Abstract: A spray tip for dispensing fluids that react together includes a first lumen for a first fluid, a second lumen for a second fluid, and a dispensing cap located at distal ends of the respective first and second lumens and defining a distal end of the spray tip. The dispensing cap includes a distal end wall defining a closed end of the dispensing cap, a first spray opening formed in the distal end wall that is in fluid communication with the first lumen, a second spray opening formed in the distal end wall that is in fluid communication with the second lumen, and an external dividing wall that projects distally from the distal end wall of the dispensing cap and that extends between the first and second spray opening for forming a barrier between the first and second spray openings.

Abstract: Disclosed is a sealant, and techniques for making and using the sealant. The sealant may include three components that, when combined, produce the sealant: an electrophilic component, a nucleophilic component, and a doping component. The electrophilic component may include a first electrophilic material having a first functionality of a first reactive group. The nucleophilic component may include a first nucleophilic material having a second functionality of a second reactive group. The doping component may include a second electrophilic material having a third functionality of the first reactive group greater than the first functionality and/or a second nucleophilic material having a fourth functionality of the second reactive group greater than the second functionality. The doping component may be present in an amount sufficient to provide a 2-20% molar contribution of the first reactive group and/or the second reactive group in the sealant.

Abstract: The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.

Abstract: The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.

Abstract: A spray device includes side-by-side spray tips that are spaced from one another at a distal end of the spray device. A first spray tip has a first fluid pathway defining a first flow area. The first fluid pathway has a first swirl chamber having an outer perimeter and flutes having inner ends that direct a first fluid into the outer perimeter of the first swirl chamber for rotating the first fluid in a circular pattern. A second spray tip has a second fluid pathway that defines a second flow area that is larger than the first flow area. The second fluid pathway has a second swirl chamber having an outer perimeter and flutes having inner ends that direct a second fluid into the outer perimeter of the second swirl chamber for rotating the second fluid in a circular pattern.

Abstract: A spray device includes side-by-side spray tips that are spaced from one another at a distal end of the spray device. A first spray tip has a first fluid pathway defining a first flow area. The first fluid pathway has a first swirl chamber having an outer perimeter and flutes having inner ends that direct a first fluid into the outer perimeter of the first swirl chamber for rotating the first fluid in a circular pattern. A second spray tip has a second fluid pathway that defines a second flow area that is larger than the first flow area. The second fluid pathway has a second swirl chamber having an outer perimeter and flutes having inner ends that direct a second fluid into the outer perimeter of the second swirl chamber for rotating the second fluid in a circular pattern.

Abstract: Disclosed are devices for detection of bleeding during surgical procedures and uses thereof. Also disclosed are methods of localizing a bleeding site during surgical procedures, and methods for evaluating an intensity of bleeding during the surgical procedures. The detection of bleeding is based, inter alia, on the presence of thrombin activity in a bleeding site.

Abstract: A spray device includes a first spray tip having a first fluid pathway defining a first flow area, and a second spray tip includes a second fluid pathway that defines a second flow area that is larger than the first flow area of the first spray tip. The first and second spray tips are side-by-side and spaced from one another at a distal end of the spray device. When a first fluid having a volumetric flow rate is introduced into the first spray tip and a second fluid having the same volumetric flow rate is introduced into the second spray tip, the first fluid will flow through the first fluid pathway at a greater velocity than the second fluid will flow through the second fluid pathway.

Abstract: A resorbable scaffold for partial meniscus regeneration. The resorbable scaffold includes a polymer filament network and a matrix in the polymer filament network. The polymer filament network includes alternating layers of circumferentially-oriented filaments and radially-oriented filaments, and has a three-dimensional shape and geometry which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

Abstract: A spray device includes a first spray tip having a first fluid pathway defining a first flow area, and a second spray tip includes a second fluid pathway that defines a second flow area that is larger than the first flow area of the first spray tip. The first and second spray tips are side-by-side and spaced from one another at a distal end of the spray device. When a first fluid having a volumetric flow rate is introduced into the first spray tip and a second fluid having the same volumetric flow rate is introduced into the second spray tip, the first fluid will flow through the first fluid pathway at a greater velocity than the second fluid will flow through the second fluid pathway.

Abstract: A spray tip for dispensing fluids that react together includes a first lumen for a first fluid, a second lumen for a second fluid, and a dispensing cap located at distal ends of the respective first and second lumens and defining a distal end of the spray tip. The dispensing cap includes a distal end wall defining a closed end of the dispensing cap, a first spray opening formed in the distal end wall that is in fluid communication with the first lumen, a second spray opening formed in the distal end wall that is in fluid communication with the second lumen, and an external dividing wall that projects distally from the distal end wall of the dispensing cap and that extends between the first and second spray opening for forming a barrier between the first and second spray openings.

Abstract: A resorbable scaffold for partial meniscus regeneration. The resorbable scaffold includes a polymer filament network and a matrix in the polymer filament network. The polymer filament network includes alternating layers of circumferentially-oriented filaments and radially-oriented filaments, and has a three-dimensional shape and geometry which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.