Abstract: Hydrophilic infusion tubes and infusion components are provided. A fluid pathway connects a first fluid port and a second fluid port, the fluid pathway formed of a base material suitable for fluid infusion and a hydrophilic fluid interfacing surface disposed on an inner surface of the fluid pathway. The hydrophilic fluid interfacing surface provides a water wetting contact angle that is less than a water wetting contact angle provided by the base material. Infusion sets are also provided.