Patents by Inventor Sajinder Kaur Luthra
Sajinder Kaur Luthra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11135322Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: GrantFiled: January 22, 2013Date of Patent: October 5, 2021Assignees: GE Healthcare Limited, University of SouthamptonInventors: Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
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Patent number: 9169284Abstract: This invention relates to the miniaturization of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).Type: GrantFiled: April 15, 2014Date of Patent: October 27, 2015Assignee: Hammersmith Imanet LimitedInventors: Frank Brady, Sajinder Kaur Luthra, James Millar Gillies, Nicholas Toby Jeffrey
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Publication number: 20150126708Abstract: The present invention provides a method of radio fluorination of biological targeting molecules (BTMs) with the radioisotope 18F. Also provided are novel conjugates useful in the 18F-radio fluorination method, and the use of such conjugates and automated synthesizer apparatus including cassettes for carrying out the method.Type: ApplicationFiled: December 20, 2012Publication date: May 7, 2015Applicants: IMPERIAL INNOVATIONS LIMITED, GE HEALTHCARE LIMITEDInventors: Sajinder Kaur Luthra, Robin Fortt, Ramala Osman Awais, Eric Ofori Aboagye, Graham Smith
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Publication number: 20140377178Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: ApplicationFiled: January 22, 2013Publication date: December 25, 2014Applicants: UNIVERSITY OF SOUTHAMPTON, GE HEALTHCARE LIMITEDInventors: Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
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Publication number: 20140316130Abstract: This invention relates to the miniaturisation of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).Type: ApplicationFiled: April 15, 2014Publication date: October 23, 2014Applicant: HAMMERSMITH IMANET LIMITEDInventors: FRANK BRADY, SAJINDER KAUR LUTHRA, JAMES MILLAR GILLIES, NICHOLAS TOBY JEFFREY
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Publication number: 20130334443Abstract: Components and systems for a PET radiopharmacy include a transport shield for a radioisotope cartridge, a cassette for dispensing from a transport shield, a cassette synthesis platform for a cassette, and a synthesizer shield.Type: ApplicationFiled: December 22, 2011Publication date: December 19, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Colin Steel, Sajinder Kaur Luthra, Robin Fortt, Farah Shah
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Patent number: 8506932Abstract: The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.Type: GrantFiled: November 20, 2006Date of Patent: August 13, 2013Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Ian Wilson, Sajinder Kaur Luthra, Frank Brady, Bengt Langstrom, Farhad Karimi, Edward George Robins, Bo Shan
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Patent number: 8323616Abstract: The invention provides a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I) SOLID SUPPORT-LINKER-X-TRACER (I) wherein X is a group which promotes nucleophilic substitution at a specific site on the attached TRACER and the TRACER is of formula (A).Type: GrantFiled: December 19, 2003Date of Patent: December 4, 2012Assignees: GE Healthcare Limited, Hammersmith Imanet LimitedInventors: Frank Brady, Sajinder Kaur Luthra, Alexander Mark Gibson
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Publication number: 20120275973Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Applicants: HAMMERSMITH IMANET LIMITED, GE HEALTHCARE AS, GE HEALTHCARE LIMITEDInventors: SAJINDER KAUR LUTHRA, FRANK BRADY, NICHOLAS TOBY JEFFERY, ERIK ARSTAD, ALEXANDER MARK GIBSON, DUNCAN WYNN, ALAN CUTHBERTSON, MAGNE SOLBAKKEN
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Patent number: 8221720Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.Type: GrantFiled: May 11, 2005Date of Patent: July 17, 2012Assignees: Hammersmith Imanet Limited, GE Healthcare Limited, GE Healthcare ASInventors: Sajinder Kaur Luthra, Frank Brady, Nicholas Toby Jeffery, Erik Arstad, Alexander Mark Gibson, Duncan Wynn, Alan Cuthbertson, Magne Solbakken
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Patent number: 8124050Abstract: A method for coating the internal surfaces of a reaction vessel having a small internal diameter comprises the steps of (i) introducing into the reaction vessel a solution of one or more monomers in a suitable solvent; (ii) introducing a flow of an inert gas through the reaction vessel; and (iii) initiating polymerization of the monomer solution.Type: GrantFiled: December 23, 2004Date of Patent: February 28, 2012Assignee: Hammersmith Imanet LimitedInventors: Frank Brady, Nicholas Toby Jeffery, Sajinder Kaur Luthra, Erik Arstad
