Abstract: A system for collecting a sample from a tissue includes a medical instrument having a sample collection region. One or more sensors is configured to detect one or more properties of a sample, and is configured to output at least one measured value representative of the one or more properties of the sample. An indicator is operatively connected to the one or more sensors and is configured to provide a notification to a user of the medical instrument based on the one or more properties of the sample detected by the at least one sensor. A method of guiding sample collection is also provided.

Abstract: A system for collecting a sample from a tissue includes a medical instrument having a sample collection region. One or more sensors is configured to detect one or more properties of a sample, and is configured to output at least one measured value representative of the one or more properties of the sample. An indicator is operatively connected to the one or more sensors and is configured to provide a notification to a user of the medical instrument based on the one or more properties of the sample detected by the at least one sensor. A method of guiding sample collection is also provided.

Abstract: The present invention provides devices for generating scalable patterned features on a substrate. In some embodiments, the device includes a means for forming and ejecting a succession of droplets, a charge tunnel, a quadrupole mechanism, a means for reducing the size of one or more of the droplets and one or more stream deflectors.

Abstract: The present invention provides methods of generating scalable patterned features on a substrate. The methods includes ejecting a succession of droplets; applying a force to the droplets in a manner such that the droplets travel along a designated path; altering the properties of one or more of the droplets in a manner so as to adjust the size of the droplets; and depositing the droplets on the substrate to generate patterned features on the substrate. The present invention also provides apparatuses for generating scalable patterned features on a substrate.

Abstract: The present invention provides methods of generating scalable micro to nano patterned features on a substrate. The methods include ejecting a succession of droplets; applying a force to the droplets in a manner such that the droplets travel along a designated path; altering the properties of droplets in a manner so as to adjust the size of the droplets from micrometer to nanometer; and depositing droplets on the substrate to generate patterned features on the substrate. Another aspect of the present invention provides an apparatus for generating scalable patterned features on a substrate. The apparatus includes a means for droplet forming and ejecting a succession of droplets; a means for altering the properties of droplets in a manner so as to adjust the size of the droplets from micrometer to nanometer; and one or more stream deflectors to control the direction of the droplets to generate patterned features on the substrate.