Abstract: A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.

Abstract: Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.

Abstract: Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.

Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.

Abstract: Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.

Abstract: A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.

Abstract: A method and kit for stopping cerebrospinal fluid (CSF) leaks, comprising penetrating and passing through a dural tissue an applicator to access an interior dural space, injecting from the applicator a fibrinogen-containing solution into said dural space, applying a sealing member containing a fibrinogen polymerizing agent onto an exterior surface of the dural tissue, and forming a polymerized fibrinogen or polymerized fibrin clot by contacting the injected fibrinogen-containing solution and the fibrinogen polymerizing agent.

Abstract: The present invention provides a kit for preparing a composition for sealing a lung tract, comprising: (a) a first component comprising: (i) a fibrinogen solution, and (ii) prewet gelatin particles in an aqueous solution; and (b) a second component comprising: (i) a thrombin solution, and (ii) a dry gelatin powder; wherein the first and second components are stored separately and configured for mixing together to form a composition that is flowable and cross-linkable. The composition may be used to seal tissue tracts such as lung tissue tracts.

Abstract: A system for dispensing a biocompatible reactive formulation includes a first chamber containing a first fluid having a first reactive component, a second chamber containing a second fluid having a second reactive component, and a third chamber containing a third fluid. A spray tip assembly is configured for spraying a final mixture of the first, second and third fluids. The spray tip assembly has a spray tip housing, a mixing element disposed within the spray tip housing, a mixing chamber located between the mixing element and an inner surface of the spray tip housing.

Abstract: The present invention is directed to dry lyophilized foam plugs that are a polymeric reaction product of at least a pair of co-reactive polyethylene glycol having reactive moieties in which substantially all of reactive moieties have reacted prior to lyophilization or blend of biomaterial and a reactive polyethylene glycol or plasma derived biomaterial reaction product and wherein the plug has an overall pore void content of about 30-45%, and a microporous structure with an average pore generally between 20 and 95 ?m.

Abstract: A method for fabricating a resorbable scaffold for regeneration of meniscal tissue is disclosed. The method includes fabricating a polymer filament network using 3D printing in accordance with a digital model of the polymer filament network, such that the polymer filament network will include a first plurality of layers comprising the circumferentially-oriented filaments alternating with a second plurality of layers comprising the radially-oriented filaments, the polymer filament network having a three-dimensional shape and geometry between a first layer and a second layer which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.