Abstract: A reamer incudes a core and a plurality of outer-circumference cutting edges provided on an outer circumference of the core and made of a hard tool material. The core extends from a front end to a rear end. The core is provided with a plurality of flutes from the front end to the rear end. A center-of-gravity adjustment portion, which adjusts a distance from a center of rotation to a center of gravity, is provided at least partially from terminal ends of the plurality of flutes on a rear end side to the rear end of the core. The center-of-gravity adjustment portion causes the deviation of the center of gravity from the center of rotation to be smaller than when no center-of-gravity adjustment portion is provided.

Abstract: A reamer incudes a core and a plurality of outer-circumference cutting edges provided on an outer circumference of the core and made of a hard tool material. The core extends from a front end to a rear end. The core is provided with a plurality of flutes from the front end to the rear end. A center-of-gravity adjustment portion, which adjusts a distance from a center of rotation to a center of gravity, is provided at least partially from terminal ends of the plurality of flutes on a rear end side to the rear end of the core. The center-of-gravity adjustment portion causes the deviation of the center of gravity from the center of rotation to be smaller than when no center-of-gravity adjustment portion is provided.

Abstract: A reamer includes a core, a plurality of outer-circumference cutting edges provided on an outer circumference of the core and made of a hard tool material, and a margin provided on a rear side of each the plurality of outer-circumference cutting edges in a rotational direction. A distance from an axis of rotation to a position of a center of gravity of the reamer is greater than 0.01 mm and not greater than 0.5 mm.

Abstract: A reamer includes a core, a plurality of outer-circumference cutting edges provided on an outer circumference of the core and made of a hard tool material, and a margin provided on a rear side of each the plurality of outer-circumference cutting edges in a rotational direction. A distance from an axis of rotation to a position of a center of gravity of the reamer is greater than 0.01 mm and not greater than 0.5 mm.

Abstract: A reamer incudes a core and a plurality of outer-circumference cutting edges provided on an outer circumference of the core and made of a hard tool material. The core extends from a front end to a rear end. The core is provided with a plurality of flutes from the front end to the rear end. A center-of-gravity adjustment portion, which adjusts a distance from a center of rotation to a center of gravity, is provided at least partially from terminal ends of the plurality of flutes on a rear end side to the rear end of the core. The center-of-gravity adjustment portion causes the deviation of the center of gravity from the center of rotation to be smaller than when no center-of-gravity adjustment portion is provided.

Abstract: Provided is a perfuming method including applying a water-based product to a fabric or a human body and drying, the water-based product containing a perfume precursor composed of an ester of at least one perfume selected from maltol, ethyl maltol, vanillin, ethyl vanillin, and raspberry ketone and at least one aliphatic monocarboxylic acid or aliphatic dicarboxylic acid selected from lauric acid, myristic acid, palimitic acid, stearic acid, oleic acid, adipic acid, and sebacic acid; and subsequently bringing the perfume precursor into contact with moisture in the air to perform hydrolysis, thereby releasing a perfume.

Abstract: Provided is a perfuming method including applying a water-based product to a fabric or a human body and drying, the water-based product containing a perfume precursor composed of an ester of at least one perfume selected from maltol, ethyl maltol, vanillin, ethyl vanillin, and raspberry ketone and at least one aliphatic monocarboxylic acid or aliphatic dicarboxylic acid selected from lauric acid, myristic acid, palimitic acid, stearic acid, oleic acid, adipic acid, and sebacic acid; and subsequently bringing the perfume precursor into contact with moisture in the air to perform hydrolysis, thereby releasing a perfume.

Abstract: A valerolactone compound represented by the formula (I): wherein each of R1 and R2 is independently a hydrogen atom, a methyl group or an ethyl group wherein when R1 is a hydrogen atom, R2 is not a hydrogen atom; and wherein when R2 is a hydrogen atom, R1 is not a hydrogen atom, R3 is a hydrogen atom or a methyl group, and R4 is a propyl group, a 1-propenyl group or a phenyl group; a valerolactone compound represented by the formula (II): a process for preparing the same; and a perfume composition comprising the above-mentioned valerolactone compound.

Abstract: A valerolactone compound represented by the formula (I): wherein each of R1 and R2 is independently a hydrogen atom, a methyl group or an ethyl group wherein when R1 is a hydrogen atom, R2 is not a hydrogen atom; and wherein when R2 is a hydrogen atom, R1 is not a hydrogen atom, R3 is a hydrogen atom or a methyl group, and R4 is a propyl group, a 1-propenyl group or a phenyl group; a valerolactone compound represented by the formula (II): a process for preparing the same; and a perfume composition comprising the above-mentioned valerolactone compound.

Abstract: The present invention provides a citral acetal capable of sustaining a lemon aroma unique to citral and a perfume composition comprising the citral acetal, as well as an LDH inhibitor and a deodorant, cosmetics and a skin agent for external application, comprising the LDH inhibitor. The citral acetal of the present invention is represented by formula (1): wherein the wavy line represents a cis and/or trans form, and R represents a C1, to C9, linear or branched alkyl group.