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Patent number: 7999139Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX??(I) wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo; with 18F? to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X??(II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F?, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.Type: GrantFiled: May 1, 2007Date of Patent: August 16, 2011Assignee: Hammersmith Imanet LimitedInventors: Frank Brady, Sajinder Kaur Luthra, Yongjun Zhao
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Publication number: 20090220420Abstract: The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.Type: ApplicationFiled: November 20, 2006Publication date: September 3, 2009Inventors: Erik Arstad, Ian Wilson, Sajinder Kaur Luthra, Frank Brady, Bengt Langstrom, Farhad Karimi, Edward George Robins, Bo Shan
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Patent number: 7504208Abstract: The invention relates to a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-I+-TRACER (I) Y? wherein the TRACER is of formula (A): or an amine protected derivative thereof, wherein Y? is an anion, preferably trifluoromethylsulphonate (triflate) anion; and R1 is either (i) a group CH—NP1AP2A in which P1A and P2A are each independently hydrogen or a protecting group, or (ii) a carbonyl group; with 18F? to produce the labelled tracer of formula (II) or an amine protected derivative thereof, wherein R1 is as defined for the compound of formula (I).Type: GrantFiled: December 19, 2003Date of Patent: March 17, 2009Assignee: Hammersmith Imanet LimitedInventors: Frank Brady, Sajinder Kaur Luthra, Edward George Robins
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Patent number: 7432397Abstract: The invention relates to compounds of formula: (I) or a salt or solvate thereof, wherein: R1 is —11CH2R5 or [18F]—C1-4 fluoroalkyl wherein R5 is hydrogen or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is halo; and R4 is halo, C1-4 alkylthio, or C1-4 alkyl; and their use for imaging central nervous system (CNS) receptors.Type: GrantFiled: July 16, 2003Date of Patent: October 7, 2008Assignee: Hammersmith Imanet Ltd.Inventors: Frank Brady, Sajinder Kaur Luthra
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Publication number: 20080213174Abstract: The invention relates to in vivo imaging agents, specifically radiolabelled insulin derivatives of formula (III); wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—, and is preferably —CO—NH—, —NH— or —O—; Y is H, alkyl or aryl substituents; R* is a radiolabel moiety suitable for detection by SPECT or PET; and methods for preparing the same as well as their use in in vivo imaging methods.Type: ApplicationFiled: September 13, 2005Publication date: September 4, 2008Inventors: Matthias Eberhard Glaser, Frank Brady, Sajinder Kaur Luthra, Alan Cuthbertson, Hege Karlsen
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Patent number: 7223891Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with 18F? to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F?, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.Type: GrantFiled: December 19, 2003Date of Patent: May 29, 2007Assignee: Hammersmith Imanet Ltd.Inventors: Frank Brady, Sajinder Kaur Luthra, Yongjun Zhao
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Patent number: 7115249Abstract: The invention relates to compounds of formula (I); wherein R1 and R2 independently selected from C1-6 alkyl; P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and their use in the preparation of 18F-labelled 6-L-fluorodopaType: GrantFiled: June 18, 2002Date of Patent: October 3, 2006Assignees: GE Healthcare Ltd., Hammersmith Imanet Ltd.Inventors: Sajinder Kaur Luthra, Frank Brady, Harry John Wadsworth
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Publication number: 20040236085Abstract: The present invention relates to novel solid-phase processes for the production of radiolabelled tracers, in particular for the production of 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers. The invention also comprises radiopharmaceutical kits using these novel processes.Type: ApplicationFiled: July 15, 2004Publication date: November 25, 2004Inventors: Sajinder Kaur Luthra, Frank Brady, Harry John Wadsworth, Alexander Mark Gibson, Matthias Eberhard Glaser
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Publication number: 20040186312Abstract: The invention relates to compounds of formula (I); wherein R1 and R2 independently selected from C1-6 alkyl; P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and their use in the preparation of 18F-labelled 6-L-fluorodopa.Type: ApplicationFiled: December 24, 2003Publication date: September 23, 2004Inventors: Sajinder Kaur Luthra, Frank Brady, Harry John Wadsworth