Patents by Inventor Saiyong Zhu

Saiyong Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATING HEPATOCYTES
    Publication number: 20170073636
    Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Inventors: Saiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
  • Reprogramming of cells to a new fate
    Patent number: 9556417
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: January 31, 2017
    Assignee: The Scripps Research Institute
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9540615
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 10, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9534205
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: January 3, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20160369244
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 22, 2016
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • Generating hepatocytes
    Patent number: 9512406
    Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
    Type: Grant
    Filed: December 20, 2014
    Date of Patent: December 6, 2016
    Assignees: The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of California
    Inventors: Saiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
  • GENERATING DEFINITIVE ENDODERM AND PANCREATIC PROGENITOR CELLS
    Publication number: 20160272944
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of definitive endoderm cells, posterior foregut-like progenitor cells, pancreatic progenitor cells and/or pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes.
    Type: Application
    Filed: July 25, 2014
    Publication date: September 22, 2016
    Inventors: Sheng Ding, Ke Li, Saiyong Zhu
  • Reprogramming of Cells to a New Fate
    Publication number: 20160264938
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Application
    Filed: March 17, 2016
    Publication date: September 15, 2016
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Reprogramming Cells
    Publication number: 20160257938
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: March 14, 2016
    Publication date: September 8, 2016
    Inventors: Saiyong Zhu, Sheng Ding
  • Reprogramming of cells to a new fate
    Patent number: 9376664
    Abstract: Methods and compositions for transdifferentiation of an animal cell from (i) a first pluripotent cell fate to a second nonpluripotent cell fate or (ii) from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: June 28, 2016
    Assignee: The Scripps Research Institute
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Reprogramming cells
    Patent number: 9315779
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: April 19, 2016
    Assignee: The Scripps Research Institute
    Inventors: Saiyong Zhu, Sheng Ding
  • GENERATING HEPATOCYTES
    Publication number: 20150175962
    Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
    Type: Application
    Filed: December 20, 2014
    Publication date: June 25, 2015
    Applicants: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads, The Regents of the University of California
    Inventors: Saiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
  • REPROGRAMMING CELLS
    Publication number: 20130323833
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: May 16, 2013
    Publication date: December 5, 2013
    Inventors: Saiyong Zhu, Sheng Ding
  • REPROGRAMMING OF CELLS TO A NEW FATE
    Publication number: 20130280809
    Abstract: Methods and compositions for transdifferentiation of an animal cell from (i) a first pluripotent cell fate to a second nonpluripotent cell fate or (ii) from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Application
    Filed: June 14, 2011
    Publication date: October 24, 2013
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20130273536
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells
    Publication number: 20110110899
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: March 17, 2009
    Publication date: May 12, 2011
    Applicant: SCRIPPS RESEARCH INSTITUTE
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20100267141
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: April 2, 2010
    Publication date: October 21, 2010
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding