Abstract: The invention relates to compounds of formula (I): wherein A, RA1, RA2, RB, RC and RD are as defined herein, and associated aspects.

Abstract: Compounds of formula (I): (I) and related aspects.

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

Abstract: Compounds of formula (I): and related aspects.

Abstract: Compounds of formula (I): (I) and related aspects.

Abstract: Compounds of formula (I) wherein ring B is selected from the group consisting of Formula (B-a) and Formula (B-bc) as human cytidine triphosphate synthase 1 (CTPS 1) inhibitors for the treatment of proliferative diseases, such as e.g. cancer, such as e.g. leukemia and lymphoma, e.g. inflammatory skin diseases such as psoriasis, or e.g. multiple sclerosis. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. page 129 to page 302; examples; biological examples 1 and 2; tables 1-17). Specific examples are e.g.: N-(4-(5-Chloropyridin-3-yl)phenyl)-2-(2-(cyclopropane-sulfonamido) pyrimidin-4-yl)butanamide (Formula P1) or 1-(2-(Cyclopropanesulfonamido)pyrimidin-4-yl)-N-(4-(6-ethoxypyrazin-2-yl)phenyl)cyclopentanecarboxamide (Formula P2).

Abstract: The invention provides a compound of formula (I) and processes for the manufacture of such compounds, related intermediates, compositions comprising such compounds and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.

Abstract: The invention provides a compound of formula (I): formula (I) and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.

Abstract: Compounds of formula (I) as human cytidine triphosphate synthase 1 (CTPS1) inhibitors for the treatment of prolifera-tive diseases, such as e.g. cancer, such as e.g. leukemia and lymphoma, e.g. inflammatory skin diseases such as psoriasis, or e.g. multiple sclerosis. The present description discloses the synthesis and characterisa-tion of exemplary compounds as well as pharmacological data thereof (e.g. pages 64 to 80; examples; biological examples 1 and 2; e.g. compounds P140, P231 to P263; tables 1 to 10). Specific examples are e.g.: N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonami-N do) pyrimidin-4-yl)tetrahydro-2H-pyran-4-carboxamide (Formula (II)), or 1-(2-(cyclopropanesulfonamido)pyrimidin-4-yl)-N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)cyclohexane-1-carboxamide (Formula (III)).

Abstract: A plurality of water-related sensors may each include an environmental characteristic detection element, a power source, and a communication device to transmit data associated with water-related data at a site. A water impact data store may contain electronic records associated with prior water-related events at other sites along with water-related sensor location data for those sites, and a third-party information interface may receive third-party information. An enterprise analytics platform may automatically analyze the electronic records in the water impact data store to create a predictive analytics algorithm. The data associated with potential water-related data at the site and the third-party information may then be automatically analyzed, in substantially real-time, using the predictive analytics algorithm, and a result of the analysis may then be transmitted (e.g., to a party associated with the site and/or an on-site water shut-off valve).

Abstract: A plurality of water-related sensors may each include an environmental characteristic detection element, a power source, and a communication device to transmit data associated with water-related data at a site. A water impact data store may contain electronic records associated with prior water-related events at other sites along with water-related sensor location data for those sites, and a third-party information interface may receive third-party information. An enterprise analytics platform may automatically analyze the electronic records in the water impact data store to create a predictive analytics algorithm. The data associated with potential water-related data at the site and the third-party information may then be automatically analyzed, in substantially real-time, using the predictive analytics algorithm, and a result of the analysis may then be transmitted (e.g., to a party associated with the site and/or an on-site water shut-off valve).

Abstract: A computing device, method, and a non-transitory computer readable medium for articulation training for hearing impaired persons is disclosed. The computing device comprises a database including stored mel-frequency cepstral representations of audio recordings associated with text and/or images related to the audio recordings, a microphone configured to receive audible inputs and a display. The computing device is operatively connected to the database, the microphone and the display. The computing device includes circuitry and program instructions stored therein which when executed by one or more processors, cause the system to receive an audible input from the microphone, convert the audible input to a mel-frequency cepstral representation, search the database for a match of the mel-frequency cepstral representation to a stored mel-frequency cepstral representation and display the text and/or images related to the stored mel-frequency cepstral representation when the match is found.

Abstract: Compounds of formula (I), and related aspects.

Abstract: A sparse DOA estimation is based on a multi-level prime arrays (MLPAs) as a general structure for coprime arrays. The array uses multiple uniform subarrays “or levels” where the number of antenna elements of the subarrays are pairwise coprime integers. The subarrays overlap only at their first antenna element by adjusting the inter-element spacing. By selecting the number of antennas of the subarrays and controlling the inter-element spacing, various MLPAs of different features can be constructed. The configuration that realizes the maximum number of unique lags is recommended because the DOF is upper bounded by the number of lags.

Abstract: Compounds of formula (I): and related aspects.

Abstract: Compounds of formula (I): (I) and related aspects.

Abstract: A sparse DOA estimation is based on a multi-level prime arrays (MLPAs) as a general structure for coprime arrays. The array uses multiple uniform subarrays “or levels” where the number of antenna elements of the subarrays are pairwise coprime integers. The subarrays overlap only at their first antenna element by adjusting the inter-element spacing. By selecting the number of antennas of the subarrays and controlling the inter-element spacing, various MLPAs of different features can be constructed. The configuration that realizes the maximum number of unique lags is recommended because the DOF is upper bounded by the number of lags.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, Y1, Y2, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: A plurality of water-related sensors may each include an environmental characteristic detection element, a power source, and a communication device to transmit data associated with water-related data at a site. A water impact data store may contain electronic records associated with prior water-related events at other sites along with water-related sensor location data for those sites, and a third-party information interface may receive third-party information. An enterprise analytics platform may automatically analyze the electronic records in the water impact data store to create a predictive analytics algorithm. The data associated with potential water-related data at the site and the third-party information may then be automatically analyzed, in substantially real-time, using the predictive analytics algorithm, and a result of the analysis may then be transmitted (e.g., to a party associated with the site and/or an on-site water shut-off valve).

Abstract: A nanocomposite that includes a core containing silver nanoparticles, and a shell that includes polypyrrole and carbon nanotubes, wherein the polypyrrole covers at least a portion of the carbon nanotubes, and wherein the shell covers at least a portion of the core and a method of making the nanocomposite. Various combinations of the nanocomposite, the method of making the nanocomposite, and a method of disinfecting an aqueous solution with the nanocomposite, are also provided.