epileptic activity in PTZ-induced acute seizure and chemical kindling model of epilepsy. The results suggests that one of the possible mechanism of HHL-6 to inhibit epileptogenesis might be due to its controlling effect on the cellular and molecular expression of the factors that contribute in the development of epileptogenic plasticity in the CNS.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: March 1, 2016
    Inventors: Shabana Usman Simjee, Sabira Begum, Saima Mahmood Malhi, Huma Jawed, Nadeem Ashraf, Farina Hanif, Bina S. Siddiqui, Farhat Zubair
  • SYNTHESIS AND BIOLOGICAL STUDIES OF AN ISOMERIC MIXTURE OF (E/Z) ISOXYLITONES AND ITS ANALOGUES
    Publication number: 20150148417
    Abstract: The invention relates to an anti-epileptic isoxylitone, 2,2?-(3,5,5-Trimethyl-2-cylohexen-1-ylidene)acetic acid.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: Atta-ur- Rahman, M. Iqbal Choudhary, Farzana Shaheen, Shabana Usman Simjee, Noureen Kahn, Saima Mahmood Malhi, Syed Uzair Ali Shah, Muhammad Nadeem Ashraf
  • SYNTHESIS AND BIOLOGICAL STUDIES OF AN ISOMERIC MIXTURE OF (E/Z) ISOXYLITONES AND ITS ANALOGUES
    Publication number: 20140221682
    Abstract: The invention relates to an anti-epileptic isoxylitone, 2,2?-(3,5,5-Trimethyl-2-cyclohexen-1-ylidene) acetic acid.
    Type: Application
    Filed: February 4, 2013
    Publication date: August 7, 2014
    Inventors: Atta-ur Rahman, M. Iqbal Choudhary, Farzana Shaheen, Shabana Usman Simjee, Noureen Kahn, Saima Mahmood Malhi, Syed Uzair Ali Shah, Muhammad Nadeem Ashraf