Abstract: The present invention provides a citral acetal capable of sustaining a lemon aroma unique to citral and a perfume composition comprising the citral acetal, as well as an LDH inhibitor and a deodorant, cosmetics and a skin agent for external application, comprising the LDH inhibitor.

Abstract: A 3(2H)pyridazinone of the formula: ##STR1## wherein R.sub.1 is hydrogen, 2-propenyl, or straight chained or branched C.sub.1 -C.sub.4 alkyl; each of R.sub.2 and R.sub.3 which may be the same or different, is hydrogen, or straight chained or branched C.sub.1 -C.sub.3 alkyl; X is chlorine, or bromine; Y is hydrogen, halogen, nitro, amino, or --AR.sub.4 wherein A is oxygen, or sulfur, and R.sub.4 is hydroen, straight chained, branched or cyclic C.sub.1 -C.sub.8 alkyl, ##STR2## wherein R.sub.5 is hydrogen, or straight chained or branched C.sub.1 -C.sub.4 alkyl; and Ar is ##STR3## wherein each Z.sub.1 and Z.sub.2 which may be the same or different, is hydrogen, halogen, straight or branched C.sub.1 -C.sub.4 alkyl, or --OR.sub.6 wherein R.sub.6 is straight or branched C.sub.1 -C.sub.4 alkyl, and B is oxygen, sulfur, or --N.dbd.C-- (to form a quinoline or pyridine ring); or a pharamaceutically acceptable salt thereof.

Abstract: A 3(2H)pyridazinone of the formula: ##STR1## wherein R.sub.1 is hydrogen, 2-propenyl or straight chained or branched C.sub.1 -C.sub.4 alkyl; R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl; X is chlorine or bromine; Y is hydrogen, nitro, -NHR.sub.3 wherein R.sub.3 is hydrogen or straight chained or branched C.sub.1 -C.sub.4 alkyl, -AR.sub.4 wherein A is oxygen or sulfur and R.sub.4 is hydrogen, straight chained or branched C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl having one double bond, C.sub.3 -C.sub.6 alkynyl having one triple bond, phenyl or ##STR2## wherein R.sub.5 is hydrogen or C.sub.1 -C.sub.4 alkyl, or halogen; Z.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, -OR.sub.6 wherein R.sub.6 is hydrogen, straight chained or branched C.sub.1 -C.sub.8 alkyl or ##STR3## wherein n is an integer of from 1 to 4, -N(R.sub.7).sub.2 wherein R.sub.7 is C.sub.1 -C.sub.4 alkyl, or halogen; Z.sub.2 is C.sub.1 -C.sub.4 alkyl, -OR.sub.6 wherein R.sub.6 is as defined above, -N(R.sub.7).sub.2 wherein R.sub.

Abstract: A compound of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 which may be the same or different, is hydrogen or C.sub.1 -C.sub.4 alkyl; one of X.sup.1 and X.sup.2 is nitro, fluroine, chlorine, difluoromethyoxy or trifluoromethyl and the other is hydrogen, or both of X.sup.1 and X.sup.2 are chlorine; and Y is ##STR2## wherein A is C.sub. -C.sub.6 alkylene, each of Ar.sup.1 and Ar.sup.2 which may be the same or different, is phenyl which may be substituted by chlorine, fluorine or C.sub.1 -C.sub.3 alkoxy, and m is an integer of from 0 to 4, or Y is ##STR3## wherein A, Ar.sup.1 and Ar.sup.2 are as defined above when that both X.sup.1 and X.sup.2 are chlorine; or a pharmaceutically acceptable salt thereof.

Abstract: An optical isomer of a compound having the formula: ##STR1## wherein the two methyl groups at 4- and 6-positions of the dioxaphosphorinane ring assume trans configurations to each other, which has a levo-rotatory angle of optical rotation attributable to the asymmetric carbon atom at 4-position of the dihydropyridine ring, and a pharmaceutically acceptable salt thereof.

Abstract: A compound of the formula: ##STR1## wherein X is hydrogen or fluorine and n is 2 or 3; or its pharmaceutically acceptable salt.

Abstract: A compound of the formula: ##STR1## where X is hydrogen, nitro, trifluoromethyl, fluorine, chlorine, bromine or iodine; A is 1,3-propylene or 1,4-butylene which may be substituted by C.sub.1 -C.sub.3 alkyl, R is C.sub.1 -C.sub.4 alkyl, --Y--N(R.sup.1)(R.sup.2) or ##STR2## where each of R.sup.1, R.sup.2 and R.sup.3, which may be the same or different are hydrogen, C.sub.1 -C.sub.6 alkyl, or aralkyl, and Y is C.sub.2 -C.sub.6 alkylene, and Me is methyl, or its pharmaceutically acceptable salt. These compounds have utility as anti-hypertensive agents and coronary or peripheral vasodilators.